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A Combination of Lactoplantibacillus plantarum Strains CECT7527, CECT7528, and CECT7529 Plus Monacolin K Reduces Blood Cholesterol: Results from a Randomized, Double-Blind, Placebo-Controlled Study

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Department of Nursing, Merida University Center, University of Extremadura, Av. Santa Teresa de Jornet 38, 06800 Mérida, Spain
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Department of Nursing, Faculty of Medicine and Health Sciences, University of Extremadura, Av. Elvas s/n, 06006 Badajoz, Spain
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AB-BIOTICS SA, ESADE Creapolis 3B011, Av. Torre Blanca 57, 08172 Barcelona, Spain
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Authors to whom correspondence should be addressed.
Academic Editor: Stefano Guandalini
Nutrients 2021, 13(4), 1206; https://doi.org/10.3390/nu13041206
Received: 7 March 2021 / Revised: 2 April 2021 / Accepted: 3 April 2021 / Published: 6 April 2021
(This article belongs to the Section Prebiotics and Probiotics)
Background: Dietary supplements have been proposed to help manage blood cholesterol, including red yeast rice (RYR) extracts, plant sterols and stanols, beta-glucans, and some probiotics. This study was conducted to evaluate the efficacy of RYR (containing 10 mg of monacolin K) combined with 109 CFU of three Lactoplantibacillus plantarum strains (CECT7527, CECT7528, and CECT7529). Methods: A 12-week randomized, double-blinded, placebo-controlled clinical trial was conducted. In total, 39 adult patients were enrolled, having total cholesterol (TC) ≥200 mg/dL, and being statin-naïve or having recently stopped statin treatment because of intolerance. Active product or placebo were taken once daily, and subjects were evaluated at baseline, 6, and 12 weeks. Results: Study groups were comparable at baseline, except for history of recent hypercholesterolemia treatment (81% in active vs. 22% in placebo). Changes in LDL cholesterol and TC became significant compared to placebo (mean difference between groups and standard error of the mean = 23.6 ± 1.5 mg/dL, p = 0.023 and 31.4 ± 1.9 mg/dL, p = 0.011, respectively) upon adjusting for the baseline imbalance in hypercholesterolemia treatment. No adverse effects were noted during the study. Conclusion: This combination of 10 mg of monacolin K and L. plantarum strains was well tolerated and achieved a statistically significant greater reduction in LDL-C and TC in the intervention group compared to the placebo, once adjusting for recent history of hypercholesterolemia treatment. View Full-Text
Keywords: probiotic bacteria; monacolin K; Lactoplantibacillus plantarum; LDL-cholesterol; bile-salt hydrolases; statins probiotic bacteria; monacolin K; Lactoplantibacillus plantarum; LDL-cholesterol; bile-salt hydrolases; statins
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MDPI and ACS Style

Guerrero-Bonmatty, R.; Gil-Fernández, G.; Rodríguez-Velasco, F.J.; Espadaler-Mazo, J. A Combination of Lactoplantibacillus plantarum Strains CECT7527, CECT7528, and CECT7529 Plus Monacolin K Reduces Blood Cholesterol: Results from a Randomized, Double-Blind, Placebo-Controlled Study. Nutrients 2021, 13, 1206. https://doi.org/10.3390/nu13041206

AMA Style

Guerrero-Bonmatty R, Gil-Fernández G, Rodríguez-Velasco FJ, Espadaler-Mazo J. A Combination of Lactoplantibacillus plantarum Strains CECT7527, CECT7528, and CECT7529 Plus Monacolin K Reduces Blood Cholesterol: Results from a Randomized, Double-Blind, Placebo-Controlled Study. Nutrients. 2021; 13(4):1206. https://doi.org/10.3390/nu13041206

Chicago/Turabian Style

Guerrero-Bonmatty, Rafael, Guadalupe Gil-Fernández, Francisco J. Rodríguez-Velasco, and Jordi Espadaler-Mazo. 2021. "A Combination of Lactoplantibacillus plantarum Strains CECT7527, CECT7528, and CECT7529 Plus Monacolin K Reduces Blood Cholesterol: Results from a Randomized, Double-Blind, Placebo-Controlled Study" Nutrients 13, no. 4: 1206. https://doi.org/10.3390/nu13041206

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