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Open AccessArticle

Impact of Preoperative Total Proteins and Glycated Hemoglobin on Recurrences after Early Colorectal Cancer

1
Faculty of Nursing, University of Valladolid, 47005 Valladolid, Spain
2
Department of Surgery, Dr Sulaiman AlHabib Hospital, Alkhobar 34423, Saudi Arabia
3
Department of Surgery, Hospital de Mieres, 33611 Mieres, Asturias, Spain
4
Department of Surgery, Hospital Severo Ochoa, 28911 Leganés, Madrid, Spain
5
Department of Surgery, Rey Juan Carlos University, 28933 Móstoles, Madrid, Spain
*
Author to whom correspondence should be addressed.
Nutrients 2021, 13(2), 711; https://doi.org/10.3390/nu13020711
Received: 24 January 2021 / Revised: 10 February 2021 / Accepted: 22 February 2021 / Published: 23 February 2021
(This article belongs to the Section Clinical Nutrition)
Background: The outcome of colorectal cancer is mostly based on TNM classification. There are several factors determining that patients with the same tumoral stage present different outcomes. The nutritional status has been related to the immunological response and may affect the oncologic results. The purpose of this study was to determine if preoperative nutritional parameters may predict the oncologic outcome in patients with early colorectal cancer. Methods: A prospective observational study of patients undergoing elective surgery for colorectal cancer was performed with stage I. Preoperative nutritional assessment included glycemic and lipid profiles, total proteins, and albumin levels. These parameters were correlated with tumoral recurrence during a follow-up of at least 24 months. Results: During the period of study, 744 patients were operated on and 228 (30.6%) followed the inclusion criteria for this study. Recurrence rate was 5.7% (13 patients). Patients with hypoproteinemia showed a 7.8-fold greater risk of recurrence during the first 24 months after surgery [OR 7.8 (CI95% 1.3–48), p = 0.012]. Patients with glycated hemoglobin levels (HbA1c) > 6.2% showed a 2.3 increased risk of recurrence [OR 2.3 (CI95% 1.1–4.7; p = 0.01]. Conclusions: Preoperative values of total proteins and HbA1c correlate with the recurrence rate in early colorectal cancer. View Full-Text
Keywords: early colorectal cancer; outcome; total proteins; glycated hemoglobin early colorectal cancer; outcome; total proteins; glycated hemoglobin
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MDPI and ACS Style

Castro, M.-J.; Jiménez, J.-M.; López, M.; Cao, M.-J.; Santos-Torres, J.; López, A.; Moreno, A.; Ruiz-Tovar, J. Impact of Preoperative Total Proteins and Glycated Hemoglobin on Recurrences after Early Colorectal Cancer. Nutrients 2021, 13, 711. https://doi.org/10.3390/nu13020711

AMA Style

Castro M-J, Jiménez J-M, López M, Cao M-J, Santos-Torres J, López A, Moreno A, Ruiz-Tovar J. Impact of Preoperative Total Proteins and Glycated Hemoglobin on Recurrences after Early Colorectal Cancer. Nutrients. 2021; 13(2):711. https://doi.org/10.3390/nu13020711

Chicago/Turabian Style

Castro, María-José; Jiménez, José-María; López, María; Cao, María-José; Santos-Torres, Jair; López, Alberto; Moreno, Ana; Ruiz-Tovar, Jaime. 2021. "Impact of Preoperative Total Proteins and Glycated Hemoglobin on Recurrences after Early Colorectal Cancer" Nutrients 13, no. 2: 711. https://doi.org/10.3390/nu13020711

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