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Article

Dietary-Derived Essential Nutrients and Amyotrophic Lateral Sclerosis: A Two-Sample Mendelian Randomization Study

by 1,2,3,†, 1,2,3,†, 1,2,3, 1,2,3, 1,2,3, 4, 4 and 1,2,3,*
1
Department of Neurology, Peking University Third Hospital, Beijing 100191, China
2
Beijing Key Laboratory of Biomarker and Translational Research in Neurodegenerative Diseases, Beijing 100191, China
3
Key Laboratory for Neuroscience, National Health Commission/Ministry of Education, Peking University, Beijing 100191, China
4
Department of Epidemiology and Biostatistics, School of Public Health, Peking University, Beijing 100871, China
*
Author to whom correspondence should be addressed.
These authors contributed equally to this work.
Academic Editor: Susanna C. Larsson
Nutrients 2022, 14(5), 920; https://doi.org/10.3390/nu14050920
Received: 30 January 2022 / Accepted: 18 February 2022 / Published: 22 February 2022
Previous studies have suggested a close but inconsistent relationship between essential nutrients and the risk of amyotrophic lateral sclerosis (ALS), and whether this association is causal remains unknown. We aimed to investigate the potential causal relation between essential nutrients (essential amino acids, essential fatty acids, essential minerals, and essential vitamins) and the risk of ALS using Mendelian randomization (MR) analysis. Large-scale European-based genome-wide association studies’ (GWASs) summary data related to ALS (assembling 27,205 ALS patients and 110,881 controls) and essential nutrient concentrations were separately obtained. MR analysis was performed using the inverse variance–weighted (IVW) method, and sensitivity analysis was conducted by the weighted median method, simple median method, MR–Egger method and MR–PRESSO method. We found a causal association between genetically predicted linoleic acid (LA) and the risk of ALS (OR: 1.066; 95% CI: 1.011–1.125; p = 0.019). An inverse association with ALS risk was noted for vitamin D (OR: 0.899; 95% CI: 0.819–0.987; p = 0.025) and for vitamin E (OR: 0.461; 95% CI: 0.340–0.626; p = 6.25 × 10−7). The sensitivity analyses illustrated similar trends. No causal effect was observed between essential amino acids and minerals on ALS. Our study profiled the effects of diet-derived circulating nutrients on the risk of ALS and demonstrated that vitamin D and vitamin E are protective against the risk of ALS, and LA is a suggested risk factor for ALS. View Full-Text
Keywords: amyotrophic lateral sclerosis; nutrition; Mendelian randomization; genes; risk factor amyotrophic lateral sclerosis; nutrition; Mendelian randomization; genes; risk factor
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MDPI and ACS Style

Xia, K.; Wang, Y.; Zhang, L.; Tang, L.; Zhang, G.; Huang, T.; Huang, N.; Fan, D. Dietary-Derived Essential Nutrients and Amyotrophic Lateral Sclerosis: A Two-Sample Mendelian Randomization Study. Nutrients 2022, 14, 920. https://doi.org/10.3390/nu14050920

AMA Style

Xia K, Wang Y, Zhang L, Tang L, Zhang G, Huang T, Huang N, Fan D. Dietary-Derived Essential Nutrients and Amyotrophic Lateral Sclerosis: A Two-Sample Mendelian Randomization Study. Nutrients. 2022; 14(5):920. https://doi.org/10.3390/nu14050920

Chicago/Turabian Style

Xia, Kailin, Yajun Wang, Linjing Zhang, Lu Tang, Gan Zhang, Tao Huang, Ninghao Huang, and Dongsheng Fan. 2022. "Dietary-Derived Essential Nutrients and Amyotrophic Lateral Sclerosis: A Two-Sample Mendelian Randomization Study" Nutrients 14, no. 5: 920. https://doi.org/10.3390/nu14050920

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