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Article

Healthy Breastfeeding Infants Consume Different Quantities of Milk Fat Globule Membrane Lipids

1
School of Molecular Sciences, The University of Western Australia, Crawley, WA 6009, Australia
2
Metabolomics Laboratory, Baker Heart and Diabetes Institute, Melbourne, VIC 3004, Australia
3
Precision Medicine Translational Research Programme and Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 119077, Singapore
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Singapore Lipidomics Incubator, Life Sciences Institute, National University of Singapore, Singapore 119077, Singapore
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School of Population and Global Health, The University of Western Australia, Nedlands, WA 6009, Australia
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Department of Physiology, School of Biomedical Sciences, Faculty of Medicine, Dentistry and Health Sciences, The University of Melbourne, Parkville, VIC 3010, Australia
*
Author to whom correspondence should be addressed.
Academic Editor: Ekhard E. Ziegler
Nutrients 2021, 13(9), 2951; https://doi.org/10.3390/nu13092951
Received: 21 July 2021 / Revised: 16 August 2021 / Accepted: 23 August 2021 / Published: 25 August 2021
(This article belongs to the Section Lipids)
The human milk fat globule membrane (MFGM) contains important lipids for growing infants. Anthropometric measurements, milk samples, and infant milk intake were collected in a cohort of eleven healthy mother–infant dyads during exclusive breastfeeding from birth to six months. One hundred and sixty-six MFGM lipids were analysed using liquid chromatography-mass spectrometry, and the infant intake was calculated. The concentrations and intake were compared and associations between infant intake and growth characteristics explored. The lipid concentrations and infant intake varied widely between mother–infant dyads and between months one and three. The infant intake for many species displayed positive correlations with infant growth, particularly phospholipid species. The high variation in lipid intake is likely an important factor in infant growth, with strong correlations identified between the intake of many MFGM lipids and infant head circumference and weight. This study highlights the need for intake measurements and inclusion in cohort studies to elucidate the role of the human milk lipidome in infant growth and development. View Full-Text
Keywords: human milk; breastmilk; breastfeeding; lipidomics; lactation; fat human milk; breastmilk; breastfeeding; lipidomics; lactation; fat
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MDPI and ACS Style

George, A.D.; Gay, M.C.L.; Selvalatchmanan, J.; Torta, F.; Bendt, A.K.; Wenk, M.R.; Murray, K.; Wlodek, M.E.; Geddes, D.T. Healthy Breastfeeding Infants Consume Different Quantities of Milk Fat Globule Membrane Lipids. Nutrients 2021, 13, 2951. https://doi.org/10.3390/nu13092951

AMA Style

George AD, Gay MCL, Selvalatchmanan J, Torta F, Bendt AK, Wenk MR, Murray K, Wlodek ME, Geddes DT. Healthy Breastfeeding Infants Consume Different Quantities of Milk Fat Globule Membrane Lipids. Nutrients. 2021; 13(9):2951. https://doi.org/10.3390/nu13092951

Chicago/Turabian Style

George, Alexandra D., Melvin C.L. Gay, Jayashree Selvalatchmanan, Federico Torta, Anne K. Bendt, Markus R. Wenk, Kevin Murray, Mary E. Wlodek, and Donna T. Geddes 2021. "Healthy Breastfeeding Infants Consume Different Quantities of Milk Fat Globule Membrane Lipids" Nutrients 13, no. 9: 2951. https://doi.org/10.3390/nu13092951

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