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Effect of Standardized Hydrangea serrata (Thunb.) Ser. Leaves Extract on Body Weight and Body Fat Reduction in Overweight or Obese Humans: A Randomized Double-Blind Placebo-Controlled Study

1
Department of Pharmaceutical Biochemistry, College of Pharmacy, Kyung Hee University, Seoul 02447, Korea
2
Department of Life and Nanopharmaceutical Sciences, Graduate School, Kyung Hee University, Seoul 02447, Korea
3
Department of New Material Development, COSMAXBIO, Seongnam 13486, Korea
4
Clinical Research Center of H PLUS Yangji Hospital, Sillim-dong, Gwanak-gu, Seoul 08779, Korea
*
Authors to whom correspondence should be addressed.
Academic Editor: R. Andrew Shanely
Nutrients 2022, 14(1), 208; https://doi.org/10.3390/nu14010208
Received: 7 December 2021 / Revised: 27 December 2021 / Accepted: 31 December 2021 / Published: 3 January 2022
(This article belongs to the Section Phytochemicals and Human Health)
Obesity is a major health problem that is caused by body fat accumulation and that can lead to metabolic diseases. Owing to several side effects of the currently used antiobesity drugs, natural plants have risen as safe and potential candidates to alleviate obesity. We have previously reported the antiobesity effect of Hydrangea serrata (Thunb.) Ser. leaves extract (WHS) and its underlying mechanisms. As an extension of our preclinical studies, this study aimed to investigate the effect of WHS on body weight and body fat reduction in overweight or obese humans. A total of 93 healthy overweight or obese males and females, aged 19–65 years, with body mass indexes (BMIs) ≥ 25 and <32 kg/m2, were recruited and received either an oral administration of 600 mg of WHS, or placebo tablets for 12 weeks. Daily supplementation with WHS decreased body weights, body fat masses, and BMIs compared with the placebo-treated group. The hip circumferences, visceral fat areas, abdominal fat areas, and visceral-to-subcutaneous ratios decreased after WHS supplementation. No significant side effects were observed during or after the 12 weeks of WHS intake. In conclusion, WHS, which has beneficial effects on body weight and body fat reduction, could be a promising antiobesity supplement that does not produce any side effects. View Full-Text
Keywords: Hydrangea serrata (Thunb.) Ser.; obesity; body weight; body fat; clinical trial Hydrangea serrata (Thunb.) Ser.; obesity; body weight; body fat; clinical trial
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MDPI and ACS Style

Han, H.-S.; Chung, K.-S.; Shin, Y.-K.; Yu, J.-S.; Kang, S.-H.; Lee, S.-H.; Lee, K.-T. Effect of Standardized Hydrangea serrata (Thunb.) Ser. Leaves Extract on Body Weight and Body Fat Reduction in Overweight or Obese Humans: A Randomized Double-Blind Placebo-Controlled Study. Nutrients 2022, 14, 208. https://doi.org/10.3390/nu14010208

AMA Style

Han H-S, Chung K-S, Shin Y-K, Yu J-S, Kang S-H, Lee S-H, Lee K-T. Effect of Standardized Hydrangea serrata (Thunb.) Ser. Leaves Extract on Body Weight and Body Fat Reduction in Overweight or Obese Humans: A Randomized Double-Blind Placebo-Controlled Study. Nutrients. 2022; 14(1):208. https://doi.org/10.3390/nu14010208

Chicago/Turabian Style

Han, Hee-Soo, Kyung-Sook Chung, Yu-Kyong Shin, Jae-Sik Yu, Seung-Hyun Kang, Sun-Hee Lee, and Kyung-Tae Lee. 2022. "Effect of Standardized Hydrangea serrata (Thunb.) Ser. Leaves Extract on Body Weight and Body Fat Reduction in Overweight or Obese Humans: A Randomized Double-Blind Placebo-Controlled Study" Nutrients 14, no. 1: 208. https://doi.org/10.3390/nu14010208

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