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Systematic Review

The Effects of Ionizing Radiation on Gut Microbiota, a Systematic Review

1
Department of Nuclear Medicine, Centro Hospitalar Universitário de São João, E.P.E., 4200-319 Porto, Portugal
2
Department of Biomedicine, Faculdade de Medicina da Universidade do Porto, 4200-319 Porto, Portugal
3
i3S, Instituto de Investigação e Inovação em Saúde, Universidade do Porto, 4200-135 Porto, Portugal
4
Department of Pharmaceutical Science, Faculdade de Ciências da Saúde da Universidade Fernando Pessoa, 4249-004 Porto, Portugal
5
Department of Pathology, Centro Hospitalar Universitário do Porto, 4099-001 Porto, Portugal
*
Author to whom correspondence should be addressed.
Academic Editor: Michael Conlon
Nutrients 2021, 13(9), 3025; https://doi.org/10.3390/nu13093025
Received: 6 August 2021 / Revised: 20 August 2021 / Accepted: 26 August 2021 / Published: 29 August 2021
(This article belongs to the Special Issue Diet and Nutrition during Chemotherapy and Radiotherapy)
Background: The human gut microbiota is defined as the microorganisms that collectively inhabit the intestinal tract. Its composition is relatively stable; however, an imbalance can be precipitated by various factors and is known to be associated with various diseases. Humans are daily exposed to ionizing radiation from ambient and medical procedures, and gastrointestinal side effects are not rare. Methods: A systematic search of PubMed, EMBASE, and Cochrane Library databases was conducted. Primary outcomes were changes in composition, richness, and diversity of the gut microbiota after ionizing radiation exposure. Standard methodological procedures expected by Cochrane were used. Results: A total of 2929 nonduplicated records were identified, and based on the inclusion criteria, 11 studies were considered. Studies were heterogeneous, with differences in population and outcomes. Overall, we found evidence for an association between ionizing radiation exposure and dysbiosis: reduction in microbiota diversity and richness, increase in pathogenic bacteria abundance (Proteobacteria and Fusobacteria), and decrease in beneficial bacteria (Faecalibacterium and Bifidobacterium). Conclusions: This review highlights the importance of considering the influence of ionizing radiation exposure on gut microbiota, especially when considering the side effects of abdominal and pelvic radiotherapy. Better knowledge of these effects, with larger population studies, is needed. View Full-Text
Keywords: microbiome; microbiota; intestinal microbiome; gut microbiota; microflora; ionizing radiation; radiotherapy; radiation effects microbiome; microbiota; intestinal microbiome; gut microbiota; microflora; ionizing radiation; radiotherapy; radiation effects
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MDPI and ACS Style

Fernandes, A.; Oliveira, A.; Soares, R.; Barata, P. The Effects of Ionizing Radiation on Gut Microbiota, a Systematic Review. Nutrients 2021, 13, 3025. https://doi.org/10.3390/nu13093025

AMA Style

Fernandes A, Oliveira A, Soares R, Barata P. The Effects of Ionizing Radiation on Gut Microbiota, a Systematic Review. Nutrients. 2021; 13(9):3025. https://doi.org/10.3390/nu13093025

Chicago/Turabian Style

Fernandes, Ana, Ana Oliveira, Raquel Soares, and Pedro Barata. 2021. "The Effects of Ionizing Radiation on Gut Microbiota, a Systematic Review" Nutrients 13, no. 9: 3025. https://doi.org/10.3390/nu13093025

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