Next Article in Journal
Disparities in the Healthfulness of School Food Environments and the Nutritional Quality of School Lunches
Previous Article in Journal
Addressing Challenges with the Categorization of Foods Processed at Home: A Pilot Methodology to Inform Consumer-Facing Guidance
Previous Article in Special Issue
Association between Biomarkers of Cardiovascular Diseases and the Blood Concentration of Carotenoids among the General Population without Apparent Illness
 
Search for Articles:
Title / Keyword
Author / Affiliation
Journal
Article Type
 
 
Advanced Search
 
Section
Special Issue
Volume
Issue
Number
Page
Journals
Nutrients
Volume 12
Issue 8
10.3390/nu12082374
nutrients-logo
Submit to this Journal Review for this Journal Edit a Special Issue
► Article Menu

Article Menu

share announcement thumb_up
...
textsms
...
Open AccessArticle

Gamma-Polyglutamic Acid-Rich Natto Suppresses Postprandial Blood Glucose Response in the Early Phase after Meals: A Randomized Crossover Study

by
Risa Araki
1,2,3,4,
Takeshi Yamada
5,
Kazushi Maruo
6,
Akihiro Araki
7,
Rena Miyakawa
1,8,
Hiroaki Suzuki
9 and
Koichi Hashimoto
1,*
1
Department of Clinical and Translational Research Methodology, Faculty of Medicine, University of Tsukuba, 1-1-1 Tennodai, Ibaraki, Tsukuba 305-8575, Japan
2
Food Research Institute of National Agriculture and Food Research Organization, 2-1-12 Kannondai, Ibaraki, Tsukuba 305-8642, Japan
3
R&D Center for Tailor-Made QOL, University of Tsukuba, 1-2 Kasuga, Ibaraki, Tsukuba 305-8550, Japan
4
AIST-University of Tsukuba Open Innovation Laboratory for Food and Medicinal Resource Engineering (FoodMed-OIL) 1-1-1 Higashi, Ibaraki, Tsukuba 305-8565, Japan
5
Department of Gastroenterology, Faculty of Medicine, University of Tsukuba, 1-1-1 Tennodai, Ibaraki, Tsukuba 305-8575, Japan
6
Department of Biostatistics, Faculty of Medicine, University of Tsukuba, 1-1-1 Tennodai, Ibaraki, Tsukuba 305-8575, Japan
7
Faculty of Health Science, Tsukuba International University, 6-8-33 Manabe, Ibaraki, Tsuchiura 300-0051, Japan
8
Graduate School of Comprehensive Human Sciences, University of Tsukuba, 1-1-1 Tennodai, Ibaraki, Tsukuba 305-8575, Japan
9
Department of Internal Medicine (Endocrinology and Metabolism), Faculty of Medicine, University of Tsukuba, 1-1-1 Tennodai, Ibaraki, Tsukuba 305-8575, Japan
*
Author to whom correspondence should be addressed.
Nutrients 2020, 12(8), 2374; https://doi.org/10.3390/nu12082374
Received: 30 May 2020 / Revised: 3 August 2020 / Accepted: 6 August 2020 / Published: 8 August 2020
(This article belongs to the Special Issue The Effects of Phytochemicals on Health Benefit)
View Full-Text Download PDF
Browse Figures

Abstract

We evaluated the suppressive effects of high-gamma-polyglutamic acid (γ-PGA) natto on postprandial blood glucose level and insulin response. After confirming the eligibility of candidates using a pre-selective test with packaged white rice, a meal loading test including low- or high-γ-PGA natto (with 57.6 mg (LPGA) and 439.6 mg (HPGA) of γ-PGA, respectively) was conducted in men aged 20 to 70 years (n = 29) and postmenopausal women aged ≤70 years (n = 7). On each examination day, blood samples were obtained after they fasted overnight and for 120 min after test meal loading. The primary outcome of this study was the difference between the measurements of the incremental area under the curve (IAUC) for blood glucose 0 to 30 min after loading of LPGA and HPGA meals. The IAUCs for blood glucose and insulin after the HPGA meal were lower than those after the LPGA meal within 45 min (0 to 15 and 0 to 30 min: p < 0.001, 0 to 45 min: p < 0.01) and 1 h (all p < 0.001) of loading, respectively. The suppressive effects of HPGA natto on postprandial glucose response in the early phase, which possibly relates to the risk of dysglycemia and cardiovascular disease, were clarified. View Full-Text
Keywords: gamma-polyglutamic acid; natto; postprandial glucose; meal loading test; human health gamma-polyglutamic acid; natto; postprandial glucose; meal loading test; human health
►▼ Show Figures

Figure 1

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited
SciFeed

Share and Cite

MDPI and ACS Style

Araki, R.; Yamada, T.; Maruo, K.; Araki, A.; Miyakawa, R.; Suzuki, H.; Hashimoto, K. Gamma-Polyglutamic Acid-Rich Natto Suppresses Postprandial Blood Glucose Response in the Early Phase after Meals: A Randomized Crossover Study. Nutrients 2020, 12, 2374. https://doi.org/10.3390/nu12082374

AMA Style

Araki R, Yamada T, Maruo K, Araki A, Miyakawa R, Suzuki H, Hashimoto K. Gamma-Polyglutamic Acid-Rich Natto Suppresses Postprandial Blood Glucose Response in the Early Phase after Meals: A Randomized Crossover Study. Nutrients. 2020; 12(8):2374. https://doi.org/10.3390/nu12082374

Chicago/Turabian Style

Araki, Risa; Yamada, Takeshi; Maruo, Kazushi; Araki, Akihiro; Miyakawa, Rena; Suzuki, Hiroaki; Hashimoto, Koichi. 2020. "Gamma-Polyglutamic Acid-Rich Natto Suppresses Postprandial Blood Glucose Response in the Early Phase after Meals: A Randomized Crossover Study" Nutrients 12, no. 8: 2374. https://doi.org/10.3390/nu12082374

Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Metrics

Article Access Map by Country/Region

1
Search more from Scilit
 
Search
Back to TopTop