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Article

Trait Energy and Fatigue May Be Connected to Gut Bacteria among Young Physically Active Adults: An Exploratory Study

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Department of Physical Therapy, Clarkson University, Potsdam, NY 13699, USA
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Department of Biology, Clarkson University, Potsdam, NY 13699, USA
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Sports and Health Sciences, School of Health Sciences, American Public University System, Charles Town, WV 25414, USA
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Department of Chemistry, University of Tennessee, Knoxville, TN 37996, USA
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Biological and Small Molecule Mass Spectrometry Core, University of Tennessee, Knoxville, TN 37996, USA
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Department of Microbiology, Immunology and Parasitology, Louisiana State University Health Sciences Center, New Orleans, LA 70112, USA
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Molecular Research LP, 503 Clovis Rd, Shallowater, TX 79363, USA
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Department of Environmental and Occupational Health, School of Public Health, Texas A&M University, College Station, TX 37916, USA
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Center for Population Health and Aging, Texas A&M University, College Station, TX 77807, USA
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Department of Physiology, Louisiana State University Health Sciences Center, New Orleans, LA 70112, USA
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Authors to whom correspondence should be addressed.
Academic Editors: Ruggiero Francavilla and Franck Gael Carbonero
Nutrients 2022, 14(3), 466; https://doi.org/10.3390/nu14030466
Received: 10 December 2021 / Revised: 15 January 2022 / Accepted: 18 January 2022 / Published: 21 January 2022
(This article belongs to the Special Issue Gut Microbiome: Profound Implications for Diet and Health)
Recent scientific evidence suggests that traits energy and fatigue are two unique unipolar moods with distinct mental and physical components. This exploratory study investigated the correlation between mental energy (ME), mental fatigue (MF), physical energy (PE), physical fatigue (PF), and the gut microbiome. The four moods were assessed by survey, and the gut microbiome and metabolome were determined from 16 S rRNA analysis and untargeted metabolomics analysis, respectively. Twenty subjects who were 31 ± 5 y, physically active, and not obese (26.4 ± 4.4 kg/m2) participated. Bacteroidetes (45%), the most prominent phyla, was only negatively correlated with PF. The second most predominant and butyrate-producing phyla, Firmicutes (43%), had members that correlated with each trait. However, the bacteria Anaerostipes was positively correlated with ME (0.048, p = 0.032) and negatively with MF (−0.532, p = 0.016) and PF (−0.448, p = 0.048), respectively. Diet influences the gut microbiota composition, and only one food group, processed meat, was correlated with the four moods—positively with MF (0.538, p = 0.014) and PF (0.513, p = 0.021) and negatively with ME (−0.790, p < 0.001) and PE (−0.478, p = 0.021). Only the Firmicutes genus Holdemania was correlated with processed meat (r = 0.488, p = 0.029). Distinct metabolic profiles were observed, yet these profiles were not significantly correlated with the traits. Study findings suggest that energy and fatigue are unique traits that could be defined by distinct bacterial communities not driven by diet. Larger studies are needed to confirm these exploratory findings. View Full-Text
Keywords: trait mental fatigue and energy; trait physical fatigue and energy; gut microbiome; gut microbiota trait mental fatigue and energy; trait physical fatigue and energy; gut microbiome; gut microbiota
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MDPI and ACS Style

Boolani, A.; Gallivan, K.M.; Ondrak, K.S.; Christopher, C.J.; Castro, H.F.; Campagna, S.R.; Taylor, C.M.; Luo, M.; Dowd, S.E.; Smith, M.L.; Byerley, L.O. Trait Energy and Fatigue May Be Connected to Gut Bacteria among Young Physically Active Adults: An Exploratory Study. Nutrients 2022, 14, 466. https://doi.org/10.3390/nu14030466

AMA Style

Boolani A, Gallivan KM, Ondrak KS, Christopher CJ, Castro HF, Campagna SR, Taylor CM, Luo M, Dowd SE, Smith ML, Byerley LO. Trait Energy and Fatigue May Be Connected to Gut Bacteria among Young Physically Active Adults: An Exploratory Study. Nutrients. 2022; 14(3):466. https://doi.org/10.3390/nu14030466

Chicago/Turabian Style

Boolani, Ali, Karyn M. Gallivan, Kristin S. Ondrak, Courtney J. Christopher, Hector F. Castro, Shawn R. Campagna, Christopher M. Taylor, Meng Luo, Scot E. Dowd, Matthew L. Smith, and Lauri O. Byerley. 2022. "Trait Energy and Fatigue May Be Connected to Gut Bacteria among Young Physically Active Adults: An Exploratory Study" Nutrients 14, no. 3: 466. https://doi.org/10.3390/nu14030466

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