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Article

The Metabolomic-Gut-Clinical Axis of Mankai Plant-Derived Dietary Polyphenols

1
Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva 8410501, Israel
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Department of Food Quality and Nutrition, Fondazione Edmund Mach, Research and Innovation Centre, Via E. Mach, 1, San Michele all’Adige, 38098 Trento, Italy
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Department of Molecular Systems Biology, Helmholtz Centre for Environmental Research GmbH, 04318 Leipzig, Germany
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Biodesign Center for Health through Microbiomes, School of Sustainable Engineering and the Built Environment, Arizona State University, Tempe, AZ 85281, USA
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Department of Plant and Environmental Sciences, Weizmann Institute of Science, Rehovot 7610001, Israel
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Biodesign Swette Center for Environmental Biotechnology, Arizona State University, Tempe, AZ 85287, USA
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Faculty of Science and Technology, Universitätsplatz 5-Piazza Università, 39100 Bozen-Bolzano, Italy
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Institute for Laboratory Medicine, University of Leipzig Medical Center, 04103 Leipzig, Germany
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Research and Development Department, Hinoman Ltd., Rishon Lezion 7546302, Israel
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Department of Nutrition, Harvard School of Public Health, Boston, MA 02115, USA
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Department of Epidemiology, Harvard School of Public Health, Boston, MA 02115, USA
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Channing Division of Network Medicine, Department of Medicine, Brigham and Women’s Hospital and Harvard Medical School, Boston, MA 02118, USA
*
Author to whom correspondence should be addressed.
Academic Editor: Francesca Giampieri
Nutrients 2021, 13(6), 1866; https://doi.org/10.3390/nu13061866
Received: 10 May 2021 / Revised: 26 May 2021 / Accepted: 27 May 2021 / Published: 30 May 2021
(This article belongs to the Special Issue The Efficacy and Role of Dietary Polyphenols)
Background: Polyphenols are secondary metabolites produced by plants to defend themselves from environmental stressors. We explored the effect of Wolffia globosa ‘Mankai’, a novel cultivated strain of a polyphenol-rich aquatic plant, on the metabolomic-gut clinical axis in vitro, in-vivo and in a clinical trial. Methods: We used mass-spectrometry-based metabolomics methods from three laboratories to detect Mankai phenolic metabolites and examined predicted functional pathways in a Mankai artificial-gut bioreactor. Plasma and urine polyphenols were assessed among the 294 DIRECT-PLUS 18-month trial participants, comparing the effect of a polyphenol-rich green-Mediterranean diet (+1240 mg/polyphenols/day, provided by Mankai, green tea and walnuts) to a walnuts-enriched (+440 mg/polyphenols/day) Mediterranean diet and a healthy controlled diet. Results: Approximately 200 different phenolic compounds were specifically detected in the Mankai plant. The Mankai-supplemented bioreactor artificial gut displayed a significantly higher relative-abundance of 16S-rRNA bacterial gene sequences encoding for enzymes involved in phenolic compound degradation. In humans, several Mankai-related plasma and urine polyphenols were differentially elevated in the green Mediterranean group compared with the other groups (p < 0.05) after six and 18 months of intervention (e.g., urine hydroxy-phenyl-acetic-acid and urolithin-A; plasma Naringenin and 2,5-diOH-benzoic-acid). Specific polyphenols, such as urolithin-A and 4-ethylphenol, were directly involved with clinical weight-related changes. Conclusions: The Mankai new plant is rich in various unique potent polyphenols, potentially affecting the metabolomic-gut-clinical axis. View Full-Text
Keywords: Wolffia globosa; polyphenols; flavonoids; plant-based nutrition; weight loss; mediterranean diet Wolffia globosa; polyphenols; flavonoids; plant-based nutrition; weight loss; mediterranean diet
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MDPI and ACS Style

Yaskolka Meir, A.; Tuohy, K.; von Bergen, M.; Krajmalnik-Brown, R.; Heinig, U.; Zelicha, H.; Tsaban, G.; Rinott, E.; Kaplan, A.; Aharoni, A.; Zeibich, L.; Chang, D.; Dirks, B.; Diotallevi, C.; Arapitsas, P.; Vrhovsek, U.; Ceglarek, U.; Haange, S.-B.; Rolle-Kampczyk, U.; Engelmann, B.; Lapidot, M.; Colt, M.; Sun, Q.; Shai, I. The Metabolomic-Gut-Clinical Axis of Mankai Plant-Derived Dietary Polyphenols. Nutrients 2021, 13, 1866. https://doi.org/10.3390/nu13061866

AMA Style

Yaskolka Meir A, Tuohy K, von Bergen M, Krajmalnik-Brown R, Heinig U, Zelicha H, Tsaban G, Rinott E, Kaplan A, Aharoni A, Zeibich L, Chang D, Dirks B, Diotallevi C, Arapitsas P, Vrhovsek U, Ceglarek U, Haange S-B, Rolle-Kampczyk U, Engelmann B, Lapidot M, Colt M, Sun Q, Shai I. The Metabolomic-Gut-Clinical Axis of Mankai Plant-Derived Dietary Polyphenols. Nutrients. 2021; 13(6):1866. https://doi.org/10.3390/nu13061866

Chicago/Turabian Style

Yaskolka Meir, Anat; Tuohy, Kieran; von Bergen, Martin; Krajmalnik-Brown, Rosa; Heinig, Uwe; Zelicha, Hila; Tsaban, Gal; Rinott, Ehud; Kaplan, Alon; Aharoni, Asaph; Zeibich, Lydia; Chang, Debbie; Dirks, Blake; Diotallevi, Camilla; Arapitsas, Panagiotis; Vrhovsek, Urska; Ceglarek, Uta; Haange, Sven-Bastiaan; Rolle-Kampczyk, Ulrike; Engelmann, Beatrice; Lapidot, Miri; Colt, Monica; Sun, Qi; Shai, Iris. 2021. "The Metabolomic-Gut-Clinical Axis of Mankai Plant-Derived Dietary Polyphenols" Nutrients 13, no. 6: 1866. https://doi.org/10.3390/nu13061866

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