What about TSH and Anti-Thyroid Antibodies in Patients with Autoimmune Thyroiditis and Celiac Disease Using a Gluten-Free Diet? A Systematic Review
Abstract
:1. Introduction
2. Methods
2.1. Conduction of Review
2.2. Search Strategy
2.3. Data Extraction
2.4. Study Quality Assessment
3. Results
3.1. Articles Retrieved
3.2. Qualitative Analysis (Systematic Review)
3.3. Quality Assessment
4. Discussion
Supplementary Materials
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
References
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First Author, Year [Ref] | Country | Design | Population | Case (n) | Control (n) |
---|---|---|---|---|---|
Metso, 2012 [14] | Finland | Prospective controlled study | Adult | 27 | 27 |
Krysiak, 2019 [15] | Poland | Prospective non-randomized study | Adult | 16 | 18 |
Asamoah, 2021 [16] | USA | Case report | Adult | 1 | 0 |
Mainardi, 2002 [17] | Italy | Prospective study | Adult | 2 | 0 |
Stramazzo, 2021 [18] | Italy | Letter to editor | Adult | 1 | 0 |
Valentino, 1999 [19] | Italy | Prospective study | Adult | 3 | 0 |
First Author [Ref] | Year | TSH Gluten-Free (mIU/L, Mean (SD)) | TSH Normal Diet (mIU/L, Mean (SD)) | fT3 Gluten-Free (pmol/L, Mean (SD)) | fT3 Normal Diet (pmol/L, Mean (SD)) | fT4 Gluten-Free (pmol/L, Mean (SD)) | fT4 Normal Diet (pmol/L, Mean (SD)) | Tg-Ab Gluten-Free (U/mL; Mean (SD)) | Tg-Ab Normal Diet (U/mL; Mean (SD)) | TPO-Ab Gluten-Free (U/mL; Mean (SD)) | TPO-Ab Normal Diet (U/mL; Mean (SD)) | 25-Hydroxyvitamin D Gluten-Free (ng/mL, Mean (SD)) | 25-Hydroxyvitamin D Normal Diet (ng/mL, Mean (SD)) |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Krysiak [15] | 2019 | Baseline 2.7 (1.0), after 6 months 2.4 (0.8), change -0.3 (0.2) | Baseline 2.9 (0.8), after 6 months 2.6 (0.9), change -0.3 (0.2) | Baseline 3.2 (0.6), after 6 months 3.6 (0.7), change 0.4 (0.3) | Baseline 3.1 (0.6), after 6 months 3.2 (0.7), change 0.1 (0.3) | Baseline 14.9 (2.3), after 6 months 16.1 (2.4), change 1.2 (1.4) | Baseline 15.3 (2.7), after 6 months 15.0 (2.3), change 0.3 (0.6) | Baseline 832 (311), after 6 months 629 (240), change -203 (120) | Baseline 792 (274), after 6 months 845 (324), change 53 (58) | Baseline 925 (265), after 6 months 705 (206), change -200 (105) | Baseline 891 (242), after 6 months 920 (280), change 29 (25) | Baseline 20 (6), after 6 months 25 (6), change 5 (3) | Baseline 21 (5), after 6 months 20 (5), change -1 (2) |
Metso [14] | 2012 | Median baseline 1.7, follow-up 12 months 1.7 | Median baseline 1.5, follow-up 12 months 1.7 | / | / | Median baseline 12.9 mU/L, follow-up 12 months 12.1 mU/L | Median baseline 12.1 mU/L, follow-up 12 months 12.7 mU/L | / | / | / | / | / | / |
Asamoah [16] | 2021 | Baseline 3.57, after 3 months 0.77, after 12 months 0.45 | / | / | / | Baseline 11.97, after 3 months 13.13, after 12 months 14.80 | / | / | / | / | / | / | / |
