Next Article in Journal
Oyster Hydrolysates Attenuate Muscle Atrophy via Regulating Protein Turnover and Mitochondria Biogenesis in C2C12 Cell and Immobilized Mice
Previous Article in Journal
Natural and Synthetic Bioactives for Skin Health, Disease and Management
Article

Nutrient Intake and Gut Microbial Genera Changes after a 4-Week Placebo Controlled Galacto-Oligosaccharides Intervention in Young Females

1
School of Psychology, Faculty of Health and Medical Sciences, University of Surrey, Guildford GU2 7XH, UK
2
FrieslandCampina, 3818 LA Amersfoort, The Netherlands
3
Department of Nutritional Sciences, School of Biosciences and Medicine, Faculty of Health and Medical Sciences, University of Surrey, Guildford GU2 7XH, UK
*
Authors to whom correspondence should be addressed.
Academic Editor: M. Andrea Azcarate-Peril
Nutrients 2021, 13(12), 4384; https://doi.org/10.3390/nu13124384
Received: 4 November 2021 / Revised: 1 December 2021 / Accepted: 3 December 2021 / Published: 8 December 2021
(This article belongs to the Section Prebiotics and Probiotics)
Recent interest in the gut-brain-axis has highlighted the potential of prebiotics to impact wellbeing, and to affect behavioral change in humans. In this clinical trial, we examined the impact of four-weeks daily supplementation of galacto-oligosaccharides (GOS) on self-reported nutrient intake and relationships on gut microbiota in a four-week two-armed parallel double-blind placebo controlled GOS supplement trial in young adult females. Food diaries and stool samples were collected prior to and following 28 days of supplement consumption. It was found that four weeks of GOS supplementation influenced macronutrient intake, as evident by reduced carbohydrate and sugars and increased fats intake. Further analysis showed that the reduction in carbohydrates was predicted by increasing abundances of Bifidobacterium in the GOS group in comparison to the placebo group. This suggests that Bifidobacterium increase via GOS supplementation may help improve the gut microbiota composition by altering the desire for specific types of carbohydrates and boosting Bifidobacterium availability when fiber intake is below recommended levels, without compromising appetite for fiber from food. View Full-Text
Keywords: GOS; intervention; gut microbiota GOS; intervention; gut microbiota
Show Figures

Graphical abstract

MDPI and ACS Style

Johnstone, N.; Dart, S.; Knytl, P.; Nauta, A.; Hart, K.; Cohen Kadosh, K. Nutrient Intake and Gut Microbial Genera Changes after a 4-Week Placebo Controlled Galacto-Oligosaccharides Intervention in Young Females. Nutrients 2021, 13, 4384. https://doi.org/10.3390/nu13124384

AMA Style

Johnstone N, Dart S, Knytl P, Nauta A, Hart K, Cohen Kadosh K. Nutrient Intake and Gut Microbial Genera Changes after a 4-Week Placebo Controlled Galacto-Oligosaccharides Intervention in Young Females. Nutrients. 2021; 13(12):4384. https://doi.org/10.3390/nu13124384

Chicago/Turabian Style

Johnstone, Nicola, Susannah Dart, Paul Knytl, Arjen Nauta, Kathryn Hart, and Kathrin Cohen Kadosh. 2021. "Nutrient Intake and Gut Microbial Genera Changes after a 4-Week Placebo Controlled Galacto-Oligosaccharides Intervention in Young Females" Nutrients 13, no. 12: 4384. https://doi.org/10.3390/nu13124384

Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Back to TopTop