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Aberrance of Zinc Metalloenzymes-Induced Human Diseases and Its Potential Mechanisms

by 1,2 and 2,*
1
Queen Mary School, Medical College, Nanchang University, Nanchang 330006, China
2
Department of Histology and Embryology, Medical College, Nanchang University, Nanchang 330006, China
*
Author to whom correspondence should be addressed.
Academic Editor: Hajo Haase
Nutrients 2021, 13(12), 4456; https://doi.org/10.3390/nu13124456
Received: 8 November 2021 / Revised: 6 December 2021 / Accepted: 9 December 2021 / Published: 13 December 2021
(This article belongs to the Section Micronutrients and Human Health)
Zinc, an essential micronutrient in the human body, is a component in over 300 enzymes and participates in regulating enzymatic activity. Zinc metalloenzymes play a crucial role in physiological processes including antioxidant, anti-inflammatory, and immune responses, as well as apoptosis. Aberrant enzyme activity can lead to various human diseases. In this review, we summarize zinc homeostasis, the roles of zinc in zinc metalloenzymes, the physiological processes of zinc metalloenzymes, and aberrant zinc metalloenzymes in human diseases. In addition, potential mechanisms of action are also discussed. This comprehensive understanding of the mechanisms of action of the regulatory functions of zinc in enzyme activity could inform novel zinc-micronutrient-supply strategies for the treatment of diseases. View Full-Text
Keywords: zinc; zinc metalloenzyme; enzyme activity; human disease zinc; zinc metalloenzyme; enzyme activity; human disease
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MDPI and ACS Style

Cheng, Y.; Chen, H. Aberrance of Zinc Metalloenzymes-Induced Human Diseases and Its Potential Mechanisms. Nutrients 2021, 13, 4456. https://doi.org/10.3390/nu13124456

AMA Style

Cheng Y, Chen H. Aberrance of Zinc Metalloenzymes-Induced Human Diseases and Its Potential Mechanisms. Nutrients. 2021; 13(12):4456. https://doi.org/10.3390/nu13124456

Chicago/Turabian Style

Cheng, Yunqi, and Hongping Chen. 2021. "Aberrance of Zinc Metalloenzymes-Induced Human Diseases and Its Potential Mechanisms" Nutrients 13, no. 12: 4456. https://doi.org/10.3390/nu13124456

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