Mainardi [17] | 2002 | Baseline 13.5, after 10 months 7.65, after 18 months 0.65 | / | Baseline 2.7 pg/mL, after 10 months 2.5 | / | Baseline 0.85 ng/dL, after 10 months 0.86, after 18 months 1.18 | / | Baseline 222, after 10 months 888, after 18 months 305 | / | Baseline 265, after 10 months 716, after 18 months 289 | / | / | / |
Mainardi [17] | 2002 | Baseline 1.78, after 8 months 0.01 | / | After 8 months 3.6 pg/ml | / | Baseline 0.73 ng/dL, after 8 months 1.4 | / | Baseline 134, after 8 months 255 | / | Baseline 474, after 8 months 586 | / | / | / |
Stramazzo [18] | 2021 | Baseline 3.5, after 3 months 3.98, after 6 months 3.45 | / | / | / | Baseline 0.8 ng/dL, after 3 months 1, after 6 months 1.2 | / | Baseline 756, after 3 months 1533 | / | Baseline 549, after 3 months 651 | / | / | / |
Valentino [19] | 1999 | Baseline 9.8, after 6 months 1.5 | / | / | / | Baseline 7.5 pg/mL, after 6 months 12 | / | Baseline 212, after 6 months 206 | / | Baseline 2580, after 6 months 1976 | / | / | / |
Valentino [19] | 1999 | Baseline 9.1, after 6 months 1.3 | / | / | / | Baseline 8.2 pg/mL, after 6 months 10.9 | / | Baseline 450, after 6 months 380 | / | Baseline 1230, after 6 months 1115 | / | / | / |
Valentino [19] | 1999 | Baseline 7.9, after 6 months 1.1 | / | / | / | Baseline 7.3 pg/mL, after 6 months 11.8 | / | Baseline 312, after 6 months 210 | / | Baseline 1580, after 6 months 1395 | / | / | / |
Risk of Bias | Feasibility | ||||||
---|---|---|---|---|---|---|---|
First Author | Patient’s Selection | Index Test | Reference Standard | Flow and Timing | Patient’s Selection | Index Test | Reference Standard |
Krysiak | Low | Low | Low | Low | Low | Low | Low |
Metso | Low | Unclear | Low | Low | Low | Low | Low |
Mainardi | Low | Unclear | Unclear | Low | Low | Unclear | Low |
Valentino | High | Unclear | Unclear | Low | Low | Unclear | Low |
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Malandrini, S.; Trimboli, P.; Guzzaloni, G.; Virili, C.; Lucchini, B. What about TSH and Anti-Thyroid Antibodies in Patients with Autoimmune Thyroiditis and Celiac Disease Using a Gluten-Free Diet? A Systematic Review. Nutrients 2022, 14, 1681. https://doi.org/10.3390/nu14081681
Malandrini S, Trimboli P, Guzzaloni G, Virili C, Lucchini B. What about TSH and Anti-Thyroid Antibodies in Patients with Autoimmune Thyroiditis and Celiac Disease Using a Gluten-Free Diet? A Systematic Review. Nutrients. 2022; 14(8):1681. https://doi.org/10.3390/nu14081681
Chicago/Turabian StyleMalandrini, Sabrina, Pierpaolo Trimboli, Gabriele Guzzaloni, Camilla Virili, and Barbara Lucchini. 2022. "What about TSH and Anti-Thyroid Antibodies in Patients with Autoimmune Thyroiditis and Celiac Disease Using a Gluten-Free Diet? A Systematic Review" Nutrients 14, no. 8: 1681. https://doi.org/10.3390/nu14081681
APA StyleMalandrini, S., Trimboli, P., Guzzaloni, G., Virili, C., & Lucchini, B. (2022). What about TSH and Anti-Thyroid Antibodies in Patients with Autoimmune Thyroiditis and Celiac Disease Using a Gluten-Free Diet? A Systematic Review. Nutrients, 14(8), 1681. https://doi.org/10.3390/nu14081681