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Article

Metabolomic Profile of Different Dietary Patterns and Their Association with Frailty Index in Community-Dwelling Older Men and Women

1
Longitudinal Studies Section, National Institute on Aging, Baltimore, MD 21224, USA
2
Department of Exercise and Nutrition Sciences, Milken Institute School of Public Health, The George Washington University, Washington, DC 20052, USA
3
Laboratory of Clinical Investigation, National Institute on Aging, Baltimore, MD 21224, USA
*
Author to whom correspondence should be addressed.
Academic Editors: Arrigo Cicero, Federica Fogacci and Claudio Borghi
Nutrients 2022, 14(11), 2237; https://doi.org/10.3390/nu14112237
Received: 10 May 2022 / Revised: 23 May 2022 / Accepted: 25 May 2022 / Published: 27 May 2022
Diet quality has been associated with slower rates of aging; however, the mechanisms underlying the role of a healthy diet in aging are not fully understood. To address this question, we aimed to identify plasma metabolomic biomarkers of dietary patterns and explored whether these metabolites mediate the relationship between diet and healthy aging, as assessed by the frailty index (FI) in 806 participants of the Baltimore Longitudinal Study of Aging. Adherence to different dietary patterns was evaluated using the Mediterranean diet score (MDS), Mediterranean–DASH Diet Intervention for Neurodegenerative Delay (MIND) score, and Alternate Healthy Eating Index-2010 (AHEI). Associations between diet, FI, and metabolites were assessed using linear regression models. Higher adherence to these dietary patterns was associated with lower FI. We found 236, 218, and 278 metabolites associated with the MDS, MIND, and AHEI, respectively, with 127 common metabolites, which included lipids, tri/di-glycerides, lyso/phosphatidylcholine, amino acids, bile acids, ceramides, cholesterol esters, fatty acids and acylcarnitines, indoles, and sphingomyelins. Metabolomic signatures of diet explained 28%, 37%, and 38% of the variance of the MDS, MIND, and AHEI, respectively. Signatures of MIND and AHEI mediated 55% and 61% of the association between each dietary pattern with FI, while the mediating effect of MDS signature was not statistically significant. The high number of metabolites associated with the different dietary patterns supports the notion of common mechanisms that underly the relationship between diet and frailty. The identification of multiple metabolite classes suggests that the effect of diet is complex and not mediated by any specific biomarkers. Furthermore, these metabolites may serve as biomarkers for poor diet quality to identify individuals for targeted dietary interventions. View Full-Text
Keywords: dietary patterns; metabolomics; frailty; mediation; aging dietary patterns; metabolomics; frailty; mediation; aging
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MDPI and ACS Style

Tanaka, T.; Talegawkar, S.A.; Jin, Y.; Candia, J.; Tian, Q.; Moaddel, R.; Simonsick, E.M.; Ferrucci, L. Metabolomic Profile of Different Dietary Patterns and Their Association with Frailty Index in Community-Dwelling Older Men and Women. Nutrients 2022, 14, 2237. https://doi.org/10.3390/nu14112237

AMA Style

Tanaka T, Talegawkar SA, Jin Y, Candia J, Tian Q, Moaddel R, Simonsick EM, Ferrucci L. Metabolomic Profile of Different Dietary Patterns and Their Association with Frailty Index in Community-Dwelling Older Men and Women. Nutrients. 2022; 14(11):2237. https://doi.org/10.3390/nu14112237

Chicago/Turabian Style

Tanaka, Toshiko, Sameera A. Talegawkar, Yichen Jin, Julián Candia, Qu Tian, Ruin Moaddel, Eleanor M. Simonsick, and Luigi Ferrucci. 2022. "Metabolomic Profile of Different Dietary Patterns and Their Association with Frailty Index in Community-Dwelling Older Men and Women" Nutrients 14, no. 11: 2237. https://doi.org/10.3390/nu14112237

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