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Article

A Pilot Randomized Controlled Trial of a Partial Meal Replacement Preconception Weight Loss Program for Women with Overweight and Obesity

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Charles Perkins Centre, School of Life and Environmental Biosciences, University of Sydney, Sydney, NSW 2006, Australia
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Charles Perkins Centre, University of Sydney, Sydney, NSW 2006, Australia
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Speciality of Obstetrics, Gynaecology and Neonatology, Central Clinical School, Faculty of Medicine and Health, Charles Perkins Centre, University of Sydney, Sydney, NSW 2006, Australia
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Department of Women and Babies, Royal Prince Alfred Hospital, Sydney Local Health District, Sydney, NSW 2050, Australia
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Charles Perkins Centre, Childrens Hospital Westmead Clinical School, University of Sydney, Sydney, NSW 2006, Australia
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School of Human Sciences, Faculty of Science, University of Western Australia, Crawley, WA 6009, Australia
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Sydney Medical School, The University of Sydney, NSW 2006, Australia
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Charles Perkins Centre, Boden Initiative, The University of Sydney, NSW 2006, Australia
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Department of Endocrinology, Royal Prince Alfred Hospital, NSW 2050, Australia
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Speciality of Obstetrics, Gynaecology and Neonatology, Central Clinical School, Faculty of Medicine and Health, Royal Prince Alfred Hospital Newborn Care, Sydney Local Health District, Sydney, NSW 2050, Australia
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Clinical Trial Centre, Department of Neonatology, University of Sydney, Westmead Hospital, Sydney, NSW 2006, Australia
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Sydney Medical School, Charles Perkins Centre, University of Sydney, Camperdown, NSW 2006, Australia
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Royal Prince Alfred Hospital, Missenden Road, Camperdown, NSW 2050, Australia
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Sydney Institute for Women, Children and their Families, Sydney Local Health District, Sydney, NSW 2000, Australia
*
Author to whom correspondence should be addressed.
PreBabe Investigator Team also includes: Prof. Vicki Flenady, A/Prof. Beverly Muhlhausler, Dr. Frances Garden, A/Prof. Alison Hayes, Prof. Chris Rissel, Prof. Craig Pennell, Prof. Jonathan Morris, Prof. Dharmintra Pasupathy, Dr. Antonia Shand, Dr. Kathryn Williams.
Academic Editor: Megumi Haruna
Nutrients 2021, 13(9), 3200; https://doi.org/10.3390/nu13093200
Received: 5 August 2021 / Revised: 5 September 2021 / Accepted: 8 September 2021 / Published: 15 September 2021
(This article belongs to the Section Nutrition in Women)
About half of Australian women have a body mass index in the overweight or obese range at the start of pregnancy, with serious consequences including preterm birth, gestational hypertension and diabetes, caesarean section, stillbirth, and childhood obesity. Trials to limit weight gain during pregnancy have had limited success and reducing weight before pregnancy has greater potential to improve outcomes. The PreBabe Pilot study was a randomised controlled pilot trial to assess the feasibility, acceptability and potential weight loss achieved using a commercial online partial meal replacement program, (MR) vs. telephone-based conventional dietary advice, (DA) for pre-conception weight-loss over a 10-week period. Women 18–40 years of age with a BMI ≥ 25 kg/m2 planning pregnancy within the next 6 to 12 months were included in the study. All participants had three clinic visits with a dietitian and one obstetric consultation. In total, 50 women were enrolled in the study between June 2018 and October 2019–26 in MR and 24 in DA. Study retention at the end of 10 week intervention 81% in the MR arm and 75% in the DA arm. In the-intention-to-treat analysis, women using meal replacements lost on average 5.4 ± 3.1% body weight compared to 2.3 ± 4.2% for women receiving conventional advice (p = 0.029). Over 80% of women in the MR arm rated the support received as excellent, compared to 39% in the DA arm (p < 0.001). Women assigned to the MR intervention were more likely to achieve pregnancy within 12 months of the 10 week intervention (57% (12 of 21) women assigned to MR intervention vs. 22% (4 of 18) assigned to the DA group (p = 0.049) became pregnant). The findings suggest that a weight loss intervention using meal replacements in the preconception period was acceptable and may result in greater weight loss than conventional dietary advice alone. View Full-Text
Keywords: preconception; obesity; meal replacement; weight loss; clinical trial preconception; obesity; meal replacement; weight loss; clinical trial
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MDPI and ACS Style

Muirhead, R.; Kizirian, N.; Lal, R.; Black, K.; Prys-Davies, A.; Nassar, N.; Baur, L.; Sainsbury, A.; Sweeting, A.; Markovic, T.; Skilton, M.; Hyett, J.; de Vries, B.; Tarnow-Mordi, W.; Brand-Miller, J.; Gordon, A., on behalf of the PreBabe Investigator Team. A Pilot Randomized Controlled Trial of a Partial Meal Replacement Preconception Weight Loss Program for Women with Overweight and Obesity. Nutrients 2021, 13, 3200. https://doi.org/10.3390/nu13093200

AMA Style

Muirhead R, Kizirian N, Lal R, Black K, Prys-Davies A, Nassar N, Baur L, Sainsbury A, Sweeting A, Markovic T, Skilton M, Hyett J, de Vries B, Tarnow-Mordi W, Brand-Miller J, Gordon A on behalf of the PreBabe Investigator Team. A Pilot Randomized Controlled Trial of a Partial Meal Replacement Preconception Weight Loss Program for Women with Overweight and Obesity. Nutrients. 2021; 13(9):3200. https://doi.org/10.3390/nu13093200

Chicago/Turabian Style

Muirhead, Roslyn, Nathalie Kizirian, Ravin Lal, Kirsten Black, Ann Prys-Davies, Natasha Nassar, Louise Baur, Amanda Sainsbury, Arianne Sweeting, Tania Markovic, Michael Skilton, Jon Hyett, Bradley de Vries, William Tarnow-Mordi, Jennie Brand-Miller, and Adrienne Gordon on behalf of the PreBabe Investigator Team. 2021. "A Pilot Randomized Controlled Trial of a Partial Meal Replacement Preconception Weight Loss Program for Women with Overweight and Obesity" Nutrients 13, no. 9: 3200. https://doi.org/10.3390/nu13093200

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