Long-Term Consumption of a Sugar-Sweetened Soft Drink in Combination with a Western-Type Diet Is Associated with Morphological and Molecular Changes of Taste Markers Independent of Body Weight Development in Mice

Lieder, Barbara; Čonka, Jozef; Reiner, Agnes T.; Zabel, Victoria; Ameur, Dominik; Somoza, Mark M.; Šebeková, Katarína; Celec, Peter; Somoza, Veronika

doi:10.3390/nu14030594

Open AccessArticle

Long-Term Consumption of a Sugar-Sweetened Soft Drink in Combination with a Western-Type Diet Is Associated with Morphological and Molecular Changes of Taste Markers Independent of Body Weight Development in Mice

by

Barbara Lieder

^1,*,†

,

Jozef Čonka

^2,†,

Agnes T. Reiner

¹

,

Victoria Zabel

¹,

Dominik Ameur

³

,

Mark M. Somoza

^3,4,5

,

Katarína Šebeková

²

,

Peter Celec

²

and

Veronika Somoza

^1,4,6

¹

Department of Physiological Chemistry, Faculty of Chemistry, University of Vienna, 1090 Vienna, Austria

²

Institute of Molecular Biomedicine, Faculty of Medicine, Comenius University, 81101 Bratislava, Slovakia

³

Department of Inorganic Chemistry, Faculty of Chemistry, University of Vienna, 1090 Vienna, Austria

⁴

Leibniz Institute for Food Systems Biology at the Technical University of Munich, 85345 Freising, Germany

⁵

Food Chemistry and Molecular Sensory Science, Technical University of Munich, 85345 Freising, Germany

⁶

Nutritional Systems Biology, School of Life Sciences, Technical University of Munich, 85345 Freising, Germany

^*

Author to whom correspondence should be addressed.

^†

These authors contributed equally to this work.

Nutrients 2022, 14(3), 594; https://doi.org/10.3390/nu14030594

Submission received: 31 December 2021 / Revised: 20 January 2022 / Accepted: 27 January 2022 / Published: 29 January 2022

(This article belongs to the Section Carbohydrates)

Download

Browse Figures

Versions Notes

Abstract

We investigated whether the long-term intake of a typical sugar-sweetened soft drink (sugar-sweetened beverage, SSB) alters markers for taste function when combined with a standard diet (chow) or a model chow mimicking a Western diet (WD). Adult male CD1 mice had ad libitum access to tap water or SSB in combination with either the chow or the WD for 24 weeks. Energy intake from fluid and food was monitored three times a week. Cardiometabolic markers (body weight and composition, waist circumference, glucose and lipid profile, and blood pressure) were analyzed at the end of the intervention, as was the number and size of the fungiform papillae as well as mRNA levels of genes associated with the different cell types of taste buds and taste receptors in the circumvallate papillae using a cDNA microarray and qPCR. Although the overall energy intake was higher in the WD groups, there was no difference in body weight or other cardiometabolic markers between the SSB and water groups. The chemosensory surface from the fungiform papillae was reduced by 36 ± 19% (p < 0.05) in the WD group after SSB compared to water intake. In conclusion, the consumption of the SSB reduced the chemosensory surface of the fungiform papillae of CD1 mice when applied in combination with a WD independent of body weight. The data suggest synergistic effects of a high sugar-high fat diet on taste dysfunction, which could further influence food intake and promote a vicious cycle of overeating and taste dysfunction.

Keywords: taste dysfunction; diet; mice; sugar-sweetened beverage; Western diet

Graphical Abstract

Share and Cite

MDPI and ACS Style

Lieder, B.; Čonka, J.; Reiner, A.T.; Zabel, V.; Ameur, D.; Somoza, M.M.; Šebeková, K.; Celec, P.; Somoza, V. Long-Term Consumption of a Sugar-Sweetened Soft Drink in Combination with a Western-Type Diet Is Associated with Morphological and Molecular Changes of Taste Markers Independent of Body Weight Development in Mice. Nutrients 2022, 14, 594. https://doi.org/10.3390/nu14030594

AMA Style

Lieder B, Čonka J, Reiner AT, Zabel V, Ameur D, Somoza MM, Šebeková K, Celec P, Somoza V. Long-Term Consumption of a Sugar-Sweetened Soft Drink in Combination with a Western-Type Diet Is Associated with Morphological and Molecular Changes of Taste Markers Independent of Body Weight Development in Mice. Nutrients. 2022; 14(3):594. https://doi.org/10.3390/nu14030594

Chicago/Turabian Style

Lieder, Barbara, Jozef Čonka, Agnes T. Reiner, Victoria Zabel, Dominik Ameur, Mark M. Somoza, Katarína Šebeková, Peter Celec, and Veronika Somoza. 2022. "Long-Term Consumption of a Sugar-Sweetened Soft Drink in Combination with a Western-Type Diet Is Associated with Morphological and Molecular Changes of Taste Markers Independent of Body Weight Development in Mice" Nutrients 14, no. 3: 594. https://doi.org/10.3390/nu14030594

APA Style

Lieder, B., Čonka, J., Reiner, A. T., Zabel, V., Ameur, D., Somoza, M. M., Šebeková, K., Celec, P., & Somoza, V. (2022). Long-Term Consumption of a Sugar-Sweetened Soft Drink in Combination with a Western-Type Diet Is Associated with Morphological and Molecular Changes of Taste Markers Independent of Body Weight Development in Mice. Nutrients, 14(3), 594. https://doi.org/10.3390/nu14030594

Note that from the first issue of 2016, this journal uses article numbers instead of page numbers. See further details here.

Article Menu

Long-Term Consumption of a Sugar-Sweetened Soft Drink in Combination with a Western-Type Diet Is Associated with Morphological and Molecular Changes of Taste Markers Independent of Body Weight Development in Mice

Abstract

Share and Cite

Article Metrics

Article Access Statistics

Further Information

Guidelines

MDPI Initiatives

Follow MDPI