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Article

Gut Microbiota and Mycobiota Evolution Is Linked to Memory Improvement after Bariatric Surgery in Obese Patients: A Pilot Study

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Centre Hospitalier de Bordeaux, CRCM Pédiatrique, CIC 1401, 33000 Bordeaux, France
2
Centre de Recherche Cardio-Thoracique de Bordeaux, U1045, Hôpital Xavier Arnozan, University of Bordeaux, Avenue du Haut Lévêque, 33604 Pessac, France
3
Centre Hospitalier de Bordeaux, University of Bordeaux, FHU ACRONIM, 33000 Bordeaux, France
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Centre Hospitalier de Bordeaux, Department of Endocrinology, Diabetes and Nutrition, University Hospital of Bordeaux, 33604 Pessac, France
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Neurocentre Magendie, Physiopathologie de la Plasticité Neuronale, U862, INSERM, 146 rue Léo Saignat, 33076 Bordeaux, France
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BIOGECO, INRAE, University of Bordeaux, 69 route d’Arcachon, 33610 Cestas, France
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Centre Hospitalier de Bordeaux, University of Bordeaux, FHU TALISMENT, 33000 Bordeaux, France
*
Author to whom correspondence should be addressed.
These authors contributed equally.
Academic Editors: Kathrin Cohen Kadosh and Krzysztof Czaja
Nutrients 2021, 13(11), 4061; https://doi.org/10.3390/nu13114061
Received: 16 October 2021 / Revised: 7 November 2021 / Accepted: 11 November 2021 / Published: 13 November 2021
(This article belongs to the Special Issue Gut Microbiota and Cognitive Function)
Patients with obesity are known to exhibit gut microbiota dysbiosis and memory deficits. Bariatric surgery (BS) is currently the most efficient anti-obesity treatment and may improve both gut dysbiosis and cognition. However, no study has investigated association between changes of gut microbiota and cognitive function after BS. We prospectively evaluated 13 obese patients on anthropometric data, memory functions, and gut microbiota-mycobiota before and six months after BS. The Rey Auditory Verbal Learning Test (AVLT) and the symbol span (SS) of the Weschler Memory Scale were used to assess verbal and working memory, respectively. Fecal microbiota and mycobiota were longitudinally analyzed by 16S and ITS2 rRNA sequencing respectively. AVLT and SS scores were significantly improved after BS (AVLT scores: 9.7 ± 1.7 vs. 11.2 ± 1.9, p = 0.02, and SS scores: 9.7 ± 23.0 vs. 11.6 ± 2.9, p = 0.05). An increase in bacterial alpha-diversity, and Ruminococcaceae, Prevotella, Agaricus, Rhodotorula, Dipodascus, Malassezia, and Mucor were significantly associated with AVLT score improvement after BS, while an increase in Prevotella and a decrease in Clostridium, Akkermansia, Dipodascus and Candida were linked to SS scores improvement. We identified several changes in the microbial communities that differ according to the improvement of either the verbal or working memories, suggesting a complex gut-brain-axis that evolves after BS. View Full-Text
Keywords: cognition; memory; metagenomics; microbiome; microbiota; mycobiota; obesity; bariatric surgery cognition; memory; metagenomics; microbiome; microbiota; mycobiota; obesity; bariatric surgery
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MDPI and ACS Style

Enaud, R.; Cambos, S.; Viaud, E.; Guichoux, E.; Chancerel, E.; Marighetto, A.; Etchamendy, N.; Clark, S.; Mohammedi, K.; Cota, D.; Delhaes, L.; Gatta-Cherifi, B. Gut Microbiota and Mycobiota Evolution Is Linked to Memory Improvement after Bariatric Surgery in Obese Patients: A Pilot Study. Nutrients 2021, 13, 4061. https://doi.org/10.3390/nu13114061

AMA Style

Enaud R, Cambos S, Viaud E, Guichoux E, Chancerel E, Marighetto A, Etchamendy N, Clark S, Mohammedi K, Cota D, Delhaes L, Gatta-Cherifi B. Gut Microbiota and Mycobiota Evolution Is Linked to Memory Improvement after Bariatric Surgery in Obese Patients: A Pilot Study. Nutrients. 2021; 13(11):4061. https://doi.org/10.3390/nu13114061

Chicago/Turabian Style

Enaud, Raphaël, Sophie Cambos, Esther Viaud, Erwan Guichoux, Emilie Chancerel, Aline Marighetto, Nicole Etchamendy, Samantha Clark, Kamel Mohammedi, Daniela Cota, Laurence Delhaes, and Blandine Gatta-Cherifi. 2021. "Gut Microbiota and Mycobiota Evolution Is Linked to Memory Improvement after Bariatric Surgery in Obese Patients: A Pilot Study" Nutrients 13, no. 11: 4061. https://doi.org/10.3390/nu13114061

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