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Formyl Peptide Receptor (FPR)1 Modulation by Resveratrol in an LPS-Induced Neuroinflammatory Animal Model

Department of Biosciences, Biotechnologies and Biopharmaceutics, University of Bari, I-70125 Bari, Italy
Department of Clinical and Experimental Medicine, University of Foggia, I-71100 Foggia, Italy
Nuclear Medicine Department, SS. Annunziata Hospital, I-74100 Taranto, Italy
Department of Biological and Environmental Sciences and Technologies, Section of Human Anatomy, University of Salento, I-73100 Lecce, Italy
Author to whom correspondence should be addressed.
These authors contributed equally to this work.
Academic Editor: Filippo M. Santorelli
Nutrients 2021, 13(5), 1418;
Received: 26 March 2021 / Revised: 17 April 2021 / Accepted: 21 April 2021 / Published: 23 April 2021
(This article belongs to the Special Issue Nutrition, Immunity, and Neurological Diseases)
Among therapeutic approaches that have been investigated, targeting of receptors implicated in managing neuroinflammation has been described. One such family of receptors comprises the formyl peptide receptors (FPRs) whose ligands could play a role in host defense. The murine FPR gene family includes at least six members while in humans there are only three. The two most important members are the Fpr1 and Fpr2. Fpr1encodes murine FPR1, which is considered the murine orthologue of human FPR. Resveratrol, a non-flavonoid polyphenol rich in red wine and grapes, apart from its beneficial health effects and anti-inflammatory properties, has been reported to reduce neuroinflammation in different neurodegenerative disease models. Resveratrol anti-inflammatory responses involve the activation of the protein deacetylase sirtuin 1 (SIRT1) gene. In this work we have investigated in an LPS-based murine model of neuroinflammation the role of FPR1, examining not only if this receptor undergoes a reduction of its expression during neuroinflammation, but also whether treatment with resveratrol was able to modulate its expression leading to an amelioration of neuroinflammatory picture in a murine model of neuroinflammation. Results of this work showed that FPR1 together with SIRT1 resulted upregulated by resveratrol treatment and that this increase is associated with an amelioration of the neuroinflammatory picture, as demonstrated by the induction of IL-10 and IL1-RA expression and the downregulation of proinflammatory mediators, such as TNF-α and IL-1β. The expression and the modulation of FPR1 by resveratrol may be evaluated in order to propose a novel anti-inflammatory and pro-resolving therapeutic approach for the reduction of the detrimental effects associated with neuro-inflammation based neurodegenerative diseases and also as a promising strategy to promote human health by a diet rich in antioxidative bioactive compounds. View Full-Text
Keywords: FPR; resveratrol; nutrition; microglia; neuroinflammation FPR; resveratrol; nutrition; microglia; neuroinflammation
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MDPI and ACS Style

Calvello, R.; Cianciulli, A.; Porro, C.; Moda, P.; De Nuccio, F.; Nicolardi, G.; Giannotti, L.; Panaro, M.A.; Lofrumento, D.D. Formyl Peptide Receptor (FPR)1 Modulation by Resveratrol in an LPS-Induced Neuroinflammatory Animal Model. Nutrients 2021, 13, 1418.

AMA Style

Calvello R, Cianciulli A, Porro C, Moda P, De Nuccio F, Nicolardi G, Giannotti L, Panaro MA, Lofrumento DD. Formyl Peptide Receptor (FPR)1 Modulation by Resveratrol in an LPS-Induced Neuroinflammatory Animal Model. Nutrients. 2021; 13(5):1418.

Chicago/Turabian Style

Calvello, Rosa, Antonia Cianciulli, Chiara Porro, Piergianni Moda, Francesco De Nuccio, Giuseppe Nicolardi, Laura Giannotti, Maria Antonietta Panaro, and Dario Domenico Lofrumento. 2021. "Formyl Peptide Receptor (FPR)1 Modulation by Resveratrol in an LPS-Induced Neuroinflammatory Animal Model" Nutrients 13, no. 5: 1418.

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