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Review

Beneficial Actions of Orostachys japonica and Its Compounds against Tumors via MAPK Signaling Pathways

by 1,†, 2,3,† and 2,*
1
Department of Clinical Korean Medicine, Graduate School, Kyung Hee University, Seoul 02447, Korea
2
Department of Internal Medicine, College of Korean Medicine, Kyung Hee University, Seoul 02447, Korea
3
Department of Internal Medicine, Kyung Hee University Korean Medicine Hospital, Seoul 02447, Korea
*
Author to whom correspondence should be addressed.
These authors contributed equally to this work.
Academic Editor: Egeria Scoditti
Nutrients 2021, 13(2), 555; https://doi.org/10.3390/nu13020555
Received: 6 January 2021 / Revised: 2 February 2021 / Accepted: 3 February 2021 / Published: 8 February 2021
(This article belongs to the Section Phytochemicals and Human Health)
Tumors are one of the most life-threatening diseases, and a variety of cancer treatment options have been continuously introduced in order to overcome cancer and improve conventional therapy. Orostachys japonica (O. japonica), which is a perennial plant belonging to the genus Orostachys of the Crassulaceae family, has been revealed to exhibit pharmacological properties against various tumors in numerous studies. The present review aimed to discuss the biological actions and underlying molecular mechanisms of O. japonica and its representative compounds—kaempferol and quercetin—against tumors. O. japonica reportedly has antiproliferative, anti-angiogenic, and antimetastatic activities against various types of malignant tumors through the induction of apoptosis and cell cycle arrest, a blockade of downstream vascular endothelial growth factor (VEGF)-VEGFR2 pathways, and the regulation of epithelial-to-mesenchymal transition. In addition, emerging studies have highlighted the antitumor efficacy of kaempferol and quercetin. Interestingly, it was found that alterations of the mitogen-activated protein kinase (MAPK) signaling cascades are involved in the pivotal mechanisms of the antitumor effects of O. japonica and its two compounds against cancer cell overgrowth, angiogenesis, and metastasis. In summary, O. japonica could be considered a preventive and therapeutic medicinal plant which exhibits antitumor actions by reversing altered patterns of MAPK cascades, and kaempferol and quercetin might be potential components that can contribute to the efficacy and underlying mechanism of O. japonica. View Full-Text
Keywords: Orostachys japonica; kaempferol; quercetin; tumor Orostachys japonica; kaempferol; quercetin; tumor
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MDPI and ACS Style

Hur, S.; Jang, E.; Lee, J.-H. Beneficial Actions of Orostachys japonica and Its Compounds against Tumors via MAPK Signaling Pathways. Nutrients 2021, 13, 555. https://doi.org/10.3390/nu13020555

AMA Style

Hur S, Jang E, Lee J-H. Beneficial Actions of Orostachys japonica and Its Compounds against Tumors via MAPK Signaling Pathways. Nutrients. 2021; 13(2):555. https://doi.org/10.3390/nu13020555

Chicago/Turabian Style

Hur, Soyoung, Eungyeong Jang, and Jang-Hoon Lee. 2021. "Beneficial Actions of Orostachys japonica and Its Compounds against Tumors via MAPK Signaling Pathways" Nutrients 13, no. 2: 555. https://doi.org/10.3390/nu13020555

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