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Different Dose of Sucrose Consumption Divergently Influences Gut Microbiota and PPAR-γ/MAPK/NF-κB Pathway in DSS-Induced Colitis Mice

by 1,2,3, 1,3, 1,3, 1,3, 1,3, 1,3 and 1,3,*
1
Tianjin Key Laboratory of Food Science and Health, School of Medicine, Nankai University, Tianjin 300071, China
2
College of Food Science and Technology, Hebei Agricultural University, Baoding 071000, China
3
Institute of Public Health, Nankai University, Tianjin 300071, China
*
Author to whom correspondence should be addressed.
Academic Editor: Federica I. Wolf
Nutrients 2022, 14(13), 2765; https://doi.org/10.3390/nu14132765
Received: 10 May 2022 / Revised: 2 July 2022 / Accepted: 2 July 2022 / Published: 4 July 2022
(This article belongs to the Section Carbohydrates)
Sugar reduction and sugar control are advocated and gaining popularity around the world. Sucrose, as the widely consumed ingredient in our daily diet, has been reported a relation to gastrointestinal diseases. However, the role of sucrose in inflammatory bowel disease remains controversial. Hence, our study aimed to elucidate the potential role of three doses of sucrose on DSS-induced colitis in C57BL/6 mice and the underlying mechanisms. The results showed that low-dose sucrose intervention alleviated colitis in mice, reducing the expression of inflammatory cytokines and repairing mucosal damages. In contrast, high-dose sucrose intervention exacerbated colitis. Furthermore, three doses of sucrose administration markedly altered gut microbiota composition. Notably, the low-dose sucrose restored microbial dysfunction and enhanced the production of short chain fatty acids (SCFAs). Specifically, the abundance of SCFAs-producing bacteria Faecalibaculum, Bacteroides, and Romboutsia were increased significantly in the LOW group. Consistently, PPAR-γ, activated by SCFAs, was elevated in the LOW group, thereby inhibiting the MAPK/NF-κB pathway. Together, our study demonstrates the differential effects of sucrose on colitis at different doses, providing a scientific basis for measuring and modifying the safe intake level of sugar and providing favorable evidence for implementing sugar reduction policies. View Full-Text
Keywords: sucrose; gut microbiota; SCFAs; PPAR-γ; MAPK/NF-κB sucrose; gut microbiota; SCFAs; PPAR-γ; MAPK/NF-κB
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MDPI and ACS Style

Zhang, X.; Zhang, B.; Peng, B.; Wang, J.; Hu, Y.; Wang, R.; Wang, S. Different Dose of Sucrose Consumption Divergently Influences Gut Microbiota and PPAR-γ/MAPK/NF-κB Pathway in DSS-Induced Colitis Mice. Nutrients 2022, 14, 2765. https://doi.org/10.3390/nu14132765

AMA Style

Zhang X, Zhang B, Peng B, Wang J, Hu Y, Wang R, Wang S. Different Dose of Sucrose Consumption Divergently Influences Gut Microbiota and PPAR-γ/MAPK/NF-κB Pathway in DSS-Induced Colitis Mice. Nutrients. 2022; 14(13):2765. https://doi.org/10.3390/nu14132765

Chicago/Turabian Style

Zhang, Xuejiao, Bowei Zhang, Bo Peng, Jin Wang, Yaozhong Hu, Ruican Wang, and Shuo Wang. 2022. "Different Dose of Sucrose Consumption Divergently Influences Gut Microbiota and PPAR-γ/MAPK/NF-κB Pathway in DSS-Induced Colitis Mice" Nutrients 14, no. 13: 2765. https://doi.org/10.3390/nu14132765

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