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Article

Cordyceps militaris Fruit Body Extract Decreases Testosterone Catabolism and Testosterone-Stimulated Prostate Hypertrophy

1
Department of Endocrine Pharmacology, Tokyo University of Pharmacy and Life Sciences, Tokyo 192-0392, Japan
2
Department of Biomolecular Organic Chemistry, Tokyo University of Pharmacy and Life Sciences, Tokyo 192-0392, Japan
3
Faculty of Advanced Life Science, Hokkaido University, Sapporo 060-8648, Japan
4
Okinawa UKAMI Sericulture Co. Ltd. Heshiki, Nakijin-Son, Kunigami-Gun, Okinawa 905-0423, Japan
*
Author to whom correspondence should be addressed.
Both authors contributed equally to this work.
Nutrients 2021, 13(1), 50; https://doi.org/10.3390/nu13010050
Received: 16 December 2020 / Revised: 23 December 2020 / Accepted: 24 December 2020 / Published: 26 December 2020
(This article belongs to the Section Nutrition and Public Health)
The androgens testosterone and dihydrotestosterone (DHT) are essential for a variety of systemic functions in mature males. Alteration of these hormones results in late-onset hypogonadism (LOH) and benign prostate hyperplasia (BPH). The fruit bodies of fungi of the genus Cordyceps have been regarded as folk medicine or health food with tonic and antifatigue effects. The extract from the fruit body of Cordyceps militaris parasitizing Samia cynthia ricini (CM) was evaluated as a novel-candidate natural product for ameliorating male andropause symptoms. To explore the effects of CM on LOH and BPH, CM was applied to rat models and cultured testicular cells and prostate cells. The concentrations of androgens in the serum and culture media were determined by ELISA. Expression of steroidogenic enzymes and androgen-related genes was evaluated by qPCR, and prostatic cell proliferation was assessed with the cell-viability assay. CM maintained the serum levels of testosterone and DHT, but inhibited testosterone-induced prostate hypertrophy. CM also increased the secretion of testosterone and DHT by primary testicular cells, with no changes in the mRNA expression of steroidogenic enzymes, but decreased the growth of prostatic cell lines. Our data suggest that CM could improve both LOH and BPH in males. View Full-Text
Keywords: Cordyceps militaris; testosterone; late-onset hypogonadism (LOH); prostate; benign prostate hyperplasia (BPH) Cordyceps militaris; testosterone; late-onset hypogonadism (LOH); prostate; benign prostate hyperplasia (BPH)
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MDPI and ACS Style

Kusama, K.; Miyagawa, M.; Ota, K.; Kuwabara, N.; Saeki, K.; Ohnishi, Y.; Kumaki, Y.; Aizawa, T.; Nakasone, T.; Okamatsu, S.; Miyaoka, H.; Tamura, K. Cordyceps militaris Fruit Body Extract Decreases Testosterone Catabolism and Testosterone-Stimulated Prostate Hypertrophy. Nutrients 2021, 13, 50. https://doi.org/10.3390/nu13010050

AMA Style

Kusama K, Miyagawa M, Ota K, Kuwabara N, Saeki K, Ohnishi Y, Kumaki Y, Aizawa T, Nakasone T, Okamatsu S, Miyaoka H, Tamura K. Cordyceps militaris Fruit Body Extract Decreases Testosterone Catabolism and Testosterone-Stimulated Prostate Hypertrophy. Nutrients. 2021; 13(1):50. https://doi.org/10.3390/nu13010050

Chicago/Turabian Style

Kusama, Kazuya, Mayuko Miyagawa, Koichiro Ota, Naoko Kuwabara, Kaori Saeki, Yuki Ohnishi, Yasuhiro Kumaki, Tomoyasu Aizawa, Toyokazu Nakasone, Shigemi Okamatsu, Hiroaki Miyaoka, and Kazuhiro Tamura. 2021. "Cordyceps militaris Fruit Body Extract Decreases Testosterone Catabolism and Testosterone-Stimulated Prostate Hypertrophy" Nutrients 13, no. 1: 50. https://doi.org/10.3390/nu13010050

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