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Nutrients
Volume 14
Issue 9
10.3390/nu14091937
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Article

Effects of Moringa oleifera Lam. Supplementation on Inflammatory and Cardiometabolic Markers in Subjects with Prediabetes

by
Ligia E. Díaz-Prieto
1,
Sonia Gómez-Martínez
1,
Iván Vicente-Castro
1,
Carlos Heredia
2,
Elena A. González-Romero
2,
María del Carmen Martín-Ridaura
3,
Mercedes Ceinos
3,
María J. Picón
4,
Ascensión Marcos
1 and
Esther Nova
1,*
1
Immunonutrition Research Group, Department of Metabolism and Nutrition, Institute of Food Science and Technology and Nutrition (ICTAN)—CSIC, 28040 Madrid, Spain
2
Cea Bermúdez Primary Health Care Centre, Madrid Health Service, 28003 Madrid, Spain
3
Madrid-Health, Madrid City Hall, 28007 Madrid, Spain
4
Virgen de la Victoria University Hospital, 29010 Málaga, Spain
*
Author to whom correspondence should be addressed.
Nutrients 2022, 14(9), 1937; https://doi.org/10.3390/nu14091937
Submission received: 8 April 2022 / Revised: 1 May 2022 / Accepted: 2 May 2022 / Published: 5 May 2022
(This article belongs to the Special Issue Obesity and Inflammation: The Role of Nutrition and Diet)
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Abstract

Different parts of the Moringa oleifera Lam. (MO) tree are consumed as food or food supplements for their nutritional and medicinal value; however, very few human studies have been published on the topic. The current work was aimed to provide ancillary analysis to the antidiabetic effects previously reported in a double-blind, randomized, placebo-controlled, parallel group intervention conducted in patients with prediabetes. Thus, the effect of MO leaves on blood and fecal inflammatory markers, serum lipid profile, plasma antioxidant capacity and blood pressure was studied in participants who consumed 6 × 400 mg capsule/day of MO dry leaf powder (MO, n = 31) or placebo (PLC, n = 34) over 12 weeks. Differences between groups were assessed using each biomarker’s change score with, adjustment for fat status and the baseline value. In addition, a decision tree analysis was performed to find individual characteristics influencing the glycemic response to MO supplementation. No differences in the biomarker’s change scores were found between the groups; however, the decision tree analysis revealed that plasma TNF-α was a significant predictor of the subject’s HbA1c response (improvement YES/NO; 77% correct classification) in the MO group. In conclusion, TNF-α seems to be a key factor to identify potential respondents to MO leaf powder.
Keywords: Moringa oleifera Lam.; food supplement; prediabetes; glycemic control; inflammatory markers; serum lipid profile; blood pressure; total antioxidant capacity; fecal calprotectin Moringa oleifera Lam.; food supplement; prediabetes; glycemic control; inflammatory markers; serum lipid profile; blood pressure; total antioxidant capacity; fecal calprotectin

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MDPI and ACS Style

Díaz-Prieto, L.E.; Gómez-Martínez, S.; Vicente-Castro, I.; Heredia, C.; González-Romero, E.A.; Martín-Ridaura, M.d.C.; Ceinos, M.; Picón, M.J.; Marcos, A.; Nova, E. Effects of Moringa oleifera Lam. Supplementation on Inflammatory and Cardiometabolic Markers in Subjects with Prediabetes. Nutrients 2022, 14, 1937. https://doi.org/10.3390/nu14091937

AMA Style

Díaz-Prieto LE, Gómez-Martínez S, Vicente-Castro I, Heredia C, González-Romero EA, Martín-Ridaura MdC, Ceinos M, Picón MJ, Marcos A, Nova E. Effects of Moringa oleifera Lam. Supplementation on Inflammatory and Cardiometabolic Markers in Subjects with Prediabetes. Nutrients. 2022; 14(9):1937. https://doi.org/10.3390/nu14091937

Chicago/Turabian Style

Díaz-Prieto, Ligia E., Sonia Gómez-Martínez, Iván Vicente-Castro, Carlos Heredia, Elena A. González-Romero, María del Carmen Martín-Ridaura, Mercedes Ceinos, María J. Picón, Ascensión Marcos, and Esther Nova. 2022. "Effects of Moringa oleifera Lam. Supplementation on Inflammatory and Cardiometabolic Markers in Subjects with Prediabetes" Nutrients 14, no. 9: 1937. https://doi.org/10.3390/nu14091937

APA Style

Díaz-Prieto, L. E., Gómez-Martínez, S., Vicente-Castro, I., Heredia, C., González-Romero, E. A., Martín-Ridaura, M. d. C., Ceinos, M., Picón, M. J., Marcos, A., & Nova, E. (2022). Effects of Moringa oleifera Lam. Supplementation on Inflammatory and Cardiometabolic Markers in Subjects with Prediabetes. Nutrients, 14(9), 1937. https://doi.org/10.3390/nu14091937

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