Next Article in Journal
Vegetarian Diet Is Associated with Lower Risk of Depression in Taiwan
Next Article in Special Issue
The Effectiveness of Probiotic Lactobacillus rhamnosus and Lactobacillus casei Strains in Children with Atopic Dermatitis and Cow’s Milk Protein Allergy: A Multicenter, Randomized, Double Blind, Placebo Controlled Study
Previous Article in Journal
i-Rebound after Stroke-Eat for Health: Mediterranean Dietary Intervention Co-Design Using an Integrated Knowledge Translation Approach and the TIDieR Checklist
Previous Article in Special Issue
Effectiveness of Personalized Low Salicylate Diet in the Management of Salicylates Hypersensitive Patients: Interventional Study
Article

Assessment of Inflammatory Markers in Children with Cow’s Milk Allergy Treated with a Milk-Free Diet

1
Department of Screening Tests and Metabolic Diagnostics, Institute of Mother and Child, Kasprzaka 17A, 01-211 Warsaw, Poland
2
Department of Nutrition, Institute of Mother and Child, Kasprzaka 17A, 01-211 Warsaw, Poland
*
Author to whom correspondence should be addressed.
Academic Editor: Margarida Castell Escuer
Nutrients 2021, 13(4), 1057; https://doi.org/10.3390/nu13041057
Received: 8 February 2021 / Revised: 19 March 2021 / Accepted: 21 March 2021 / Published: 24 March 2021
(This article belongs to the Special Issue Food Sensitivity: Causes and Management)
Background: The aim of the study was to establish whether the use of a strict milk-free diet in children with cow’s milk allergy, resulting in the resolution of clinical symptoms of the disease, also extinguishes the inflammatory reaction induced by the allergy. Methods: We examined 64 children (aged 3–6 years) with a diagnosed cow’s milk allergy who had been treated with an elimination diet for at least six months and showed remission of the disease’s clinical symptoms as a result of the treatment. The control group consisted of 30 healthy children of the same age following an unrestricted age-appropriate diet. Concentrations of cytokines, calprotectin, and adipokines (leptin, resistin, chemerin, neutrophilic lipocalin associated with gelatinase—NGAL) were determined in the serum samples obtained from the studied children by immunoenzymatic assays. Results: Patients with CMA had significantly higher median values of serum IL-6, TNF-α, resistin, chemerin and NGAL in comparison to the healthy children (p < 0.05, p < 0.001, p < 0.05, p < 0.01, p < 0.001, respectively). Serum concentrations of IL-10, leptin, calprotectin and CRP as well as in WBC count were in the same range in both studied groups. We observed direct statistically significant correlations between levels of IL-10 and CRP (p = 0.005), IL-10 and WBC (p = 0.045), TNF-α and WBC (p = 0.038), calprotectin and WBC (p < 0.001), chemerin and CRP (p < 0.001) as well as between NGAL and WBC (p = 0.002) in children with CMA. Conclusion: The use of a strict milk-free diet by children with CMA, resulting in the resolution of clinical symptoms of the disease, does not seem to extinguish the inflammation induced by the allergy. The findings of this study—elevated IL-6, TNF-α, resistin, chemerin and NGAL levels in patients with CMA—suggest that these parameters seem to be involved in the generation of a low-grade proinflammatory environment observed in cow‘s milk allergy and could be used to monitor the effectiveness of treatment. View Full-Text
Keywords: inflammation; cytokines; calprotectin; pro-inflammatory adipokines; cow’s milk allergy inflammation; cytokines; calprotectin; pro-inflammatory adipokines; cow’s milk allergy
MDPI and ACS Style

Ambroszkiewicz, J.; Gajewska, J.; Chełchowska, M.; Rowicka, G. Assessment of Inflammatory Markers in Children with Cow’s Milk Allergy Treated with a Milk-Free Diet. Nutrients 2021, 13, 1057. https://doi.org/10.3390/nu13041057

AMA Style

Ambroszkiewicz J, Gajewska J, Chełchowska M, Rowicka G. Assessment of Inflammatory Markers in Children with Cow’s Milk Allergy Treated with a Milk-Free Diet. Nutrients. 2021; 13(4):1057. https://doi.org/10.3390/nu13041057

Chicago/Turabian Style

Ambroszkiewicz, Jadwiga, Joanna Gajewska, Magdalena Chełchowska, and Grażyna Rowicka. 2021. "Assessment of Inflammatory Markers in Children with Cow’s Milk Allergy Treated with a Milk-Free Diet" Nutrients 13, no. 4: 1057. https://doi.org/10.3390/nu13041057

Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Back to TopTop