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Nutrients
Volume 14
Issue 19
10.3390/nu14193999
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Article

Trimester-Specific Serum Fructosamine in Association with Abdominal Adiposity, Insulin Resistance, and Inflammation in Healthy Pregnant Individuals

by
Emilie Bernier
1,2,3,
Amélie Lachance
1,2,4,
Anne-Sophie Plante
2,3,
Patricia Lemieux
3,5,
Karim Mourabit Amari
6,
S. John Weisnagel
3,5,
Claudia Gagnon
3,5,
Andréanne Michaud
1,2,4,
André Tchernof
1,2,4 and
Anne-Sophie Morisset
1,2,3,*
1
École de Nutrition, l’Université Laval, Québec, QC G1V 0A6, Canada
2
Centre Nutrition, Santé et Société (NUTRISS), l’Institut sur la Nutrition et les Aliments Fonctionnels (INAF), l’Université Laval, Québec, QC G1V 0A6, Canada
3
Axe Endocrinologie et Néphrologie, Centre de Recherche, CHU de Québec-Université Laval, Québec, QC G1V 4G2, Canada
4
Centre de Recherche de l’Institut Universitaire de Cardiologie et de Pneumologie, Québec-Université Laval, Québec, QC G1V 4G5, Canada
5
Département de Médecine, l’Université Laval, Québec, QC G1V 0A6, Canada
6
Département de Médecine de Laboratoire, CHU de Québec-Université Laval, Québec, QC G1V 4G5, Canada
*
Author to whom correspondence should be addressed.
Nutrients 2022, 14(19), 3999; https://doi.org/10.3390/nu14193999
Submission received: 23 August 2022 / Revised: 16 September 2022 / Accepted: 22 September 2022 / Published: 27 September 2022
(This article belongs to the Section Nutrition in Women)
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Abstract

This study aimed to (1) characterize the variations in serum fructosamine across trimesters and according to pre-pregnancy BMI (ppBMI), and (2) examine associations between fructosamine and adiposity/metabolic markers (ppBMI, first-trimester adiposity, leptin, glucose homeostasis, and inflammation measurements) during pregnancy. Serum fructosamine, albumin, fasting glucose and insulin, leptin, adiponectin, interleukin-6 (IL-6), and C-reactive protein (CRP) concentrations were measured at each trimester. In the first trimester, subcutaneous (SAT) and visceral (VAT) adipose tissue thicknesses were estimated by ultrasound. In the 101 healthy pregnant individuals included (age: 32.2 ± 3.5 y.o.; ppBMI: 25.5 ± 5.5 kg/m2), fructosamine concentrations decreased during pregnancy whereas albumin-corrected fructosamine concentrations increased (p < 0.0001 for both). Notably, fructosamine concentrations were inversely associated with ppBMI, first-trimester SAT, VAT, and leptin (r = −0.55, r = −0.61, r = −0.48, r = −0.47, respectively; p < 0.0001 for all), first-trimester fasting insulin and HOMA-IR (r = −0.46, r = −0.46; p < 0.0001 for both), and first-trimester IL-6 (r = −0.38, p < 0.01). However, once corrected for albumin, most of the correlations lost strength. Once adjusted for ppBMI, fructosamine concentrations were positively associated with third-trimester fasting glucose and CRP (r = 0.24, r = 0.27; p < 0.05 for both). In conclusion, serum fructosamine is inversely associated with adiposity before and during pregnancy, with markers of glucose homeostasis and inflammation, but the latter associations are partially influenced by albumin concentrations and ppBMI.
Keywords: pregnancy; fructosamine; adiposity; body fat distribution; glucose homeostasis; insulin resistance; gestational diabetes mellitus; inflammation pregnancy; fructosamine; adiposity; body fat distribution; glucose homeostasis; insulin resistance; gestational diabetes mellitus; inflammation

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MDPI and ACS Style

Bernier, E.; Lachance, A.; Plante, A.-S.; Lemieux, P.; Mourabit Amari, K.; Weisnagel, S.J.; Gagnon, C.; Michaud, A.; Tchernof, A.; Morisset, A.-S. Trimester-Specific Serum Fructosamine in Association with Abdominal Adiposity, Insulin Resistance, and Inflammation in Healthy Pregnant Individuals. Nutrients 2022, 14, 3999. https://doi.org/10.3390/nu14193999

AMA Style

Bernier E, Lachance A, Plante A-S, Lemieux P, Mourabit Amari K, Weisnagel SJ, Gagnon C, Michaud A, Tchernof A, Morisset A-S. Trimester-Specific Serum Fructosamine in Association with Abdominal Adiposity, Insulin Resistance, and Inflammation in Healthy Pregnant Individuals. Nutrients. 2022; 14(19):3999. https://doi.org/10.3390/nu14193999

Chicago/Turabian Style

Bernier, Emilie, Amélie Lachance, Anne-Sophie Plante, Patricia Lemieux, Karim Mourabit Amari, S. John Weisnagel, Claudia Gagnon, Andréanne Michaud, André Tchernof, and Anne-Sophie Morisset. 2022. "Trimester-Specific Serum Fructosamine in Association with Abdominal Adiposity, Insulin Resistance, and Inflammation in Healthy Pregnant Individuals" Nutrients 14, no. 19: 3999. https://doi.org/10.3390/nu14193999

APA Style

Bernier, E., Lachance, A., Plante, A.-S., Lemieux, P., Mourabit Amari, K., Weisnagel, S. J., Gagnon, C., Michaud, A., Tchernof, A., & Morisset, A.-S. (2022). Trimester-Specific Serum Fructosamine in Association with Abdominal Adiposity, Insulin Resistance, and Inflammation in Healthy Pregnant Individuals. Nutrients, 14(19), 3999. https://doi.org/10.3390/nu14193999

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