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Article

Vitamin D and Risk of Obesity-Related Cancers: Results from the SUN (‘Seguimiento Universidad de Navarra’) Project

1
Medical Oncology Department, Hospital Universitario 12 de Octubre, 28041 Madrid, Spain
2
Department of Preventive Medicine and Public Health, School of Medicine, University of Navarra, 31008 Pamplona, Spain
3
Centro de Investigación Biomédica en Red Área de Fisiología de la Obesidad y la Nutrición (CIBEROBN), INSTITUTO DE SALUD CARLOS III, 28029 Madrid, Spain
4
IdiSNA, Navarra Institute for Health Research, 31008 Pamplona, Spain
5
Department of History, Art History, and Geography, University of Navarra, 31008 Pamplona, Spain
*
Author to whom correspondence should be addressed.
Academic Editor: Dariusz Nowak
Nutrients 2022, 14(13), 2561; https://doi.org/10.3390/nu14132561
Received: 27 May 2022 / Revised: 17 June 2022 / Accepted: 19 June 2022 / Published: 21 June 2022
(This article belongs to the Special Issue The Role of Vitamin D in Cancer Prevention)
Obesity is associated with a higher risk of several types of cancer, grouped as obesity-related cancers (ORC). Vitamin D deficiency is more prevalent in obese subjects, and it has been suggested to play a role in the association between obesity and cancer risk. The aim of the study was to analyze the association between vitamin D intake and the subsequent risk of ORC in a prospective Spanish cohort of university graduates. The SUN Project, initiated in 1999, is a prospective dynamic multipurpose cohort. Participants answered a 556-item lifestyle baseline questionnaire that included a validated food-frequency questionnaire. We performed Cox regression models to estimate the hazard ratios (HRs) of ORC according to quartiles of energy-adjusted vitamin D intake (diet and supplements). We included 18,017 participants (mean age = 38 years, SD = 12 years), with a median follow-up of 12 years. Among 206,783 person-years of follow-up, we identified 225 cases of ORC. We found no significant associations between vitamin D intake and ORC risk after adjusting for potential confounders: HRQ2vsQ1 = 1.19 (95% CI 0.81–1.75), HRQ3vsQ1 = 1.20 (95% CI 0.81–1.78), and HRQ4vsQ1 = 1.02 (95% CI 0.69–1.51). Dietary and supplemented vitamin D do not seem to be associated with ORC prevention in the middle-aged Spanish population. View Full-Text
Keywords: obesity; cancer; vitamin D; cohort obesity; cancer; vitamin D; cohort
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MDPI and ACS Style

Sánchez-Bayona, R.; Bes-Rastrollo, M.; Fernández-Lázaro, C.I.; Bastyr, M.; Madariaga, A.; Pons, J.J.; Martínez-González, M.A.; Toledo, E. Vitamin D and Risk of Obesity-Related Cancers: Results from the SUN (‘Seguimiento Universidad de Navarra’) Project. Nutrients 2022, 14, 2561. https://doi.org/10.3390/nu14132561

AMA Style

Sánchez-Bayona R, Bes-Rastrollo M, Fernández-Lázaro CI, Bastyr M, Madariaga A, Pons JJ, Martínez-González MA, Toledo E. Vitamin D and Risk of Obesity-Related Cancers: Results from the SUN (‘Seguimiento Universidad de Navarra’) Project. Nutrients. 2022; 14(13):2561. https://doi.org/10.3390/nu14132561

Chicago/Turabian Style

Sánchez-Bayona, Rodrigo, Maira Bes-Rastrollo, Cesar I. Fernández-Lázaro, Maite Bastyr, Ainhoa Madariaga, Juan J. Pons, Miguel A. Martínez-González, and Estefanía Toledo. 2022. "Vitamin D and Risk of Obesity-Related Cancers: Results from the SUN (‘Seguimiento Universidad de Navarra’) Project" Nutrients 14, no. 13: 2561. https://doi.org/10.3390/nu14132561

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