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Article

Glycaemia Fluctuations Improvement in Old-Age Prediabetic Subjects Consuming a Quinoa-Based Diet: A Pilot Study

1
Faculty of Health Science, Universitat Oberta de Catalunya, 08018 Barcelona, Spain
2
Primary Healthcare Transversal Research Group, IDIBAPS, 08036 Barcelona, Spain
3
Department of Statistics and Operation Research, Universitat Politecnica de Catalunya, 08034 Barcelona, Spain
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Primary Care Center Les Corts, CAPSBE, 08036 Barcelona, Spain
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Department of Health and Alimentary Habits, Alicia-elBulli Foundation, Sant Fruitós de Bages, 08272 Barcelona, Spain
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Diabetes and Obesity Research Laboratory, IDIBAPS–Hospital Clinic of Barcelona, 08036 Barcelona, Spain
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Centro de Investigación Biomédica en Red de Diabetes y Enfermedades Metabólicas Asociadas (CIBERDEM), 28029 Madrid, Spain
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Department of Endocrinology and Nutrition, Hospital Clinic of Barcelona, 08036 Barcelona, Spain
*
Author to whom correspondence should be addressed.
Academic Editor: Patrick R. M. Lauwers
Nutrients 2022, 14(11), 2331; https://doi.org/10.3390/nu14112331
Received: 18 March 2022 / Revised: 25 May 2022 / Accepted: 26 May 2022 / Published: 1 June 2022
(This article belongs to the Special Issue Nutrition and Glucose Homeostasis)
This study aimed to observe if quinoa could produce a benefit on postprandial glycemia that would result in less progression to type 2 diabetes (T2D). A cross-over design pilot clinical study with a nutritional intervention for 8 weeks was performed: 4 weeks on a regular diet (RD) and 4 weeks on a quinoa diet (QD). Nine subjects aged ≥65 years with prediabetes were monitored during the first 4 weeks of RD with daily dietary records and FreeStyle Libre®. Subsequently, participants started the QD, where quinoa and 100% quinoa-based products replaced foods rich in complex carbohydrates that they had consumed in the first 4 weeks of RD. The glycemic measurements recorded by the sensors were considered as functions of time, and the effects of nutrients consumed at the intended time period were analyzed by means of a function-on-scalar regression (fosr) model. With QD participants, decreased body weight (−1.6 kg, p = 0.008), BMI (−0.6 kg/m2p = 0.004) and waist circumference (−1.5 cm, p = 0.015) were observed. Nutrients intake changed during QD, namely, decreased carbohydrates (p = 0.004) and increased lipids (p = 0.004) and some amino acids (p < 0.05). The fosr model showed a reduction in postprandial glycemia in QD despite intrapersonal differences thanks to the joint action of different nutrients and the suppression of others consumed on a regular diet. We conclude that in an old age and high T2D-risk population, a diet rich in quinoa reduces postprandial glycemia and could be a promising T2D-preventive strategy. View Full-Text
Keywords: nutrition; diabetes; quinoa; diet; prevention; glycaemia nutrition; diabetes; quinoa; diet; prevention; glycaemia
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MDPI and ACS Style

Díaz-Rizzolo, D.A.; Acar-Denizli, N.; Kostov, B.; Roura, E.; Sisó-Almirall, A.; Delicado, P.; Gomis, R. Glycaemia Fluctuations Improvement in Old-Age Prediabetic Subjects Consuming a Quinoa-Based Diet: A Pilot Study. Nutrients 2022, 14, 2331. https://doi.org/10.3390/nu14112331

AMA Style

Díaz-Rizzolo DA, Acar-Denizli N, Kostov B, Roura E, Sisó-Almirall A, Delicado P, Gomis R. Glycaemia Fluctuations Improvement in Old-Age Prediabetic Subjects Consuming a Quinoa-Based Diet: A Pilot Study. Nutrients. 2022; 14(11):2331. https://doi.org/10.3390/nu14112331

Chicago/Turabian Style

Díaz-Rizzolo, Diana A., Nihan Acar-Denizli, Belchin Kostov, Elena Roura, Antoni Sisó-Almirall, Pedro Delicado, and Ramon Gomis. 2022. "Glycaemia Fluctuations Improvement in Old-Age Prediabetic Subjects Consuming a Quinoa-Based Diet: A Pilot Study" Nutrients 14, no. 11: 2331. https://doi.org/10.3390/nu14112331

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