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Systematic Review

n-3 PUFA Improve Emotion and Cognition during Menopause: A Systematic Review

1
IRCCS Fondazione Santa Lucia, Via Ardeatina 306, 00179 Rome, Italy
2
Department of Psychology, Sapienza University of Rome, Via dei Marsi 78, 00185 Rome, Italy
3
Department of Human Sciences, Guglielmo Marconi University, Via Plinio 44, 00193 Rome, Italy
*
Author to whom correspondence should be addressed.
PhD Program in Behavioral Neuroscience.
These authors contributed equally to this work.
Academic Editors: Aurora Bueno-Cavanillas and Naomi Cano-Ibáñez
Nutrients 2022, 14(9), 1982; https://doi.org/10.3390/nu14091982
Received: 13 April 2022 / Revised: 29 April 2022 / Accepted: 4 May 2022 / Published: 9 May 2022
(This article belongs to the Special Issue Effect of Lifestyle and Diet for Older Persons' Health)
Women show an increased risk of cognitive impairment and emotional disorders, such as anxiety and depression, when approaching menopause. Data on risk and protection factors have yielded robust evidence on the effects of lifestyle factors, such as diet, in preserving emotional and cognitive functioning. This review focused on the effects of omega-3 polyunsaturated fatty acids (n-3 PUFA) on anxiety, depression, and cognition during the menopausal transition. This systematic review considered all articles published until 31 December 2021, and the search was performed on two databases, PubMed and Scopus. The fields of interest were “menopause”, “n-3 PUFA” and “emotional and cognitive aspects”. Out of the 361 articles found on PubMed and 283 on Scopus, 17 met inclusion criteria. They encompassed 11 human and 6 animal studies. Most studies reported relieved depressive symptoms in relation to n-3 PUFA intake. While controversial results were found on anxiety and cognition in humans, n-3 PUFA consistently reduced anxiety symptoms and improved cognition in animal studies. Taken together, n-3 PUFA intake shows beneficial effects on emotional and cognitive behaviours during menopause transition. However, further investigations could increase knowledge about the effectiveness of n-3 PUFA on psychological well-being in this delicate period of feminine life. View Full-Text
Keywords: menopause; menopausal transition; ovariectomy; n-3 PUFA; anxiety; depression; cognition menopause; menopausal transition; ovariectomy; n-3 PUFA; anxiety; depression; cognition
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MDPI and ACS Style

Decandia, D.; Landolfo, E.; Sacchetti, S.; Gelfo, F.; Petrosini, L.; Cutuli, D. n-3 PUFA Improve Emotion and Cognition during Menopause: A Systematic Review. Nutrients 2022, 14, 1982. https://doi.org/10.3390/nu14091982

AMA Style

Decandia D, Landolfo E, Sacchetti S, Gelfo F, Petrosini L, Cutuli D. n-3 PUFA Improve Emotion and Cognition during Menopause: A Systematic Review. Nutrients. 2022; 14(9):1982. https://doi.org/10.3390/nu14091982

Chicago/Turabian Style

Decandia, Davide, Eugenia Landolfo, Stefano Sacchetti, Francesca Gelfo, Laura Petrosini, and Debora Cutuli. 2022. "n-3 PUFA Improve Emotion and Cognition during Menopause: A Systematic Review" Nutrients 14, no. 9: 1982. https://doi.org/10.3390/nu14091982

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