Sarcopenia Risk Evaluation in a Sample of Hospitalized Elderly Men and Women: Combined Use of the Mini Sarcopenia Risk Assessment (MSRA) and the SARC-F
Abstract
:1. Introduction
2. Materials and Methods
2.1. Subjects
2.2. Anthropometry
2.3. Body Composition
2.4. Muscle Strength
2.5. Definition of Sarcopenic Subjects Based on EWGSOP2 Criteria
2.6. SARC-F and Mini Sarcopenia Risk Assessment Questionnaire
2.7. Covariates
2.8. Statistical Analysis
3. Results
4. Discussion
5. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Acknowledgments
Conflicts of Interest
References
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Non Sarcopenic (n = 86) | Sarcopenic (n = 66) | ||||
---|---|---|---|---|---|
Mean ± SD | Min–Max | Mean ± SD | Min–Max | p | |
Age (years) | 79.79 ± 5.47 | 66–93 | 82.88 ± 5.18 | 70–94 | = 0.015 |
Gender (male) | 60 (69.8%) | 34 (51.5%) | N.S. | ||
Weight (kg) | 76.36 ± 14.03 | 51–111 | 64.39 ± 12.06 | 39–91 | <0.001 |
Height (m) | 1.66 ± 0.08 | 1.52–1.80 | 1.62 ± 0.08 | 1.49–1.80 | = 0.022 |
BMI (kg/m2) | 27.40 ± 4.15 | 26.95–29.85 | 24.33 ± 3.74 | 23.15–25.21 | = 0.001 |
ADL score | 5.4 ± 0.4 | 1–6 | 5.0 ± 0.3 | 1–6 | <0.05 |
MMSE | 26.55 ± 3.3 | 21.70–30 | 26.69 ± 2.80 | 21.30–30 | N.S. |
Charlson Comorbidity Index | 2.06 ± 1.56 | 0–8 | 2.75 ± 2.07 | 0–9 | <0.05 |
Charlson Age Comorbidity Index | 5.80 ± 1.83 | 2–12 | 6.53 ± 2.32 | 2–13 | <0.05 |
7-item MSRA score | 23.25 ± 7.06 | 0–35 | 18.93 ± 6.58 | 10–35 | <0.01 |
5-item MSRA score | 35.81 ± 12.43 | 0–55 | 27.87 ± 13.17 | 0–55 | <0.01 |
SARC-F score | 1.60 ± 1.52 | 0–6 | 3.39 ± 2.22 | 0–6 | <0.05 |
7-item MSRA score ≤25 (%) | 16 (18.6%) | 50 (75.7%) | <0.001 | ||
5-item MSRA score ≤40 (%) | 44 (51.2%) | 52 (78.8%) | <0.05 | ||
SARC-F score ≥3 (%) | 18 (20.1%) | 42 (63.6%) | <0.001 | ||
Combined SARC-F/7-item MSRA (%) | 0 (0.0%) | 42 (63.6%) | <0.001 | ||
Combined SARC-F/5-item MSRA (%) | 2 (2.3%) | 28 (42.4%) | <0.001 | ||
Handgrip (kg) | 29.40 ± 8.16 | 10.50−42.50 | 18.88 ± 5.50 | 6.50−26.80 | <0.001 |
Gait-speed (<0.8 m/s) | 14 (41.2%) | 39 (92.9%) | <0.001 | ||
SMI (kg/m2) | 6.85 ± 1.09 | 6.86–7.52 | 5.63 ± 0.74 | 4.23–5.83 | <0.001 |
7-item MSRA | |||
Score | Sensitivity | 1–Specificity | Youden Index |
2.5 | 0.024 | 0 | 0.024 |
7.5 | 0.048 | 0 | 0.048 |
12.5 | 0.190 | 0 | 0.190 |
17.5 | 0.381 | 0.088 | 0.293 |
22.5 | 0.643 | 0.265 | 0.378 |
27.5 | 0.905 | 0.735 | 0.170 |
32.5 | 0.952 | 0.912 | 0.040 |
36 | 1 | 1 | 0 |
5-item MSRA | |||
Score | Sensitivity | 1–Specificity | Youden Index |
5 | 0.071 | 0 | 0.071 |
12.5 | 0.119 | 0.059 | 0.06 |
17.5 | 0.214 | 0.059 | 0.155 |
22.5 | 0.333 | 0.088 | 0.245 |
