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Article

Prevalence and Impact of Vitamin D Deficiency in Critically Ill Cancer Patients Admitted to the Intensive Care Unit

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Intensive Care Unit 13i2, Department of Medicine I, Medical University of Vienna, 1090 Vienna, Austria
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Intensive Care Unit 13H1, Department of Medicine III, Division of Gastroenterology & Hepatology, Medical University of Vienna, 1090 Vienna, Austria
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Intensive Care Unit 13H3, Department of Medicine II, Division of Cardiology, Medical University of Vienna, 1090 Vienna, Austria
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Intensive Care Unit 13i3, Department of Medicine III, Division of Nephrology, Medical University of Vienna, 1090 Vienna, Austria
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Department of Medicine I, Division of Hematology, Medical University of Vienna, 1090 Vienna, Austria
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Stem Cell Transplantation Unit, Department of Medicine I, Medical University of Vienna, 1090 Vienna, Austria
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Author to whom correspondence should be addressed.
Nutrients 2021, 13(1), 22; https://doi.org/10.3390/nu13010022
Received: 30 October 2020 / Revised: 19 December 2020 / Accepted: 21 December 2020 / Published: 23 December 2020
(This article belongs to the Special Issue Nutrition and Metabolism in Critical Care)
Vitamin D deficiency is frequent in cancer patients and a risk factor for morbidity and mortality during critical illness. This single-center retrospective study analyzed 25-hydroxyvitamin D levels in critically ill cancer patients (n = 178; hematologic, n = 108; solid, n = 70) enrolled in a prospective ICU registry. The primary analysis was the prevalence of vitamin D deficiency (<20 ng/mL) and the severe deficiency (≤12 ng/mL). Secondary analyses included risk factors for vitamin D deficiency and its impact on ICU, hospital, and 1-year mortality. The prevalence of vitamin D deficiency and severe deficiency was 74% (95% CI: 67–80%) and 54% (95% CI: 47–61%). Younger age, relapsed/refractory disease, and a higher sepsis-related organ failure assessment (SOFA) score were independent risk factors for vitamin D deficiency (p < 0.05). After adjusting for relapsed/refractory disease, infection, the SOFA score, and the early need for life-supporting interventions, severe vitamin D deficiency was an independent predictor of hospital mortality (OR: 2.21, 95% CI: 1.03–4.72, p = 0.04) and 1-year mortality (OR: 3.40, 95% CI: 1.50–7.71, p < 0.01), but not of ICU mortality. Conclusion: Vitamin D deficiency is common in critically ill cancer patients requiring ICU admission, but its impact on short-term mortality in this group is uncertain. The observed association of severe vitamin D deficiency with the post-ICU outcome warrants clinical consideration and further study. View Full-Text
Keywords: vitamin D; intensive care unit; cancer; oncology; hematology vitamin D; intensive care unit; cancer; oncology; hematology
MDPI and ACS Style

Buchtele, N.; Lobmeyr, E.; Cserna, J.; Zauner, C.; Heinz, G.; Sengölge, G.; Sperr, W.R.; Staudinger, T.; Schellongowski, P.; Wohlfarth, P. Prevalence and Impact of Vitamin D Deficiency in Critically Ill Cancer Patients Admitted to the Intensive Care Unit. Nutrients 2021, 13, 22. https://doi.org/10.3390/nu13010022

AMA Style

Buchtele N, Lobmeyr E, Cserna J, Zauner C, Heinz G, Sengölge G, Sperr WR, Staudinger T, Schellongowski P, Wohlfarth P. Prevalence and Impact of Vitamin D Deficiency in Critically Ill Cancer Patients Admitted to the Intensive Care Unit. Nutrients. 2021; 13(1):22. https://doi.org/10.3390/nu13010022

Chicago/Turabian Style

Buchtele, Nina, Elisabeth Lobmeyr, Julia Cserna, Christian Zauner, Gottfried Heinz, Gürkan Sengölge, Wolfgang R. Sperr, Thomas Staudinger, Peter Schellongowski, and Philipp Wohlfarth. 2021. "Prevalence and Impact of Vitamin D Deficiency in Critically Ill Cancer Patients Admitted to the Intensive Care Unit" Nutrients 13, no. 1: 22. https://doi.org/10.3390/nu13010022

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