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Open AccessArticle

The Association between 25-Hydroxyvitamin D Concentration and Disability Trajectories in Very Old Adults: The Newcastle 85+ Study

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Population Health Sciences Institute, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne NE2 4HH, UK
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Human Nutrition Research Centre, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne NE2 4HH, UK
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College of Nursing, Umm Al-Quraa University, Makkah 715, Saudi Arabia
4
EpiDoC Unit, NOVA Medical School, Universidade Nova de Lisboa (NMS-UNL), 1150-082 Lisbon, Portugal
5
Comprehensive Health Research Centre (CHRC), NOVA Medical School, Universidade Nova de Lisboa, 1150-082 Lisbon, Portugal
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Translational and Clinical Research Institute, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne NE2 4HH, UK
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Freeman Hospital, NHS, Newcastle upon Tyne NE7 7DN, UK
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Bioscreening Core Facility, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne NE4 5 PL, UK
*
Author to whom correspondence should be addressed.
Nutrients 2020, 12(9), 2742; https://doi.org/10.3390/nu12092742
Received: 31 July 2020 / Revised: 26 August 2020 / Accepted: 7 September 2020 / Published: 9 September 2020
(This article belongs to the Special Issue Vitamin D in 2020: Stop or Not Yet?)
Background: Low vitamin D status is common in very old adults which may have adverse consequences for muscle function, a major predictor of disability. Aims: To explore the association between 25-hydroxyvitamin D [25(OH)D] concentrations and disability trajectories in very old adults and to determine whether there is an ‘adequate’ 25(OH)D concentration which might protect against a faster disability trajectory. Methodology: A total of 775 participants from the Newcastle 85+ Study for who 25(OH)D concentration at baseline was available. Serum 25(OH)D concentrations of <25 nmol/L, 25–50 nmol/L and >50 nmol/L were used as cut-offs to define low, moderate and high vitamin D status, respectively. Disability was defined as difficulty in performing 17 activities of daily living, at baseline, after 18, 36 and 60 months. Results: A three-trajectory model was derived (low-to-mild, mild-to-moderate and moderate-to-severe). In partially adjusted models, participants with 25(OH)D concentrations <25 nmol/L were more likely to have moderate and severe disability trajectories, even after adjusting for sex, living in an institution, season, cognitive status, BMI and vitamin D supplement use. However, this association disappeared after further adjustment for physical activity. Conclusions: Vitamin D status does not appear to influence the trajectories of disability in very old adults. View Full-Text
Keywords: vitamin D status; disability; very old adults vitamin D status; disability; very old adults
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Hakeem, S.; Mendonca, N.; Aspray, T.; Kingston, A.; Ruiz-Martin, C.; Jagger, C.; Mathers, J.C.; Duncan, R.; Hill, T.R. The Association between 25-Hydroxyvitamin D Concentration and Disability Trajectories in Very Old Adults: The Newcastle 85+ Study. Nutrients 2020, 12, 2742.

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