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Article

Mixed Tree Nut Snacks Compared to Refined Carbohydrate Snacks Resulted in Weight Loss and Increased Satiety during Both Weight Loss and Weight Maintenance: A 24-Week Randomized Controlled Trial

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Center for Human Nutrition, Department of Medicine, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA 90095, USA
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College of Animal Science and Technology, Hunan Agricultural University, Changsha 410128, China
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Center of Yangtze River Delta Region Green Pharmaceuticals, College of Pharmaceutical Science & Collaborative Innovation, Zhejiang University of Technology, Hangzhou 310014, China
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Key Laboratory of Health Cultivation of the Ministry of Education, Beijing University of Chinese Medicine, Beijing 100029, China
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Department of Statistics Core, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA 90095, USA
*
Author to whom correspondence should be addressed.
Academic Editor: Peter Pribis
Nutrients 2021, 13(5), 1512; https://doi.org/10.3390/nu13051512
Received: 11 March 2021 / Revised: 19 April 2021 / Accepted: 23 April 2021 / Published: 30 April 2021
(This article belongs to the Section Phytochemicals and Human Health)
Mixed tree nuts (MTNs) are an excellent source of protein and healthy fat contributing to satiety. However, their relatively high caloric content might not be beneficial in a weight loss diet. The present study was designed to test whether including MTNs in a weight loss and maintenance program interferes with weight management compared to a refined carbohydrate pretzel snack (PS). We performed a randomized, controlled, two-arm study in 95 overweight individuals consuming 1.5 oz of MTNs or PS daily as part of a hypocaloric weight loss diet (−500 kcal) over 12 weeks followed by an isocaloric weight maintenance program for 12 weeks. Participants in both groups experienced significant weight loss (12 weeks: −1.6 and −1.9 and 24 weeks: −1.5 and −1.4 kg) compared to baseline in the MTN and PS groups, respectively. However, there was no difference in weight loss and other outcome parameters between the MTN and PS groups. The MTN group showed a significant increase in satiety at 24 weeks. Both groups had a decrease in diastolic blood pressure at 12 weeks. Participants in the MTN group showed significant decreases in heart rate at 4, 12, and 24 weeks. Plasma oleic acid was significantly increased at 12 and 24 weeks in the MTN group but only at 12 weeks in the PS group. Plasma MCP-1 was decreased significantly in the MTN group at 4 weeks. In summary, participants in both groups lost weight, but only the MTN intervention increased satiety at 24 weeks, enhanced retention, decreased heart rate, and increased serum oleic acid at 24 weeks. View Full-Text
Keywords: mixed tree nuts; weight loss; weight maintenance; human study; inflammatory markers mixed tree nuts; weight loss; weight maintenance; human study; inflammatory markers
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MDPI and ACS Style

Wang, J.; Wang, S.; Henning, S.M.; Qin, T.; Pan, Y.; Yang, J.; Huang, J.; Tseng, C.-H.; Heber, D.; Li, Z. Mixed Tree Nut Snacks Compared to Refined Carbohydrate Snacks Resulted in Weight Loss and Increased Satiety during Both Weight Loss and Weight Maintenance: A 24-Week Randomized Controlled Trial. Nutrients 2021, 13, 1512. https://doi.org/10.3390/nu13051512

AMA Style

Wang J, Wang S, Henning SM, Qin T, Pan Y, Yang J, Huang J, Tseng C-H, Heber D, Li Z. Mixed Tree Nut Snacks Compared to Refined Carbohydrate Snacks Resulted in Weight Loss and Increased Satiety during Both Weight Loss and Weight Maintenance: A 24-Week Randomized Controlled Trial. Nutrients. 2021; 13(5):1512. https://doi.org/10.3390/nu13051512

Chicago/Turabian Style

Wang, Jing, Sijia Wang, Susanne M. Henning, Tianyu Qin, Yajing Pan, Jieping Yang, Jianjun Huang, Chi-Hong Tseng, David Heber, and Zhaoping Li. 2021. "Mixed Tree Nut Snacks Compared to Refined Carbohydrate Snacks Resulted in Weight Loss and Increased Satiety during Both Weight Loss and Weight Maintenance: A 24-Week Randomized Controlled Trial" Nutrients 13, no. 5: 1512. https://doi.org/10.3390/nu13051512

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