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Review

Vitamin C for Cardiac Protection during Percutaneous Coronary Intervention: A Systematic Review of Randomized Controlled Trials

1
Department of Pharmacy Practice and Science, College of Pharmacy, University of Arizona, 1295 N. Martin Ave, Tucson, AZ 85721, USA
2
Department of Cardiac Surgery, Vanderbilt University, Nashville, TN 37203, USA
3
Annette and Irwin Eskind Family Biomedical Library, Jean & Alexander Heard Libraries, Vanderbilt University, Nashville, TN 37203, USA
*
Author to whom correspondence should be addressed.
Nutrients 2020, 12(8), 2199; https://doi.org/10.3390/nu12082199
Received: 27 June 2020 / Revised: 17 July 2020 / Accepted: 21 July 2020 / Published: 23 July 2020
(This article belongs to the Special Issue Vitamin C: From Bench to Bedside)
Percutaneous coronary intervention (PCI) is the preferred treatment for acute coronary syndrome (ACS) secondary to atherosclerotic coronary artery disease. This nonsurgical procedure is also used for selective patients with stable angina. Although the procedure is essential for restoring blood flow, reperfusion can increase oxidative stress as a side effect. We address whether intravenous infusion of vitamin C (VC) prior to PCI provides a benefit for cardioprotection. A total of eight randomized controlled trials (RCT) reported in the literature were selected from 371 publications through systematic literature searches in six electronic databases. The data of VC effect on cardiac injury biomarkers and cardiac function were extracted from these trials adding up to a total of 1185 patients. VC administration reduced cardiac injury as measured by troponin and CK-MB elevations, along with increased antioxidant reservoir, reduced reactive oxygen species (ROS) and decreased inflammatory markers. Improvement of the left ventricular ejection fraction (LVEF) and telediastolic left ventricular volume (TLVV) showed a trend but inconclusive association with VC. Intravenous infusion of VC before PCI may serve as an effective method for cardioprotection against reperfusion injury. View Full-Text
Keywords: Vitamin C (VC); periprocedural myocardial injury (PMI); troponin; CK-MB; left ventricular ejection fraction (LVEF); reactive oxygen species (ROS) Vitamin C (VC); periprocedural myocardial injury (PMI); troponin; CK-MB; left ventricular ejection fraction (LVEF); reactive oxygen species (ROS)
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MDPI and ACS Style

Khan, S.A.; Bhattacharjee, S.; Ghani, M.O.A.; Walden, R.; Chen, Q.M. Vitamin C for Cardiac Protection during Percutaneous Coronary Intervention: A Systematic Review of Randomized Controlled Trials. Nutrients 2020, 12, 2199. https://doi.org/10.3390/nu12082199

AMA Style

Khan SA, Bhattacharjee S, Ghani MOA, Walden R, Chen QM. Vitamin C for Cardiac Protection during Percutaneous Coronary Intervention: A Systematic Review of Randomized Controlled Trials. Nutrients. 2020; 12(8):2199. https://doi.org/10.3390/nu12082199

Chicago/Turabian Style

Khan, Sher Ali, Sandipan Bhattacharjee, Muhammad Owais Abdul Ghani, Rachel Walden, and Qin M. Chen. 2020. "Vitamin C for Cardiac Protection during Percutaneous Coronary Intervention: A Systematic Review of Randomized Controlled Trials" Nutrients 12, no. 8: 2199. https://doi.org/10.3390/nu12082199

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