Persimmon Proanthocyanidins with Different Degrees of Polymerization Possess Distinct Activities in Models of High Fat Diet Induced Obesity
Abstract
:1. Introduction
2. Materials and Methods
2.1. Catalytic Hydrogenolysis of P-PCs
2.2. In Vivo Animal Study
2.2.1. Animals and Dosage Regimen
2.2.2. Glucose Tolerance Tests (GTTs)
2.2.3. Tissue Sample Collection
2.2.4. Biochemical Analyses and Histology
2.3. DNA Extraction and Information Analysis of Gut Microbiota
2.4. Enzyme Activity Assay
Fluorescence Quenching Measurements
2.5. Statistical Analysis
3. Results
3.1. P-PCs Administration Showed Stronger Potential on HFD Induced Weight Gain Compared with P-OPCs
3.2. P-PCs and P-OPCs Administration Improved Insulin Resistance
3.3. Dietary P-PCs and P-OPCs Reduce Lipid Accumulation in HFD Induced Obese Mice
3.4. Effect of P-PCs and P-OPCs on Gut Microbiota Diversity
3.5. Composition of the Gut Microbiota
3.5.1. Genus Level
3.5.2. Species Level
3.6. Inhibitory Activities of P-PCs and P-OPCs on Digestive Enzymes Activities
4. Discussion
5. Conclusions
Supplementary Materials
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Acknowledgments
Conflicts of Interest
References
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Yu, Y.; Chen, P.; Li, X.; Shen, S.; Li, K. Persimmon Proanthocyanidins with Different Degrees of Polymerization Possess Distinct Activities in Models of High Fat Diet Induced Obesity. Nutrients 2022, 14, 3718. https://doi.org/10.3390/nu14183718
Yu Y, Chen P, Li X, Shen S, Li K. Persimmon Proanthocyanidins with Different Degrees of Polymerization Possess Distinct Activities in Models of High Fat Diet Induced Obesity. Nutrients. 2022; 14(18):3718. https://doi.org/10.3390/nu14183718
Chicago/Turabian StyleYu, Ying, Ping Chen, Xiaofang Li, Shanshan Shen, and Kaikai Li. 2022. "Persimmon Proanthocyanidins with Different Degrees of Polymerization Possess Distinct Activities in Models of High Fat Diet Induced Obesity" Nutrients 14, no. 18: 3718. https://doi.org/10.3390/nu14183718