Next Article in Journal
Lifestyle Changes and Determinants of Children’s and Adolescents’ Body Weight Increase during the First COVID-19 Lockdown in Greece: The COV-EAT Study
Previous Article in Journal
Maternal Vitamin C and Iron Intake during Pregnancy and the Risk of Islet Autoimmunity and Type 1 Diabetes in Children: A Birth Cohort Study
Previous Article in Special Issue
Pharmacokinetic Analysis of Carnosic Acid and Carnosol in Standardized Rosemary Extract and the Effect on the Disease Activity Index of DSS-Induced Colitis
Article

Polydatin Prevents Calcium Pyrophosphate Crystal-Induced Arthritis in Mice

1
Rheumatology Unit, Department of Medicine—DIMED, University of Padova, 35128 Padova, Italy
2
Surgical Pathology Unit, Department of Medicine—DIMED, University of Padova, 35128 Padova, Italy
3
Radiology Unit, Department of Medicine—DIMED, University of Padova, 35128 Padova, Italy
4
Institute of Translational Pharmacology-National Research Council, 00133 Rome, Italy
5
Clinical Nutrition Unit, Department of Medicine—DIMED, University of Padova, 35128 Padova, Italy
6
Centre for Gout and Metabolic Bone and Joint Diseases, Rheumatology, SS Giovanni and Paolo Hospital, 30122 Venice, Italy
7
Department of Surgery, Oncology and Gastroenterology-DISCOG, University of Padova, 35128 Padova, Italy
*
Author to whom correspondence should be addressed.
Academic Editor: Dominique Delmas
Nutrients 2021, 13(3), 929; https://doi.org/10.3390/nu13030929
Received: 12 February 2021 / Revised: 7 March 2021 / Accepted: 10 March 2021 / Published: 13 March 2021
(This article belongs to the Special Issue Bioactive Compounds and Chronic Inflammation)
Background: Polydatin is a stilbenoid with important antioxidant, anti-inflammatory, and immunomodulating properties. The aim of this study was to assess the anti-inflammatory preventive effect of polydatin in the mouse model of acute arthritis induced by calcium pyrophosphate (CPP) crystals. Methods: Acute arthritis was induced by the injection of a suspension of sterile CPP crystals into the ankle joint of Balb/c mice. Animals were randomized to receive polydatin or colchicine (the control drug) according to a prophylactic and a therapeutic protocol. The primary outcome was the variation of ankle swelling obtained after crystal injection and treatment, while histological parameters such as leukocyte infiltration, IL-1ß and CXCL1 levels and tissue expression were considered as secondary outcomes. Results: Prophylactic treatment with PD significantly diminished ankle swelling after 48 h from crystal injection. Secondary outcomes such as leukocyte infiltration, necrosis, edema, and synovitis were also decreased. PD caused a reduction in circulating levels of IL-1ß and CXCL1, as well as their tissue expression. By contrast, the therapeutic administration of PD did not have any beneficial effect. Conclusions: PD can effectively prevent acute inflammatory response to crystals in the mouse model of CPP crystal-induced arthritis. These results suggest that this bioactive compound might be used in the prevention of crystal-induced acute attacks in humans. View Full-Text
Keywords: calcium pyrophosphate crystals; inflammation; polydatin; bioactive compounds; crystal-induced arthritis; prevention calcium pyrophosphate crystals; inflammation; polydatin; bioactive compounds; crystal-induced arthritis; prevention
Show Figures

Graphical abstract

MDPI and ACS Style

Oliviero, F.; Galozzi, P.; Scanu, A.; Galuppini, F.; Lazzarin, V.; Brocco, S.; Ravagnan, G.; Sfriso, P.; Ramonda, R.; Spinella, P.; Punzi, L.; Pennelli, G.; Luisetto, R. Polydatin Prevents Calcium Pyrophosphate Crystal-Induced Arthritis in Mice. Nutrients 2021, 13, 929. https://doi.org/10.3390/nu13030929

AMA Style

Oliviero F, Galozzi P, Scanu A, Galuppini F, Lazzarin V, Brocco S, Ravagnan G, Sfriso P, Ramonda R, Spinella P, Punzi L, Pennelli G, Luisetto R. Polydatin Prevents Calcium Pyrophosphate Crystal-Induced Arthritis in Mice. Nutrients. 2021; 13(3):929. https://doi.org/10.3390/nu13030929

Chicago/Turabian Style

Oliviero, Francesca, Paola Galozzi, Anna Scanu, Francesca Galuppini, Vanni Lazzarin, Silvia Brocco, Giampietro Ravagnan, Paolo Sfriso, Roberta Ramonda, Paolo Spinella, Leonardo Punzi, Gianmaria Pennelli, and Roberto Luisetto. 2021. "Polydatin Prevents Calcium Pyrophosphate Crystal-Induced Arthritis in Mice" Nutrients 13, no. 3: 929. https://doi.org/10.3390/nu13030929

Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Back to TopTop