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Bovine Colostrum Supplementation Improves Bone Metabolism in an Osteoporosis-Induced Animal Model

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UCIBIO/REQUIMTE, Faculty of Pharmacy, University of Porto, 4050-313 Porto, Portugal
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SALURIS, 28108 Madrid, Spain
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Department of Pharmacology, Pharmacognosy and Botany, Complutense University, 28040 Madrid, Spain
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3B’s Research Group, I3Bs—Research Institute on Biomaterials, Biodegradables and Biomimetics, University of Minho, Headquarters of the European Institute of Excellence on Tissue Engineering and Regenerative Medicine, AvePark, Parque de Ciência e Tecnologia, Zona Industrial da Gandra, 4805-017 Guimarães, Portugal
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ICVS/3B’s—PT Government Associate Laboratory, 4805-017 Guimarães, Portugal
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School of Sports and Exercise Sciences, University of Thessaly, 42100 Trikala, Greece
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Faculty of Education, Health and Wellbeing, University of Wolverhampton, Walsall WS1 3BD, UK
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BME, Biomechanical Solutions, 43150 Karditsa, Greece
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iMed.UL, Faculty of Pharmacy, University of Lisbon, 1649-003 Lisbon, Portugal
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Joaquim Chaves Saúde, 1495-068 Miraflores Algés, Portugal
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Department of Exercise Science, Chatham University, Pittsburgh, PA 15232, USA
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Move-Cor Inc., Pittsburgh, PA 15017, USA
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Author to whom correspondence should be addressed.
Academic Editor: Abderrahmane Ait Kaddour
Nutrients 2021, 13(9), 2981; https://doi.org/10.3390/nu13092981
Received: 22 July 2021 / Revised: 24 August 2021 / Accepted: 24 August 2021 / Published: 27 August 2021
Osteoporosis is characterized by bone loss. The present study aims to investigate the effects of bovine colostrum (BC) on bone metabolism using ovariectomized (OVX) and orchidectomized (ORX) rat models. Twenty-seven-week-old Wistar Han rats were randomly assigned as: (1) placebo control, (2) BC supplementation dose 1 (BC1: 0.5 g/day/OVX, 1 g/day/ORX), (3) BC supplementation dose 2 (BC2: 1 g/day/OVX, 1.5 g/day/ORX) and (4) BC supplementation dose 3 (BC3: 1.5 g/day/OVX, 2 g/day/ORX). Bone microarchitecture, strength, gene expression of VEGFA, FGF2, RANKL, RANK and OPG, and bone resorption/formation markers were assessed after four months of BC supplementation. Compared to the placebo, OVX rats in the BC1 group exhibited significantly higher cortical bone mineral content and trabecular bone mineral content (p < 0.01), while OVX rats in the BC3 group showed significantly higher trabecular bone mineral content (p < 0.05). ORX rats receiving BC dose 2 demonstrated significantly higher levels of trabecular bone mineral content (p < 0.05). Serum osteocalcin in the ORX was pointedly higher in all BC supplementation groups than the placebo (BC1: p < 0.05; BC2, BC3: p < 0.001). Higher doses of BC induced significantly higher relative mRNA expression of OPG, VEGFA, FGF2 and RANKL (p < 0.05). BC supplementation improves bone metabolism of OVX and ORX rats, which might be associated with the activation of the VEGFA, FGF2 and RANKL/RANK/OPG pathways. View Full-Text
Keywords: bovine colostrum; bone; osteoporosis; supplementation bovine colostrum; bone; osteoporosis; supplementation
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MDPI and ACS Style

Kydonaki, E.K.; Freitas, L.; Fonseca, B.M.; Reguengo, H.; Raposo Simón, C.; Bastos, A.R.; Fernandes, E.M.; Canadas, R.F.; Oliveira, J.M.; Correlo, V.M.; Reis, R.L.; Vliora, M.; Gkiata, P.; Koutedakis, Y.; Ntina, G.; Pinto, R.; Carrillo, A.E.; Marques, F.; Amorim, T. Bovine Colostrum Supplementation Improves Bone Metabolism in an Osteoporosis-Induced Animal Model. Nutrients 2021, 13, 2981. https://doi.org/10.3390/nu13092981

AMA Style

Kydonaki EK, Freitas L, Fonseca BM, Reguengo H, Raposo Simón C, Bastos AR, Fernandes EM, Canadas RF, Oliveira JM, Correlo VM, Reis RL, Vliora M, Gkiata P, Koutedakis Y, Ntina G, Pinto R, Carrillo AE, Marques F, Amorim T. Bovine Colostrum Supplementation Improves Bone Metabolism in an Osteoporosis-Induced Animal Model. Nutrients. 2021; 13(9):2981. https://doi.org/10.3390/nu13092981

Chicago/Turabian Style

Kydonaki, Eirini K., Laura Freitas, Bruno M. Fonseca, Henrique Reguengo, Carlos Raposo Simón, Ana R. Bastos, Emanuel M. Fernandes, Raphaël F. Canadas, Joaquim M. Oliveira, Vitor M. Correlo, Rui L. Reis, Maria Vliora, Parakevi Gkiata, Yiannis Koutedakis, Georgia Ntina, Rui Pinto, Andres E. Carrillo, Franklim Marques, and Tânia Amorim. 2021. "Bovine Colostrum Supplementation Improves Bone Metabolism in an Osteoporosis-Induced Animal Model" Nutrients 13, no. 9: 2981. https://doi.org/10.3390/nu13092981

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