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Article

Effect of Oat β-Glucan on Affective and Physical Feeling States in Healthy Adults: Evidence for Reduced Headache, Fatigue, Anxiety and Limb/Joint Pains

1
Formerly GI Labs, INQUIS Clinical Research, Ltd., Toronto, ON M5C 2N8, Canada
2
Quaker Oats Center of Excellence, PepsiCo R&D Nutrition, Barrington, IL 60010, USA
*
Author to whom correspondence should be addressed.
Current address: DSM Nutritional Products, North America Nutrition Science and Advocacy, Parsippany, NJ 07054, USA.
Academic Editors: Seiichiro Aoe, Tatsuya Morita and Naohito Ohno
Nutrients 2021, 13(5), 1534; https://doi.org/10.3390/nu13051534
Received: 12 March 2021 / Revised: 25 April 2021 / Accepted: 29 April 2021 / Published: 1 May 2021
(This article belongs to the Special Issue Beta-Glucan in Foods and Health Benefits)
The gastrointestinal (GI) side-effects of dietary fibers are recognized, but less is known about their effects on non-GI symptoms. We assessed non-GI symptoms in a trial of the LDL-cholesterol lowering effect of oat β-glucan (OBG). Participants (n = 207) with borderline high LDL-cholesterol were randomized to an OBG (1 g OBG, n = 104, n = 96 analyzed) or Control (n = 103, n = 95 analyzed) beverage 3-times daily for 4 weeks. At screening, baseline, 2 weeks and 4 weeks participants rated the severity of 16 non-GI symptoms as none, mild, moderate or severe. The occurrence and severity (more or less severe than pre-treatment) were compared using chi-squared and Fisher’s exact test, respectively. During OBG treatment, the occurrence of exhaustion and fatigue decreased versus baseline (p < 0.05). The severity of headache (2 weeks, p = 0.032), anxiety (2 weeks p = 0.059) and feeling cold (4 weeks, p = 0.040) were less on OBG than Control. The severity of fatigue and hot flashes at 4 weeks, limb/joint pain at 2 weeks and difficulty concentrating at both times decreased on OBG versus baseline. High serum c-reactive-protein and changes in c-reactive-protein, oxidized-LDL, and GI-symptom severity were associated with the occurrence and severity of several non-GI symptoms. These data provide preliminary, hypothesis-generating evidence that OBG may reduce several non-GI symptoms in healthy adults. View Full-Text
Keywords: randomized clinical trial; humans; symptoms; gastrointestinal tract; musculo-skeletal system; oats; oatmeal; dietary fiber; beta-glucan randomized clinical trial; humans; symptoms; gastrointestinal tract; musculo-skeletal system; oats; oatmeal; dietary fiber; beta-glucan
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MDPI and ACS Style

Wolever, T.M.S.; Rahn, M.; Dioum, E.H.; Jenkins, A.L.; Ezatagha, A.; Campbell, J.E.; Chu, Y. Effect of Oat β-Glucan on Affective and Physical Feeling States in Healthy Adults: Evidence for Reduced Headache, Fatigue, Anxiety and Limb/Joint Pains. Nutrients 2021, 13, 1534. https://doi.org/10.3390/nu13051534

AMA Style

Wolever TMS, Rahn M, Dioum EH, Jenkins AL, Ezatagha A, Campbell JE, Chu Y. Effect of Oat β-Glucan on Affective and Physical Feeling States in Healthy Adults: Evidence for Reduced Headache, Fatigue, Anxiety and Limb/Joint Pains. Nutrients. 2021; 13(5):1534. https://doi.org/10.3390/nu13051534

Chicago/Turabian Style

Wolever, Thomas M.S., Maike Rahn, El H. Dioum, Alexandra L. Jenkins, Adish Ezatagha, Janice E. Campbell, and YiFang Chu. 2021. "Effect of Oat β-Glucan on Affective and Physical Feeling States in Healthy Adults: Evidence for Reduced Headache, Fatigue, Anxiety and Limb/Joint Pains" Nutrients 13, no. 5: 1534. https://doi.org/10.3390/nu13051534

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