Next Article in Journal
A Food, a Bite, a Sip: How Much Allergen Is in That?
Next Article in Special Issue
Creatine Supplementation in Children and Adolescents
Previous Article in Journal
Association between Depression, Lifestyles, Sleep Quality, and Sense of Coherence in a Population with Cardiovascular Risk
Previous Article in Special Issue
Potential of Creatine in Glucose Management and Diabetes

Creatine Supplementation and Brain Health

Applied Physiology & Nutrition Research Group, Rheumatology Division, School of Physical Education and Sport, Faculdade de Medicina FMUSP, Universidade de Sao Paulo, Sao Paulo 01246-903, Brazil
Food Research Center, University of São Paulo, Sao Paulo 05508-080, Brazil
FSPE Applied Bioenergetics Lab, University of Novi Sad, 21000 Novi Sad, Serbia
Department of Health, Nutrition, and Exercise Science, Messiah University, Mechanicsburg, PA 17055, USA
Author to whom correspondence should be addressed.
Academic Editor: Richard B. Kreider
Nutrients 2021, 13(2), 586;
Received: 18 January 2021 / Revised: 3 February 2021 / Accepted: 4 February 2021 / Published: 10 February 2021
(This article belongs to the Special Issue Creatine Supplementation for Health and Clinical Diseases)
There is a robust and compelling body of evidence supporting the ergogenic and therapeutic role of creatine supplementation in muscle. Beyond these well-described effects and mechanisms, there is literature to suggest that creatine may also be beneficial to brain health (e.g., cognitive processing, brain function, and recovery from trauma). This is a growing field of research, and the purpose of this short review is to provide an update on the effects of creatine supplementation on brain health in humans. There is a potential for creatine supplementation to improve cognitive processing, especially in conditions characterized by brain creatine deficits, which could be induced by acute stressors (e.g., exercise, sleep deprivation) or chronic, pathologic conditions (e.g., creatine synthesis enzyme deficiencies, mild traumatic brain injury, aging, Alzheimer’s disease, depression). Despite this, the optimal creatine protocol able to increase brain creatine levels is still to be determined. Similarly, supplementation studies concomitantly assessing brain creatine and cognitive function are needed. Collectively, data available are promising and future research in the area is warranted. View Full-Text
Keywords: phosphorylcreatine; dietary supplement; cognition; brain injury; concussion phosphorylcreatine; dietary supplement; cognition; brain injury; concussion
Show Figures

Figure 1

MDPI and ACS Style

Roschel, H.; Gualano, B.; Ostojic, S.M.; Rawson, E.S. Creatine Supplementation and Brain Health. Nutrients 2021, 13, 586.

AMA Style

Roschel H, Gualano B, Ostojic SM, Rawson ES. Creatine Supplementation and Brain Health. Nutrients. 2021; 13(2):586.

Chicago/Turabian Style

Roschel, Hamilton, Bruno Gualano, Sergej M. Ostojic, and Eric S. Rawson 2021. "Creatine Supplementation and Brain Health" Nutrients 13, no. 2: 586.

Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

Back to TopTop