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Article

Low Serum Vitamin D in COVID-19 Patients Is Not Related to Inflammatory Markers and Patients’ Outcomes—A Single-Center Experience and a Brief Review of the Literature

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Department of Laboratory Medicine, George Emil Palade University of Medicine, Pharmacy, Science, and Technology of Targu Mures, 540142 Targu Mures, Romania
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Department of Laboratory Medicine, Emergency Clinical County Hospital Targu Mures, 540136 Targu Mures, Romania
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Department of Infectious Diseases, George Emil Palade University of Medicine, Pharmacy, Science, and Technology of Targu Mures, 540142 Targu Mures, Romania
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Department of Epidemiology, George Emil Palade University of Medicine, Pharmacy, Science, and Technology of Targu Mures, 540136 Targu Mures, Romania
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Center for Advanced Medical and Pharmaceutical Research, George Emil Palade University of Medicine, Pharmacy, Science, and Technology of Targu Mures, 540136 Targu Mures, Romania
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Author to whom correspondence should be addressed.
Academic Editor: Tyler Barker
Nutrients 2022, 14(10), 1998; https://doi.org/10.3390/nu14101998
Received: 3 April 2022 / Revised: 30 April 2022 / Accepted: 7 May 2022 / Published: 10 May 2022
The aim of the study was to evaluate the vitamin D status in hospitalized COVID-19 patients and the correlation with C reactive protein (CRP), ferritin, fibrinogen, and peripheral blood leukocytes, as well as inflammatory derived indices. A prospective study was performed on 203 COVID-19 hospitalized patients, classified by disease severity. Blood was collected after admission, and inflammatory biomarkers and vitamin D status were assessed using routine laboratory procedures. No significant correlation was found between vitamin D serum levels and disease severity stratified by different age groups. However, the highest vitamin D levels were found in patients with mild disease: median 29.39 (IQR 12.12–44.02) ng/mL, while for moderate and severe forms the serum levels were significantly lower: median 15.10 (IQR 9.56–24.11) ng/mL for moderate, and 18.86 (IQR 12.50–27.88) ng/mL for severe; p = 0.009. Patients with no comorbidities showed a significantly higher level of vitamin D median 24.72 (IQR 16.05–31.52) ng/mL compared to subjects with at least one comorbidity: median 16.02 (IQR 9.81–25.22) ng/mL, p = 0.004. We did not find an association between vitamin D levels and inflammatory biomarkers except for significantly lower vitamin D levels in moderate and severe COVID-19 compared to mild disease forms. View Full-Text
Keywords: COVID-19; inflammation; vitamin D COVID-19; inflammation; vitamin D
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MDPI and ACS Style

Huțanu, A.; Georgescu, A.M.; Voidăzan, S.; Andrejkovits, A.V.; Negrea, V.; Dobreanu, M. Low Serum Vitamin D in COVID-19 Patients Is Not Related to Inflammatory Markers and Patients’ Outcomes—A Single-Center Experience and a Brief Review of the Literature. Nutrients 2022, 14, 1998. https://doi.org/10.3390/nu14101998

AMA Style

Huțanu A, Georgescu AM, Voidăzan S, Andrejkovits AV, Negrea V, Dobreanu M. Low Serum Vitamin D in COVID-19 Patients Is Not Related to Inflammatory Markers and Patients’ Outcomes—A Single-Center Experience and a Brief Review of the Literature. Nutrients. 2022; 14(10):1998. https://doi.org/10.3390/nu14101998

Chicago/Turabian Style

Huțanu, Adina, Anca M. Georgescu, Septimiu Voidăzan, Akos V. Andrejkovits, Valentina Negrea, and Minodora Dobreanu. 2022. "Low Serum Vitamin D in COVID-19 Patients Is Not Related to Inflammatory Markers and Patients’ Outcomes—A Single-Center Experience and a Brief Review of the Literature" Nutrients 14, no. 10: 1998. https://doi.org/10.3390/nu14101998

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