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Article

Dietary Gamma-Aminobutyric Acid (GABA) Induces Satiation by Enhancing the Postprandial Activation of Vagal Afferent Nerves

1
Department of Research and Development, Pharma Foods International Co., Ltd., 1-49 Goryo-Ohara, Nishikyo-ku, Kyoto 615-8245, Japan
2
Laboratory of Animal Science, Graduate School of Life and Environmental Sciences, Kyoto Prefectural University, 1-5 Hangi-cho, Shimogamo, Sakyo-ku, Kyoto 606-8522, Japan
3
Laboratory of Functional Anatomy, Faculty of Agriculture, Kyushu University, 744 Motooka, Nishi-ku, Fukuoka 819-0395, Japan
*
Author to whom correspondence should be addressed.
These authors contributed equally to this work.
Academic Editor: Adam Rose
Nutrients 2022, 14(12), 2492; https://doi.org/10.3390/nu14122492
Received: 5 May 2022 / Revised: 6 June 2022 / Accepted: 13 June 2022 / Published: 16 June 2022
Gamma-aminobutyric acid (GABA) is present in the mammalian brain as the main inhibitory neurotransmitter and in foods. It is widely used as a supplement that regulates brain function through stress-reducing and sleep-enhancing effects. However, its underlying mechanisms remain poorly understood, as it is reportedly unable to cross the blood–brain barrier. Here, we explored whether a single peroral administration of GABA affects feeding behavior as an evaluation of brain function and the involvement of vagal afferent nerves. Peroral GABA at 20 and 200 mg/kg immediately before refeeding suppressed short-term food intake without aversive behaviors in mice. However, GABA administration 30 min before refeeding demonstrated no effects. A rise in circulating GABA concentrations by the peroral administration of 200 mg/kg GABA was similar to that by the intraperitoneal injection of 20 mg/kg GABA, which did not alter feeding. The feeding suppression by peroral GABA was blunted by the denervation of vagal afferents. Unexpectedly, peroral GABA alone did not alter vagal afferent activities histologically. The coadministration of a liquid diet and GABA potentiated the postprandial activation of vagal afferents, thereby enhancing postprandial satiation. In conclusion, dietary GABA activates vagal afferents in collaboration with meals or meal-evoked factors and regulates brain function including feeding behavior. View Full-Text
Keywords: GABA; dietary GABA; vagal afferents; nodose ganglion; food intake; postprandial satiation; vagotomy; capsaicin-sensitive sensory nerves; ERK GABA; dietary GABA; vagal afferents; nodose ganglion; food intake; postprandial satiation; vagotomy; capsaicin-sensitive sensory nerves; ERK
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MDPI and ACS Style

Nakamura, U.; Nohmi, T.; Sagane, R.; Hai, J.; Ohbayashi, K.; Miyazaki, M.; Yamatsu, A.; Kim, M.; Iwasaki, Y. Dietary Gamma-Aminobutyric Acid (GABA) Induces Satiation by Enhancing the Postprandial Activation of Vagal Afferent Nerves. Nutrients 2022, 14, 2492. https://doi.org/10.3390/nu14122492

AMA Style

Nakamura U, Nohmi T, Sagane R, Hai J, Ohbayashi K, Miyazaki M, Yamatsu A, Kim M, Iwasaki Y. Dietary Gamma-Aminobutyric Acid (GABA) Induces Satiation by Enhancing the Postprandial Activation of Vagal Afferent Nerves. Nutrients. 2022; 14(12):2492. https://doi.org/10.3390/nu14122492

Chicago/Turabian Style

Nakamura, Utano, Taichi Nohmi, Riho Sagane, Jun Hai, Kento Ohbayashi, Maiko Miyazaki, Atsushi Yamatsu, Mujo Kim, and Yusaku Iwasaki. 2022. "Dietary Gamma-Aminobutyric Acid (GABA) Induces Satiation by Enhancing the Postprandial Activation of Vagal Afferent Nerves" Nutrients 14, no. 12: 2492. https://doi.org/10.3390/nu14122492

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