Next Article in Journal
Trends in Diet Quality and Related Sociodemographic, Health, and Occupational Characteristics among Workers in Spain: Results from Three Consecutive National Health Surveys (2006–2017)
Next Article in Special Issue
Relationship between the Gut Microbiome and Osteoarthritis Pain: Review of the Literature
Previous Article in Journal
Hypothalamic Inflammation as a Potential Pathophysiologic Basis for the Heterogeneity of Clinical, Hormonal, and Metabolic Presentation in PCOS
 
 
Article

The Influence of Specific Bioactive Collagen Peptides on Knee Joint Discomfort in Young Physically Active Adults: A Randomized Controlled Trial

1
Department for Nutrition, Institute for Sports and Sports Science, University of Freiburg, Schwarzwaldstr. 175, 79117 Freiburg, Germany
2
CRI, Collagen Research Institute, Schauenburgerstr 116, 24118 Kiel, Germany
3
Centre of Sports Science, Department for Sports, Nutrition and Health, University of Vienna, Auf der Schmelz 6, Vienna 1150, Austria
4
Faculty of Life Sciences, Department for Sports, Nutrition and Health, University of Vienna, Althanstrasse 14, Vienna 1090, Austria
*
Author to whom correspondence should be addressed.
Academic Editors: Sara Baldassano and Bernard Venn
Nutrients 2021, 13(2), 523; https://doi.org/10.3390/nu13020523
Received: 1 December 2020 / Revised: 12 January 2021 / Accepted: 2 February 2021 / Published: 5 February 2021
(This article belongs to the Special Issue The Effect of Collagen Consumption on Human Health)
First evidence indicates that the supplementation of specific collagen peptides is associated with a significant reduction in activity-related joint pain in young adults. The purpose of the current investigation was to confirm the efficacy of the same collagen peptides in a comparable study population. In total, 180 active men and women aged between 18 and 30 years with exercise-related knee pain but no diagnosed joint disease completed the trial over a period of 12 weeks. Participants were randomly assigned to the group receiving 5 g of specific collagen peptides (CP-G) or to the placebo group (P-G). For the primary outcome, changes in pain during or after exercise from pre- to post-intervention were assessed by the participants using the Visual Analog Scale (VAS). These changes were additionally evaluated by the examining physician by means of anamnesis and physical examination of the affected knee joint. As secondary outcomes, pain under resting conditions and after 20 squats were compared between the study groups. In addition, the mobility of the knee joint and the use of alternative therapies (e.g., ointments or physiotherapy) were recorded. The supplementation of specific collagen peptides derived from type I collagen with a mean molecular weight of 3 kDa led to a significantly (p = 0.024) higher reduction of exercise-induced knee pain (−21.9 ± 18.3 mm) compared with the placebo group (−15.6 ± 18.5 mm). These findings were consistent with the physician’s evaluation (−23.0 ± 19.2 mm vs. −14.6 ± 17.9 mm, p = 0.003). The decrease in pain under resting conditions and after squats did not significantly differ between the groups, as only a small number of participants suffered from pain under these conditions. Due to the clinically unremarkable baseline values, the mobility of the knee joint did not change significantly after the intervention. In conclusion, the current investigation confirmed that the oral intake of bioactive collagen peptides used in the current investigation led to a statistically significant reduction of activity-related joint pain in young active adults suffering from knee joint discomfort. View Full-Text
Keywords: activity-related knee pain; collagen peptides; VAS; range of motion; pain reduction activity-related knee pain; collagen peptides; VAS; range of motion; pain reduction
Show Figures

Figure 1

MDPI and ACS Style

Zdzieblik, D.; Brame, J.; Oesser, S.; Gollhofer, A.; König, D. The Influence of Specific Bioactive Collagen Peptides on Knee Joint Discomfort in Young Physically Active Adults: A Randomized Controlled Trial. Nutrients 2021, 13, 523. https://doi.org/10.3390/nu13020523

AMA Style

Zdzieblik D, Brame J, Oesser S, Gollhofer A, König D. The Influence of Specific Bioactive Collagen Peptides on Knee Joint Discomfort in Young Physically Active Adults: A Randomized Controlled Trial. Nutrients. 2021; 13(2):523. https://doi.org/10.3390/nu13020523

Chicago/Turabian Style

Zdzieblik, Denise, Judith Brame, Steffen Oesser, Albert Gollhofer, and Daniel König. 2021. "The Influence of Specific Bioactive Collagen Peptides on Knee Joint Discomfort in Young Physically Active Adults: A Randomized Controlled Trial" Nutrients 13, no. 2: 523. https://doi.org/10.3390/nu13020523

Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Back to TopTop