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Article

The Omega-3 Fatty Acid Eicosapentaenoic Acid (EPA) Correlates Inversely with Ischemic Brain Infarcts in Patients with Atrial Fibrillation

1
Department of Internal Medicine, Cantonal Hospital of Baden, 5404 Baden, Switzerland
2
Department of Neurology, University Hospital of Zurich, 8091 Zurich, Switzerland
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Clinical Trial Unit University Hospital of Basel, 4031 Basel, Switzerland
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Center for Molecular Cardiology, Laboratory for Platelet Research, University of Zurich, 8952 Schlieren, Switzerland
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Institute of Anesthesiology, Cantonal Hospital Winterthur, 8400 Winterthur, Switzerland
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Department of Cardiology, University Hospital of Basel, 4031 Basel, Switzerland
7
Cardiovascular Research Institute Basel, University Hospital of Basel, 4031 Basel, Switzerland
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Department of General Internal Medicine, Bern University Hospital, University of Bern, 3010 Bern, Switzerland
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Institute of Primary Health Care (BIHAM), University of Bern, 3010 Bern, Switzerland
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Division of Cardiology, Ospedale Regionale di Lugano, 6900 Ticino, Switzerland
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Department of Neurology and Stroke Center, University Hospital Basel, University of Basel, 4031 Basel, Switzerland
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Royal Brompton and Harefield Hospitals, London SW3 6NP, UK
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Imperial College, London SW7 2BU, UK
14
Population Health Research Institute, McMaster University, Hamilton, ON L8S 4L8, Canada
*
Author to whom correspondence should be addressed.
Academic Editor: Gaetano Santulli
Nutrients 2021, 13(2), 651; https://doi.org/10.3390/nu13020651
Received: 5 January 2021 / Revised: 6 February 2021 / Accepted: 9 February 2021 / Published: 17 February 2021
(This article belongs to the Section Nutritional Epidemiology)
The omega-3 fatty acid (n-3 FA) eicosapentaenoic acid (EPA) reduces stroke in patients with atherosclerotic cardiovascular disease. Whether EPA affects stroke or cerebral small vessel dis-ease in patients with atrial fibrillation (AF) remains uncertain. EPA, docosahexaenoic acid (DHA), docosapentaenoic acid (DPA), and alpha-linolenic acid (ALA) were determined by gas chromatography in 1657 AF patients from the Swiss Atrial Fibrillation study. All patients underwent brain MRI to detect ischemic brain infarcts, classified as large noncortical or cortical infarcts (LNCCIs); markers of small vessel disease, classified as small noncortical infarcts (SNCIs), number of microbleeds, and white matter lesion (WML) volumes. Individual and total n-3 FAs (EPA + DHA + DPA + ALA) were correlated with LNCCIs and SNCIs using logistic regression, with numbers of microbleeds using a hurdle model, and WML volumes using linear regression. LNCCIs were detected in 372 patients (22.5%). EPA correlated inversely with the prevalence of LNCCIs (odds ratio [OR] 0.51 per increase of 1 percentage point EPA, 95% confidence interval [CI] 0.29–0.90). DPA correlated with a higher LNCCI prevalence (OR 2.48, 95%CI 1.49–4.13). No associations with LNCCIs were found for DHA, ALA, and total n-3 FAs. Neither individual nor total n-3 FAs correlated with markers of small vessel disease. In conclusion, EPA correlates inversely with the prevalence of ischemic brain infarcts, but not with markers of small vessel disease in patients with AF. View Full-Text
Keywords: atrial fibrillation; brain ischemia; eicosapentaenoic acid; omega-3 fatty acids; stroke atrial fibrillation; brain ischemia; eicosapentaenoic acid; omega-3 fatty acids; stroke
MDPI and ACS Style

Reiner, M.F.; Baumgartner, P.; Wiencierz, A.; Coslovsky, M.; Bonetti, N.R.; Filipovic, M.G.; Montrasio, G.; Aeschbacher, S.; Rodondi, N.; Baretella, O.; Kühne, M.; Moschovitis, G.; Meyre, P.; Bonati, L.H.; Lüscher, T.F.; Camici, G.G.; Osswald, S.; Conen, D.; Beer, J.H. The Omega-3 Fatty Acid Eicosapentaenoic Acid (EPA) Correlates Inversely with Ischemic Brain Infarcts in Patients with Atrial Fibrillation. Nutrients 2021, 13, 651. https://doi.org/10.3390/nu13020651

AMA Style

Reiner MF, Baumgartner P, Wiencierz A, Coslovsky M, Bonetti NR, Filipovic MG, Montrasio G, Aeschbacher S, Rodondi N, Baretella O, Kühne M, Moschovitis G, Meyre P, Bonati LH, Lüscher TF, Camici GG, Osswald S, Conen D, Beer JH. The Omega-3 Fatty Acid Eicosapentaenoic Acid (EPA) Correlates Inversely with Ischemic Brain Infarcts in Patients with Atrial Fibrillation. Nutrients. 2021; 13(2):651. https://doi.org/10.3390/nu13020651

Chicago/Turabian Style

Reiner, Martin F.; Baumgartner, Philipp; Wiencierz, Andrea; Coslovsky, Michael; Bonetti, Nicole R.; Filipovic, Mark G.; Montrasio, Giulia; Aeschbacher, Stefanie; Rodondi, Nicolas; Baretella, Oliver; Kühne, Michael; Moschovitis, Giorgio; Meyre, Pascal; Bonati, Leo H.; Lüscher, Thomas F.; Camici, Giovanni G.; Osswald, Stefan; Conen, David; Beer, Jürg H. 2021. "The Omega-3 Fatty Acid Eicosapentaenoic Acid (EPA) Correlates Inversely with Ischemic Brain Infarcts in Patients with Atrial Fibrillation" Nutrients 13, no. 2: 651. https://doi.org/10.3390/nu13020651

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