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Nutrients
Volume 14
Issue 2
10.3390/nu14020300
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Article

Oral Administration of Nicotinamide Mononucleotide Increases Nicotinamide Adenine Dinucleotide Level in an Animal Brain

by
Chidambaram Ramanathan
1,*,
Thomas Lackie
1,
Drake H. Williams
2,
Paul S. Simone
2,
Yufeng Zhang
1 and
Richard J. Bloomer
1
1
College of Health Sciences, University of Memphis, Memphis, TN 38152, USA
2
Department of Chemistry, University of Memphis, Memphis, TN 38152, USA
*
Author to whom correspondence should be addressed.
Academic Editor: Donald K. Ingram
Nutrients 2022, 14(2), 300; https://doi.org/10.3390/nu14020300
Received: 17 December 2021 / Revised: 7 January 2022 / Accepted: 9 January 2022 / Published: 12 January 2022
(This article belongs to the Section Nutrition and Metabolism)
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Abstract

As a redox-sensitive coenzyme, nicotinamide adenine dinucleotide (NAD+) plays a central role in cellular energy metabolism and homeostasis. Low NAD+ levels are linked to multiple disease states, including age-related diseases, such as metabolic and neurodegenerative diseases. Consequently, restoring/increasing NAD+ levels in vivo has emerged as an important intervention targeting age-related neurodegenerative diseases. One of the widely studied approaches to increase NAD+ levels in vivo is accomplished by using NAD+ precursors, such as nicotinamide mononucleotide (NMN). Oral administration of NMN has been shown to successfully increase NAD+ levels in a variety of tissues; however, it remains unclear whether NMN can cross the blood–brain barrier to increase brain NAD+ levels. This study evaluated the effects of oral NMN administration on NAD+ levels in C57/B6J mice brain tissues. Our results demonstrate that oral gavage of 400 mg/kg NMN successfully increases brain NAD+ levels in mice after 45 min. These findings provide evidence that NMN may be used as an intervention to increase NAD+ levels in the brain. View Full-Text
Keywords: NAD+; NMN; brain; oral gavage; mice NAD+; NMN; brain; oral gavage; mice
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MDPI and ACS Style

Ramanathan, C.; Lackie, T.; Williams, D.H.; Simone, P.S.; Zhang, Y.; Bloomer, R.J. Oral Administration of Nicotinamide Mononucleotide Increases Nicotinamide Adenine Dinucleotide Level in an Animal Brain. Nutrients 2022, 14, 300. https://doi.org/10.3390/nu14020300

AMA Style

Ramanathan C, Lackie T, Williams DH, Simone PS, Zhang Y, Bloomer RJ. Oral Administration of Nicotinamide Mononucleotide Increases Nicotinamide Adenine Dinucleotide Level in an Animal Brain. Nutrients. 2022; 14(2):300. https://doi.org/10.3390/nu14020300

Chicago/Turabian Style

Ramanathan, Chidambaram, Thomas Lackie, Drake H. Williams, Paul S. Simone, Yufeng Zhang, and Richard J. Bloomer. 2022. "Oral Administration of Nicotinamide Mononucleotide Increases Nicotinamide Adenine Dinucleotide Level in an Animal Brain" Nutrients 14, no. 2: 300. https://doi.org/10.3390/nu14020300

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