27.5 | 0.571 | 0.265 | 0.306 |
32.5 | 0.714 | 0.382 | 0.332 |
37.5 | 0.786 | 0.441 | 0.345 |
42.5 | 0.905 | 0.765 | 0.140 |
47.5 | 0.905 | 0.824 | 0.081 |
52.5 | 0.929 | 0.824 | 0.105 |
56 | 1 | 1 | 0 |
SARC-F | |||
Score | Sensitivity | 1–Specificity | Youden Index |
0.5 | 0.881 | 0.706 | 0.175 |
1.5 | 0.69 | 0.471 | 0.219 |
2.5 | 0.524 | 0.235 | 0.289 |
3.5 | 0.333 | 0.118 | 0.215 |
4.5 | 0.286 | 0.118 | 0.168 |
5.5 | 0.095 | 0.088 | 0.007 |
6.5 | 0.048 | 0.029 | 0.019 |
7.5 | 0.024 | 0 | 0.024 |
Specificity | Sensitivity | Negative Predictive Value | Positive Predictive Value | |
---|---|---|---|---|
7-item MSRA score ≤30 | 0.186 | 0.879 | 0.671 | 0.454 |
7-item MSRA score ≤25 (new cut-off) | 0.651 | 0.757 | 0.777 | 0.624 |
5-item MSRA score ≤45 | 0.163 | 0.909 | 0.700 | 0.454 |
5-item MSRA score ≤40 (new cut-off) | 0.679 | 0.688 | 0.739 | 0.622 |
SARC-F score ≥4 | 0.651 | 0.576 | 0.667 | 0.559 |
SARC-F score ≥3 (new cut-off) | 0.765 | 0.524 | 0.677 | 0.631 |
Combined SARC-F/7-item MSRA | 1.00 | 0.636 | 0.782 | 1.00 |
Combined SARC-F/5-item MSRA | 0.977 | 0.424 | 0.689 | 0.934 |
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Rossi, A.P.; Caliari, C.; Urbani, S.; Fantin, F.; Brandimarte, P.; Martini, A.; Zoico, E.; Zoso, G.; Babbanini, A.; Zanotelli, A.; et al. Sarcopenia Risk Evaluation in a Sample of Hospitalized Elderly Men and Women: Combined Use of the Mini Sarcopenia Risk Assessment (MSRA) and the SARC-F. Nutrients 2021, 13, 635. https://doi.org/10.3390/nu13020635
Rossi AP, Caliari C, Urbani S, Fantin F, Brandimarte P, Martini A, Zoico E, Zoso G, Babbanini A, Zanotelli A, et al. Sarcopenia Risk Evaluation in a Sample of Hospitalized Elderly Men and Women: Combined Use of the Mini Sarcopenia Risk Assessment (MSRA) and the SARC-F. Nutrients. 2021; 13(2):635. https://doi.org/10.3390/nu13020635
Chicago/Turabian StyleRossi, Andrea P., Cesare Caliari, Silvia Urbani, Francesco Fantin, Piero Brandimarte, Angela Martini, Elena Zoico, Giulia Zoso, Alessio Babbanini, Alfredo Zanotelli, and et al. 2021. "Sarcopenia Risk Evaluation in a Sample of Hospitalized Elderly Men and Women: Combined Use of the Mini Sarcopenia Risk Assessment (MSRA) and the SARC-F" Nutrients 13, no. 2: 635. https://doi.org/10.3390/nu13020635
APA StyleRossi, A. P., Caliari, C., Urbani, S., Fantin, F., Brandimarte, P., Martini, A., Zoico, E., Zoso, G., Babbanini, A., Zanotelli, A., & Zamboni, M. (2021). Sarcopenia Risk Evaluation in a Sample of Hospitalized Elderly Men and Women: Combined Use of the Mini Sarcopenia Risk Assessment (MSRA) and the SARC-F. Nutrients, 13(2), 635. https://doi.org/10.3390/nu13020635