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Article

Can Cranberry Juice Protect against Rotenone-Induced Toxicity in Rats?

1
Department of Toxicology, Poznan University of Medical Sciences, Dojazd 30, 60-631 Poznań, Poland
2
Department of Pharmacognosy, Poznan University of Medical Sciences, Święcickiego 4, 60-781 Poznań, Poland
3
Department of Pharmaceutical Biochemistry, Poznan University of Medical Sciences, ul. Święcickiego 4, 60-781 Poznań, Poland
*
Author to whom correspondence should be addressed.
Academic Editor: Dario Donno
Nutrients 2021, 13(4), 1050; https://doi.org/10.3390/nu13041050
Received: 18 February 2021 / Revised: 19 March 2021 / Accepted: 20 March 2021 / Published: 24 March 2021
(This article belongs to the Collection The Efficacy and Role of Dietary Polyphenols)
The high polyphenols content of cranberry accounts for its strong antioxidant activity underlying the beneficial health effects of this fruit. Rotenone (ROT) is a specific inhibitor of mitochondrial complex I in the brain which leads to the generation of oxidative stress. To date, there are few data indicating that toxicity of ROT is not limited to the brain but can also affect other tissues. We aimed to examine whether ROT-induced oxidative stress could be counteracted by cranberry juice not only in the brain but also in the liver and kidney. Wistar rats were given the combined treatment with ROT and cranberry juice (CJ) for 35 days. Parameters of antioxidant status were determined in the organs. ROT enhanced lipid peroxidation solely in the brain. The increase in the DNA damage was noticed in all organs examined and in leukocytes. The beneficial effect of CJ on these parameters appeared only in the brain. Additionally, CJ decreased the activity of serum hepatic enzymes. The effect of CJ on antioxidant enzymes was not consistent, however, in some organs, CJ reversed changes evoked by ROT. Summing up, ROT can cause oxidative damage not only in the brain but also in other organs. CJ demonstrated a protective effect against ROT-induced toxicity. View Full-Text
Keywords: oxidative stress; liver; kidney; brain; serum; polyphenols; HPLC analysis oxidative stress; liver; kidney; brain; serum; polyphenols; HPLC analysis
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MDPI and ACS Style

Kurpik, M.; Zalewski, P.; Kujawska, M.; Ewertowska, M.; Ignatowicz, E.; Cielecka-Piontek, J.; Jodynis-Liebert, J. Can Cranberry Juice Protect against Rotenone-Induced Toxicity in Rats? Nutrients 2021, 13, 1050. https://doi.org/10.3390/nu13041050

AMA Style

Kurpik M, Zalewski P, Kujawska M, Ewertowska M, Ignatowicz E, Cielecka-Piontek J, Jodynis-Liebert J. Can Cranberry Juice Protect against Rotenone-Induced Toxicity in Rats? Nutrients. 2021; 13(4):1050. https://doi.org/10.3390/nu13041050

Chicago/Turabian Style

Kurpik, Monika, Przemysław Zalewski, Małgorzata Kujawska, Małgorzata Ewertowska, Ewa Ignatowicz, Judyta Cielecka-Piontek, and Jadwiga Jodynis-Liebert. 2021. "Can Cranberry Juice Protect against Rotenone-Induced Toxicity in Rats?" Nutrients 13, no. 4: 1050. https://doi.org/10.3390/nu13041050

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