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Article

Gastro-Protective Effect of Fermented Soybean (Glycine max (L.) Merr.) in a Rat Model of Ethanol/HCl-Induced Gastric Injury

1
Department of Medical Nutrition, Kyung Hee University, Yongin 17104, Korea
2
Cosmax NBT, Inc., Seongnam-si 13486, Korea
3
Bision Corporation, Seoul 05854, Korea
4
Division of Food and Nutrition and Human Ecology Research Institute, Chonnam National University, Gwangju 61186, Korea
5
Research Institute of Clinical Nutrition, Kyung Hee University, Seoul 02447, Korea
*
Authors to whom correspondence should be addressed.
Academic Editors: M. Luisa Bonet and Lindsay Brown
Nutrients 2022, 14(10), 2079; https://doi.org/10.3390/nu14102079
Received: 5 April 2022 / Revised: 13 May 2022 / Accepted: 13 May 2022 / Published: 16 May 2022
(This article belongs to the Section Nutrigenetics and Nutrigenomics)
The present research purposed to examine the gastro-protective effect of Glycine max (L.) Merr. fermented using Lactobacillus delbrueckii ssp. delbrueckii Rosell-187 (Gastro-AD®) on ethanol/HCl-induced gastric damage, specifically on gastric acid secretion. After oral supplementation of Gastro-AD® to Sprague–Dawley (SD) rats with ethanol/HCl-induced gastric damage, we determined that Gastro-AD® attenuated the gastric mucosal lesion, hemorrhage and gastric acid secretion induced by ethanol/HCl. In addition, we observed that the Gastro-AD® treatment increased the serum prostaglandin E2 level and decreased the levels of gastric acid secretion-related receptors in both gastric tissues and primary gastric parietal cells. Furthermore, it decreased the levels of inflammatory factors, including serum histamine and expression of p-IκB, p-p65, iNOS and COX-2 and the activity of apoptotic signaling pathways, including those involving p-JNK, Bcl2/Bax, Fas, FADD, caspase-8 and caspase-3, in the stomach of the ethanol/HCl-treated rats. Thus, we suggest that Gastro-AD® supplementation may reduce ethanol/HCl-induced gastric acid secretion and prevent gastric injury. View Full-Text
Keywords: Glycine max (L.) Merr.; gastric damage; gastric ulcer Glycine max (L.) Merr.; gastric damage; gastric ulcer
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MDPI and ACS Style

Lee, M.; Kim, D.; Kim, H.; Jo, S.; Kim, O.-K.; Lee, J. Gastro-Protective Effect of Fermented Soybean (Glycine max (L.) Merr.) in a Rat Model of Ethanol/HCl-Induced Gastric Injury. Nutrients 2022, 14, 2079. https://doi.org/10.3390/nu14102079

AMA Style

Lee M, Kim D, Kim H, Jo S, Kim O-K, Lee J. Gastro-Protective Effect of Fermented Soybean (Glycine max (L.) Merr.) in a Rat Model of Ethanol/HCl-Induced Gastric Injury. Nutrients. 2022; 14(10):2079. https://doi.org/10.3390/nu14102079

Chicago/Turabian Style

Lee, Minhee, Dakyung Kim, Hyunji Kim, Sukyung Jo, Ok-Kyung Kim, and Jeongmin Lee. 2022. "Gastro-Protective Effect of Fermented Soybean (Glycine max (L.) Merr.) in a Rat Model of Ethanol/HCl-Induced Gastric Injury" Nutrients 14, no. 10: 2079. https://doi.org/10.3390/nu14102079

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