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Article

Effect of Dietary Coenzyme Q10 Plus NADH Supplementation on Fatigue Perception and Health-Related Quality of Life in Individuals with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: A Prospective, Randomized, Double-Blind, Placebo-Controlled Trial

1
ME/CFS Research Unit, Division of Rheumatology, Vall d’Hebron Hospital Research Institute, Universitat Autònoma de Barcelona, 08035 Barcelona, Spain
2
Clinical Research Department, Vitae Health Innovation, Montmeló, 08160 Barcelona, Spain
3
Department of Education, Generalitat de Catalunya, Sabadell, 08202 Barcelona, Spain
4
Medical Oncology Clinical Trials Office, Vall d’Hebron Institute of Oncology, Vall d´Hebron University Hospital, Universitat Autònoma de Barcelona, 08035 Barcelona, Spain
*
Author to whom correspondence should be addressed.
These authors have contributed equally to this work.
Academic Editors: Gaetano Santulli and Bruno Trimarco
Nutrients 2021, 13(8), 2658; https://doi.org/10.3390/nu13082658
Received: 14 June 2021 / Revised: 26 July 2021 / Accepted: 29 July 2021 / Published: 30 July 2021
(This article belongs to the Special Issue Dietary Supplements in Cardiovascular and Metabolic Diseases)
Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a complex, multisystem, and profoundly debilitating neuroimmune disease, probably of post-viral multifactorial etiology. Unfortunately, no accurate diagnostic or laboratory tests have been established, nor are any universally effective approved drugs currently available for its treatment. This study aimed to examine whether oral coenzyme Q10 and NADH (reduced form of nicotinamide adenine dinucleotide) co-supplementation could improve perceived fatigue, unrefreshing sleep, and health-related quality of life in ME/CFS patients. A 12-week prospective, randomized, double-blind, placebo-controlled trial was conducted in 207 patients with ME/CFS, who were randomly allocated to one of two groups to receive either 200 mg of CoQ10 and 20 mg of NADH (n = 104) or matching placebo (n = 103) once daily. Endpoints were simultaneously evaluated at baseline, and then reassessed at 4- and 8-week treatment visits and four weeks after treatment cessation, using validated patient-reported outcome measures. A significant reduction in cognitive fatigue perception and overall FIS-40 score (p < 0.001 and p = 0.022, respectively) and an improvement in HRQoL (health-related quality of life (SF-36)) (p < 0.05) from baseline were observed within the experimental group over time. Statistically significant differences were also shown for sleep duration at 4 weeks and habitual sleep efficiency at 8 weeks in follow-up visits from baseline within the experimental group (p = 0.018 and p = 0.038, respectively). Overall, these findings support the use of CoQ10 plus NADH supplementation as a potentially safe therapeutic option for reducing perceived cognitive fatigue and improving the health-related quality of life in ME/CFS patients. Future interventions are needed to corroborate these clinical benefits and also explore the underlying pathomechanisms of CoQ10 and NADH administration in ME/CFS. View Full-Text
Keywords: chronic fatigue syndrome; coenzyme Q10; myalgic encephalomyelitis; mitochondria; nonrestorative sleep; NADH; quality of life chronic fatigue syndrome; coenzyme Q10; myalgic encephalomyelitis; mitochondria; nonrestorative sleep; NADH; quality of life
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MDPI and ACS Style

Castro-Marrero, J.; Segundo, M.J.; Lacasa, M.; Martinez-Martinez, A.; Sentañes, R.S.; Alegre-Martin, J. Effect of Dietary Coenzyme Q10 Plus NADH Supplementation on Fatigue Perception and Health-Related Quality of Life in Individuals with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: A Prospective, Randomized, Double-Blind, Placebo-Controlled Trial. Nutrients 2021, 13, 2658. https://doi.org/10.3390/nu13082658

AMA Style

Castro-Marrero J, Segundo MJ, Lacasa M, Martinez-Martinez A, Sentañes RS, Alegre-Martin J. Effect of Dietary Coenzyme Q10 Plus NADH Supplementation on Fatigue Perception and Health-Related Quality of Life in Individuals with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: A Prospective, Randomized, Double-Blind, Placebo-Controlled Trial. Nutrients. 2021; 13(8):2658. https://doi.org/10.3390/nu13082658

Chicago/Turabian Style

Castro-Marrero, Jesús, Maria J. Segundo, Marcos Lacasa, Alba Martinez-Martinez, Ramon S. Sentañes, and Jose Alegre-Martin. 2021. "Effect of Dietary Coenzyme Q10 Plus NADH Supplementation on Fatigue Perception and Health-Related Quality of Life in Individuals with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: A Prospective, Randomized, Double-Blind, Placebo-Controlled Trial" Nutrients 13, no. 8: 2658. https://doi.org/10.3390/nu13082658

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