Next Article in Journal
Enteral Nutrition Overview
Previous Article in Journal
Reduction of De Novo Lipogenesis Mediates Beneficial Effects of Isoenergetic Diets on Fatty Liver: Mechanistic Insights from the MEDEA Randomized Clinical Trial
Previous Article in Special Issue
Mild Endurance Exercise during Fasting Increases Gastrocnemius Muscle and Prefrontal Cortex Thyroid Hormone Levels through Differential BHB and BCAA-Mediated BDNF-mTOR Signaling in Rats
 
 
Article

Resistance Exercise Training Improves Metabolic and Inflammatory Control in Adipose and Muscle Tissues in Mice Fed a High-Fat Diet

1
Faculty of Sports Science, Ningbo University, Ningbo 315211, China
2
Graduate Program in Health Science, Medical School, Universidade do Extremo Sul Catarinense, Criciúma 88806-000, SC, Brazil
3
Graduate de Pós-graduação em Farmacologia, Universidade Federal de Santa Catarina, Florianópolis 88020-302, SC, Brazil
4
Health Research Centre, School of Kinesiology and Health Science, York University, Toronto, ON M3J 1P3, Canada
5
Laboratory of Exercise Biochemistry in Health, Graduate Program in Health Sciences, School of Medicine, Pontifícia Universidade Católica do Paraná, Curitiba 80215-901, PR, Brazil
6
Graduate Program in Cellular and Molecular Biology, School of Health and Life Sciences, Pontifical Catholic University of Rio Grande do Sul, Porto Alegre 90619-900, RS, Brazil
7
Graduate Program in Medicine and Health Sciences, School of Medicine, Pontifical Catholic University of Rio Grande do Sul, Porto Alegre 90619-900, RS, Brazil
*
Authors to whom correspondence should be addressed.
Academic Editors: Elena Silvestri, Antonia Giacco and Susanne Klaus
Nutrients 2022, 14(11), 2179; https://doi.org/10.3390/nu14112179
Received: 7 April 2022 / Revised: 19 May 2022 / Accepted: 20 May 2022 / Published: 24 May 2022
This study investigates whether ladder climbing (LC), as a model of resistance exercise, can reverse whole-body and skeletal muscle deleterious metabolic and inflammatory effects of high-fat (HF) diet-induced obesity in mice. To accomplish this, Swiss mice were fed for 17 weeks either standard chow (SC) or an HF diet and then randomly assigned to remain sedentary or to undergo 8 weeks of LC training with progressive increases in resistance weight. Prior to beginning the exercise intervention, HF-fed animals displayed a 47% increase in body weight (BW) and impaired ability to clear blood glucose during an insulin tolerance test (ITT) when compared to SC animals. However, 8 weeks of LC significantly reduced BW, adipocyte size, as well as glycemia under fasting and during the ITT in HF-fed rats. LC also increased the phosphorylation of AktSer473 and AMPKThr172 and reduced tumor necrosis factor-alpha (TNF-α) and interleukin 1 beta (IL1-β) contents in the quadriceps muscles of HF-fed mice. Additionally, LC reduced the gene expression of inflammatory markers and attenuated HF-diet-induced NADPH oxidase subunit gp91phox in skeletal muscles. LC training was effective in reducing adiposity and the content of inflammatory mediators in skeletal muscle and improved whole-body glycemic control in mice fed an HF diet. View Full-Text
Keywords: physical exercise; ladder-climbing training; inflammation; insulin resistance; obesity physical exercise; ladder-climbing training; inflammation; insulin resistance; obesity
Show Figures

Figure 1

MDPI and ACS Style

Effting, P.S.; Thirupathi, A.; Müller, A.P.; Pereira, B.C.; Sepa-Kishi, D.M.; Marqueze, L.F.B.; Vasconcellos, F.T.F.; Nesi, R.T.; Pereira, T.C.B.; Kist, L.W.; Bogo, M.R.; Ceddia, R.B.; Pinho, R.A. Resistance Exercise Training Improves Metabolic and Inflammatory Control in Adipose and Muscle Tissues in Mice Fed a High-Fat Diet. Nutrients 2022, 14, 2179. https://doi.org/10.3390/nu14112179

AMA Style

Effting PS, Thirupathi A, Müller AP, Pereira BC, Sepa-Kishi DM, Marqueze LFB, Vasconcellos FTF, Nesi RT, Pereira TCB, Kist LW, Bogo MR, Ceddia RB, Pinho RA. Resistance Exercise Training Improves Metabolic and Inflammatory Control in Adipose and Muscle Tissues in Mice Fed a High-Fat Diet. Nutrients. 2022; 14(11):2179. https://doi.org/10.3390/nu14112179

Chicago/Turabian Style

Effting, Pauline S., Anand Thirupathi, Alexandre P. Müller, Bárbara C. Pereira, Diane M. Sepa-Kishi, Luis F. B. Marqueze, Franciane T. F. Vasconcellos, Renata T. Nesi, Talita C. B. Pereira, Luiza W. Kist, Maurício R. Bogo, Rolando B. Ceddia, and Ricardo A. Pinho. 2022. "Resistance Exercise Training Improves Metabolic and Inflammatory Control in Adipose and Muscle Tissues in Mice Fed a High-Fat Diet" Nutrients 14, no. 11: 2179. https://doi.org/10.3390/nu14112179

Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Back to TopTop