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Emergent Drug and Nutrition Interactions in COVID-19: A Comprehensive Narrative Review

Department of Nutrition and Dietetics, Faculty of Health Sciences, Gazi University, Emek, Ankara 06490, Turkey
Department of Agricultural Sciences, University of Naples Federico II, 80055 Naples, Italy
Authors to whom correspondence should be addressed.
Academic Editors: Carlo Agostoni and Gregorio Paolo Milani
Nutrients 2021, 13(5), 1550;
Received: 19 March 2021 / Revised: 26 April 2021 / Accepted: 28 April 2021 / Published: 4 May 2021
(This article belongs to the Special Issue Nutrition within and beyond Corona Virus)
Coronaviruses are a large family of viruses that are known to cause respiratory tract infections ranging from colds to more severe diseases, such as Middle East Respiratory Syndrome (MERS) and the Severe Acute Respiratory Syndrome (SARS). New Coronavirus Disease 2019 (COVID-19), which led to deaths as well as social and economic disruptions, is an ongoing worldwide pandemic caused by Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2). Currently, there is no approved treatment for COVID-19. Hence, only supportive care has been approved by the World Health Organization (WHO) for now. Pharmacological agents used for the adjunctive treatment of COVID-19 following the current literature and clinical experiences include antiviral, anti-inflammatory, and anti-malaria drugs, and other traditional or untraditional treatments. However, it has been reported that the use of these drugs may have some negative effects and comorbidities. Moreover, the current data have indicated that the risk of drug-drug interactions may also be high in polypharmacy cases, especially in elderly people, some comorbidity situations, and intensive care unit (ICU) patients. It is highly possible that these situations can not only increase the risk of drug-drug interactions but also increase the risk of food/nutrition-drug interactions and affect the nutritional status. However, this issue has not yet been entirely discussed in the literature. In this review, current information on the possible mechanisms as well as pharmacokinetic and pharmacodynamic effects of some pharmacological agents used in the treatment of COVID-19 and/or their secondary interactions with nutrition were evaluated and some future directions were given. View Full-Text
Keywords: COVID-19; drug; nutrition interaction COVID-19; drug; nutrition interaction
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MDPI and ACS Style

Ağagündüz, D.; Çelik, M.N.; Çıtar Dazıroğlu, M.E.; Capasso, R. Emergent Drug and Nutrition Interactions in COVID-19: A Comprehensive Narrative Review. Nutrients 2021, 13, 1550.

AMA Style

Ağagündüz D, Çelik MN, Çıtar Dazıroğlu ME, Capasso R. Emergent Drug and Nutrition Interactions in COVID-19: A Comprehensive Narrative Review. Nutrients. 2021; 13(5):1550.

Chicago/Turabian Style

Ağagündüz, Duygu; Çelik, Menşure N.; Çıtar Dazıroğlu, Merve E.; Capasso, Raffaele. 2021. "Emergent Drug and Nutrition Interactions in COVID-19: A Comprehensive Narrative Review" Nutrients 13, no. 5: 1550.

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