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Article

Effect of Vitamin E Supplement on Bone Turnover Markers in Postmenopausal Osteopenic Women: A Double-Blind, Randomized, Placebo-Controlled Trial

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Faculty of Medicine, Bangkokthonburi University, Bangkok 10170, Thailand
2
Child Safety Promotion and Injury Prevention Research Center, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok 10400, Thailand
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Woman Health Centre, Chulabhorn Hospital, HRH Princess Chulabhorn College of Medical Science, Chulabhorn Royal Academy, Bangkok 10210, Thailand
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Reproductive, Endocrinology & Infertility Unit, Department of Obstetrics and Gynaecology, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok 10400, Thailand
*
Author to whom correspondence should be addressed.
Academic Editor: Jose M. Moran
Nutrients 2021, 13(12), 4226; https://doi.org/10.3390/nu13124226
Received: 31 October 2021 / Revised: 19 November 2021 / Accepted: 22 November 2021 / Published: 25 November 2021
(This article belongs to the Special Issue Nutrition and Women Bone Health)
Vitamin E is a strong anti-oxidative stress agent that affects the bone remodeling process. This study evaluates the effect of mixed-tocopherol supplements on bone remodeling in postmenopausal osteopenic women. A double-blinded, randomized, placebo-controlled trial study was designed to measure the effect of mixed-tocopherol on the bone turnover marker after 12 weeks of supplementation. All 52 osteopenic postmenopausal women were enrolled and allocated into two groups. The intervention group received mixed-tocopherol 400 IU/day, while the control group received placebo tablets. Fifty-two participants completed 12 weeks of follow-up. Under an intention-to-treat analysis, vitamin E produced a significant difference in the mean bone resorption marker (serum C-terminal telopeptide of type I collagen (CTX)) compared with the placebo group (−0.003 ± 0.09 and 0.121 ± 0.15, respectively (p < 0.001)). In the placebo group, the CTX had increased by 35.3% at 12 weeks of supplementation versus baseline (p < 0.001), while, in the vitamin E group, there was no significant change of bone resorption marker (p < 0.898). In conclusion, vitamin E (mixed-tocopherol) supplementation in postmenopausal osteopenic women may have a preventive effect on bone loss through anti-resorptive activity. View Full-Text
Keywords: vitamin E; bone turnover; osteopenia; postmenopausal women; tocopherol; bone marker turnover; bone health vitamin E; bone turnover; osteopenia; postmenopausal women; tocopherol; bone marker turnover; bone health
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MDPI and ACS Style

Vallibhakara, S.A.-O.; Nakpalat, K.; Sophonsritsuk, A.; Tantitham, C.; Vallibhakara, O. Effect of Vitamin E Supplement on Bone Turnover Markers in Postmenopausal Osteopenic Women: A Double-Blind, Randomized, Placebo-Controlled Trial. Nutrients 2021, 13, 4226. https://doi.org/10.3390/nu13124226

AMA Style

Vallibhakara SA-O, Nakpalat K, Sophonsritsuk A, Tantitham C, Vallibhakara O. Effect of Vitamin E Supplement on Bone Turnover Markers in Postmenopausal Osteopenic Women: A Double-Blind, Randomized, Placebo-Controlled Trial. Nutrients. 2021; 13(12):4226. https://doi.org/10.3390/nu13124226

Chicago/Turabian Style

Vallibhakara, Sakda A.-O., Katanyuta Nakpalat, Areepan Sophonsritsuk, Chananya Tantitham, and Orawin Vallibhakara. 2021. "Effect of Vitamin E Supplement on Bone Turnover Markers in Postmenopausal Osteopenic Women: A Double-Blind, Randomized, Placebo-Controlled Trial" Nutrients 13, no. 12: 4226. https://doi.org/10.3390/nu13124226

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