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Article

Probiotic and Functional Properties of Limosilactobacillus reuteri INIA P572

1
Centro de Investigaciones Biomédicas en Red–Enfermedades Hepáticas y Digestivas (CIBER-EHD), Department of Pharmacology, Center for Biomedical Research (CIBM), University of Granada, Avenida del Conocimiento s/n, 18100 Granada, Spain
2
Instituto de Investigación Biosanitaria de Granada (ibs.GRANADA), 18012 Granada, Spain
3
Departamento Tecnología de Alimentos, INIA-CSIC, Carretera de La Coruña Km 7, 28040 Madrid, Spain
4
Gut Microbes and Health Institute Strategic Programme, Quadram Institute Bioscience, Norwich NR4-7UZ, UK
5
Centro para la Calidad de los Alimentos, INIA-CISC, c/José Tudela s/n, 42004 Soria, Spain
*
Author to whom correspondence should be addressed.
These authors contributed equally to this work.
These authors contributed equally to the supervision of this work.
Academic Editor: Bengt Jeppsson
Nutrients 2021, 13(6), 1860; https://doi.org/10.3390/nu13061860
Received: 27 April 2021 / Revised: 19 May 2021 / Accepted: 24 May 2021 / Published: 29 May 2021
(This article belongs to the Section Prebiotics and Probiotics)
Limosilactobacillus reuteri INIA P572 is a strain able to produce the antimicrobial compound reuterin in dairy products, exhibiting a protective effect against some food-borne pathogens. In this study, we investigated some probiotic properties of this strain such as resistance to gastrointestinal passage or to colonic conditions, reuterin production in a colonic environment, and immunomodulatory activity, using different in vitro and in vivo models. The results showed a high resistance of this strain to gastrointestinal conditions, as well as capacity to grow and produce reuterin in a human colonic model. Although the in vitro assays using the RAW 264.7 macrophage cell line did not demonstrate direct immunomodulatory properties, the in vivo assays using a Dextran Sulphate Sodium (DSS)-induced colitic mice model showed clear immunomodulatory and protective effects of this strain. View Full-Text
Keywords: Limosilactobacillus reuteri; probiotic; colonic model; DSS-induced colitic model; immunomodulation; reuterin; protective effect Limosilactobacillus reuteri; probiotic; colonic model; DSS-induced colitic model; immunomodulation; reuterin; protective effect
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MDPI and ACS Style

Diez-Echave, P.; Martín-Cabrejas, I.; Garrido-Mesa, J.; Langa, S.; Vezza, T.; Landete, J.M.; Hidalgo-García, L.; Algieri, F.; Mayer, M.J.; Narbad, A.; García-Lafuente, A.; Medina, M.; Rodríguez-Nogales, A.; Rodríguez-Cabezas, M.E.; Gálvez, J.; Arqués, J.L. Probiotic and Functional Properties of Limosilactobacillus reuteri INIA P572. Nutrients 2021, 13, 1860. https://doi.org/10.3390/nu13061860

AMA Style

Diez-Echave P, Martín-Cabrejas I, Garrido-Mesa J, Langa S, Vezza T, Landete JM, Hidalgo-García L, Algieri F, Mayer MJ, Narbad A, García-Lafuente A, Medina M, Rodríguez-Nogales A, Rodríguez-Cabezas ME, Gálvez J, Arqués JL. Probiotic and Functional Properties of Limosilactobacillus reuteri INIA P572. Nutrients. 2021; 13(6):1860. https://doi.org/10.3390/nu13061860

Chicago/Turabian Style

Diez-Echave, Patricia, Izaskun Martín-Cabrejas, José Garrido-Mesa, Susana Langa, Teresa Vezza, José M. Landete, Laura Hidalgo-García, Francesca Algieri, Melinda J. Mayer, Arjan Narbad, Ana García-Lafuente, Margarita Medina, Alba Rodríguez-Nogales, María Elena Rodríguez-Cabezas, Julio Gálvez, and Juan L. Arqués. 2021. "Probiotic and Functional Properties of Limosilactobacillus reuteri INIA P572" Nutrients 13, no. 6: 1860. https://doi.org/10.3390/nu13061860

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