Next Article in Journal
The Effects of Ultra-Processed Food Consumption—Is There Any Action Needed?
Next Article in Special Issue
Omega-3 Polyunsaturated Fatty Acids EPA and DHA as an Adjunct to Non-Surgical Treatment of Periodontitis: A Randomized Clinical Trial
Previous Article in Journal
Inputs to Thirst and Drinking during Water Restriction and Rehydration
Previous Article in Special Issue
The Effects of Linoleic Acid Consumption on Lipid Risk Markers for Cardiovascular Disease in Healthy Individuals: A Review of Human Intervention Trials
Open AccessReview

Expert Opinion on Benefits of Long-Chain Omega-3 Fatty Acids (DHA and EPA) in Aging and Clinical Nutrition

1
Nutrition Science and Advocacy, DSM Nutritional Products, 4303 Kaiseraugst, Switzerland
2
Department of Internal Medicine, University Medical Center Groningen, 9713 GZ Groningen, The Netherlands
3
Department of Translational and Precision Medicine, Sapienza University, 00185 Rome, Italy
4
Gérontopôle de Toulouse, Institut du Vieillissement, INSERM 1027, Centre Hospitalo-Universitaire de Toulouse, 31300 Toulouse, France
5
Department of Pharmacology, University of Oxford, Oxford OX1 2JD, UK
6
Clinic for General, Visceral and Oncological Surgery, St. Georg gGmbH Clinic, 04129 Leipzig, Germany
7
Faculty of Medicine, University of Southampton and NIHR Southampton Biomedical Research Centre, University Hospital Southampton NHS Foundation Trust and University of Southampton, Southampton SO16 6YD, UK
*
Author to whom correspondence should be addressed.
Nutrients 2020, 12(9), 2555; https://doi.org/10.3390/nu12092555
Received: 18 July 2020 / Revised: 20 August 2020 / Accepted: 21 August 2020 / Published: 24 August 2020
(This article belongs to the Special Issue Polyunsaturated Fatty Acids Intake and Human Health)
Life expectancy is increasing and so is the prevalence of age-related non-communicable diseases (NCDs). Consequently, older people and patients present with multi-morbidities and more complex needs, putting significant pressure on healthcare systems. Effective nutrition interventions could be an important tool to address patient needs, improve clinical outcomes and reduce healthcare costs. Inflammation plays a central role in NCDs, so targeting it is relevant to disease prevention and treatment. The long-chain omega-3 polyunsaturated fatty acids (omega-3 LCPUFAs) docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA) are known to reduce inflammation and promote its resolution, suggesting a beneficial role in various therapeutic areas. An expert group reviewed the data on omega-3 LCPUFAs in specific patient populations and medical conditions. Evidence for benefits in cognitive health, age- and disease-related decline in muscle mass, cancer treatment, surgical patients and critical illness was identified. Use of DHA and EPA in some conditions is already included in some relevant guidelines. However, it is important to note that data on the effects of omega-3 LCPUFAs are still inconsistent in many areas (e.g., cognitive decline) due to a range of factors that vary amongst the trials performed to date; these factors include dose, timing and duration; baseline omega-3 LCPUFA status; and intake of other nutrients. Well-designed intervention studies are required to optimize the effects of DHA and EPA in specific patient populations and to develop more personalized strategies for their use. View Full-Text
Keywords: clinical nutrition; oral nutritional supplementation; DHA and EPA; long-chain omega-3 polyunsaturated fatty acids; inflammation; Alzheimer’s disease; immunonutrition; frailty; sarcopenia; cancer cachexia clinical nutrition; oral nutritional supplementation; DHA and EPA; long-chain omega-3 polyunsaturated fatty acids; inflammation; Alzheimer’s disease; immunonutrition; frailty; sarcopenia; cancer cachexia
Show Figures

Figure 1

MDPI and ACS Style

Troesch, B.; Eggersdorfer, M.; Laviano, A.; Rolland, Y.; Smith, A.D.; Warnke, I.; Weimann, A.; Calder, P.C. Expert Opinion on Benefits of Long-Chain Omega-3 Fatty Acids (DHA and EPA) in Aging and Clinical Nutrition. Nutrients 2020, 12, 2555. https://doi.org/10.3390/nu12092555

AMA Style

Troesch B, Eggersdorfer M, Laviano A, Rolland Y, Smith AD, Warnke I, Weimann A, Calder PC. Expert Opinion on Benefits of Long-Chain Omega-3 Fatty Acids (DHA and EPA) in Aging and Clinical Nutrition. Nutrients. 2020; 12(9):2555. https://doi.org/10.3390/nu12092555

Chicago/Turabian Style

Troesch, Barbara; Eggersdorfer, Manfred; Laviano, Alessandro; Rolland, Yves; Smith, A. D.; Warnke, Ines; Weimann, Arved; Calder, Philip C. 2020. "Expert Opinion on Benefits of Long-Chain Omega-3 Fatty Acids (DHA and EPA) in Aging and Clinical Nutrition" Nutrients 12, no. 9: 2555. https://doi.org/10.3390/nu12092555

Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Search more from Scilit
 
Search
Back to TopTop