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Supplementation with a Natural Source of Amino Acids, Sil-Q1 (Silk Peptide), Enhances Natural Killer Cell Activity: A Redesigned Clinical Trial with a Reduced Supplementation Dose and Minimized Seasonal Effects in a Larger Population

1
National Leading Research Laboratory of Clinical Nutrigenetics/Nutrigenomics, Department of Food and Nutrition, College of Human Ecology, Yonsei University, Seoul 03722, Korea
2
WORLDWAY Co., Ltd., Sejong-si 30003, Korea
3
Healthcare Claims & Management Inc., Jeonju 54810, Korea
4
Brain Korea 21 PLUS Project, Department of Food and Nutrition, College of Human Ecology, Yonsei University, Seoul 03722, Korea
5
Research Center for Silver Science, Institute of Symbiotic Life-TECH, Yonsei University, Seoul 03722, Korea
*
Author to whom correspondence should be addressed.
These authors contributed equally to this work.
Academic Editor: Lindsay Brown
Nutrients 2021, 13(9), 2930; https://doi.org/10.3390/nu13092930
Received: 2 June 2021 / Revised: 10 August 2021 / Accepted: 19 August 2021 / Published: 24 August 2021
(This article belongs to the Section Nutritional Immunology)
The aim of this study was to re-validate the changes in natural killer (NK) cell cytotoxicity and cytokines related to T cells after Sil-Q1 (SQ; silk peptide) supplementation in a larger pool of Korean adults with minimized daily dose of SQ and controlling seasonal influence compared to the previous study. A total of 130 subjects were randomly assigned (1:1) to consume either 7.5 g of SQ or placebo for 8 weeks. NK cell cytotoxicity and cytokines were measured at T0 (baseline) and T8 (follow-up). Comparing the NK cell cytotoxicity values at T0 and T8 within each group, the cytotoxicity at all effector cell (E) to target cell (T) ratios of 10:1, 5:1, 2.5:1, and 1.25:1 was significantly increased in the SQ group at T8. Additionally, significant differences in the changed value (Δ, subtract baseline values from follow-up values) comparison between the groups at E:T = 10:1, 5:1, and 2.5:1 were found. As a secondary endpoint, the interleukin (IL)-12 level in the SQ group was significantly increased for 8 weeks, and Δ IL-12 in the SQ group was greater than in the placebo group. In conclusion, the present study showed considerable practical implications of SQ supplementation. Thus, SQ is an effective and safe functional food supplement for enhancing immune function. View Full-Text
Keywords: functional food; Sil-Q1; silk peptide; immunostimulatory effect; natural killer cell; cytokines functional food; Sil-Q1; silk peptide; immunostimulatory effect; natural killer cell; cytokines
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MDPI and ACS Style

Cho, J.M.; Yoo, D.; Lee, J.-Y.; Oh, M.-S.; Ha, K.-C.; Baek, H.-I.; Lee, S.-M.; Lee, J.H.; Yoo, H.J. Supplementation with a Natural Source of Amino Acids, Sil-Q1 (Silk Peptide), Enhances Natural Killer Cell Activity: A Redesigned Clinical Trial with a Reduced Supplementation Dose and Minimized Seasonal Effects in a Larger Population. Nutrients 2021, 13, 2930. https://doi.org/10.3390/nu13092930

AMA Style

Cho JM, Yoo D, Lee J-Y, Oh M-S, Ha K-C, Baek H-I, Lee S-M, Lee JH, Yoo HJ. Supplementation with a Natural Source of Amino Acids, Sil-Q1 (Silk Peptide), Enhances Natural Killer Cell Activity: A Redesigned Clinical Trial with a Reduced Supplementation Dose and Minimized Seasonal Effects in a Larger Population. Nutrients. 2021; 13(9):2930. https://doi.org/10.3390/nu13092930

Chicago/Turabian Style

Cho, Jung M., Dokyeong Yoo, Jeong-Yong Lee, Mi-Sun Oh, Ki-Chan Ha, Hyang-Im Baek, Seung-Min Lee, Jong H. Lee, and Hye J. Yoo. 2021. "Supplementation with a Natural Source of Amino Acids, Sil-Q1 (Silk Peptide), Enhances Natural Killer Cell Activity: A Redesigned Clinical Trial with a Reduced Supplementation Dose and Minimized Seasonal Effects in a Larger Population" Nutrients 13, no. 9: 2930. https://doi.org/10.3390/nu13092930

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